We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation retention ability to clear out body in living subjects. The combination spin-canting effects collection gadolinium species within GdIO nanoparticles led significantly effect. For example, with diameter ∼4.8 nm exhibited high r1 relaxivity 7.85 mM–1·S–1 low r2/r1 ratio 5.24. After being...

We report the synthesis of a novel 2D hybrid nanosheet constructed by few layered MoSe₂ grown on reduced graphene oxide (rGO), which exhibits excellent electrochemical performance as anodes for lithium ion batteries.

Chronic wounds have imposed a severe physical and economic burden on the global healthcare system, which are usually treated by delivery of drugs or bioactive molecules to wound bed through dressings. In this work, we demonstrated hydrogel-functionalized bandage with Janus wettability in bilayer structure achieve unidirectional drug multifunctional care. The patterned porous gradient wetting channels upper layer is responsible for transport from outside (up 90% efficiency) while preventing...

Diabetic wound healing remains as a serious challenge for medical circles that required continuous monitoring and effective management. Herein, the glucose oxidase/carbon dots@copper-metal–organic framework-based nanofibers (GOx/CDs@MOF NFs) were proposed multifunctional dressing, aiming to visually monitor pH inhibit bacterial infection. In diabetic microenvironment, GOx/CDs@MOF NFs could convert endogenous into hydroxyl radial (•OH) through cascade catalytic reaction. vivo vitro...

Magnetic resonance angiography using gadolinium-based molecular contrast agents suffers from short diagnostic window, relatively low resolution and risk of toxicity. Taking into account the chemical exchange between metal centers surrounding protons, magnetic nanoparticles with suitable surface interfacial features may serve as alternative T1 agents. Herein, we report engineering on structure iron oxide nanoplates to boost ability through synergistic effects exposed metal-rich Fe3O4(100)...

Increasing demand for the knowledge about protein-protein interactions (PPIs) is promoting development of methods predicting protein interaction network. Although high-throughput technologies have generated considerable PPIs data various organisms, it has inevitable drawbacks such as high cost, time consumption, and inherently false positive rate. For this reason, computational are drawing more attention PPIs. In study, we report a method using information sequences. The main improvements...

A flexible, self-healable, adhesive and wearable hydrogel patch for sweat colorimetric analysis can achieve personalized in situ point-of-care detection.

In the field of wearable sensing, small and precise sensors can greatly reduce burden on wearer improve sense experience, which is future direction sensing development. Herein, we introduce an ultra-small biosensor system that integrates MS02 chip for real-time highly accurate sweat detection. The whole mainly includes flexible electrodes a printed circle board (PCB). size PCB only 1.5 cm × 0.8 cm, minimizes improves wearing comfort. Notably, this miniaturized comparable to commercial...

The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects NAC are still major challenge. To solve this problem, we developed photoenhanced (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate), which is abbreviated...

Alkaline water electrolysis is considered a commercially viable option for large-scale hydrogen production. However, this process still faces challenges due to the high voltage (>1.65 V at 10 mA cm$^{-2}$) and its limited stability higher current densities inefficient electron transport kinetics. Herein, novel cobalt based metallic heterostructure (Co$_3$Mo3N/Co$_4$N/Co/Co) designed application electrolysis. Operando Raman experiments reveal that formation of Co$_3$Mo3N/Co$_4$N/Co...

Reliably monitoring sweat volume has attracted much attention due to its important role in the assessment of physiological health conditions and prevention dehydration. Here, we present first example wearable strain sensor for real-time monitoring. Such is simply fabricated via embedding sensing fabric super-absorbent hydrogels, hydrogels can wick up off skin surface swell then trigger fabrics response. This realize detection (0.15–700 μL), shows excellent repeatability stability against...

Active enrichment can detect nucleic acid at ultra-low concentrations without relatively time-consuming polymerase chain reaction (PCR), which is an important development direction for future rapid detection. Here, we reported integrated active platform direct hand-held detection of COVID-19 in nanoliter samples PCR. The consists a capillary-assisted liquid-carrying system sampling, circuit ultrasound output, and cell-phone-based surface-enhanced Raman scattering (SERS) system. Considering...

A multiple gadolinium complex decorated fullerene (CGD_n) as an enhanced <italic>T</italic>₁ contrast agent was presented.

High-performance magnetic resonance imaging (MRI) contrast agents and novel enhancement strategies are urgently needed for sensitive accurate diagnosis. Here we report a strategy to construct new T1 agent based on the Solomon–Bloembergen–Morgan (SBM) theory. We loaded ultrasmall gadolinium oxide nanoparticles into worm-like interior channels of mesoporous silica nanospheres (Gd2O3@MSN nanocomposites). This unique structure endows nanocomposites with geometrical confinement, high molecular...

A novel portable energy harvester using 3-3 mode piezoelectric stack with two-stage force amplification is proposed. It can obtain 21 times 18% transmission ratio and generate electrical up to 79 more than one ceramic of lead zirconate titanate (PZT) stack. Dynamic experiments demonstrate that the one-and maximum power 74.9 mW/g 2 from PZT at resonance frequency 235 Hz matching resistance 268 Ohms 2642 three stacks 37 match 1722 Ohm under 100 g proof mass 0.1 acceleration. Theoretical...

Magnetic resonance contrast agents with T1–T2 dual mode capability have attracted considerable interest because they offer complementary and synergistic diagnostic information, leading to high imaging sensitivity accurate diagnosis. Here, we reported a facile strategy construct albumin based nanoparticles loaded hydrophobic gadolinium chelates by interaction for magnetic (MRI). We synthesized glycyrrhetinic acid-containing Gd-DOTA derivative (GGD) GGD molecules into BSA form GGD–BSA (GGD–BSA...

The need for better imaging assisted cancer therapy calls new biocompatible agents with excellent and therapeutic capabilities. This study successfully fabricates albumin-cooperated human serum albumin (HSA)-GGD-ICG nanoparticles (NPs), which are comprised of a magnetic resonance (MR) contrast agent, glycyrrhetinic-acid-modified gadolinium (III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (GGD), fluorescence (FL) dye, indocyanine green (ICG), multimodal MR/FL therapy. These...

Dual-modal fluorescence and magnetic resonance imaging (FLI/MRI) is important for the early diagnosis of malignant tumors. However, facile opportune strategies to synergistically enhance intensity (MR) contrast have rarely been reported. Herein, we present a strategy using albumin aggregates (AAs) by aggregation-induced emission (AIE) MR with prolonged rotational correlation time (τR) Gd(III) chelates diffusion (τD) surrounding water molecules. The amphiphilic dual-modal FLI/MRI probe NGd...