Abstract Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring. Here, we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable portable recognition fingerprint information targeted biomarkers including urea, lactate, pH in sweat. A miniature, thin plasmonic metasurface homogeneous mushroom-shaped hot spots high surface-enhanced Raman scattering (SERS) activity is designed integrated into...

Monitoring the acetaminophen dosage is important to prevent occurrence of adverse reactions such as liver failure and kidney damage. Traditional approaches monitoring mainly rely on invasive blood collection. Herein, we developed a noninvasive microfluidic-based wearable plasmonic sensor achieve simultaneous sweat sampling drug for vital signs. The fabricated employs an Au nanosphere cone array key sensing component, which poses substrate with surface-enhanced Raman scattering (SERS)...

Chronic wounds have imposed a severe physical and economic burden on the global healthcare system, which are usually treated by delivery of drugs or bioactive molecules to wound bed through dressings. In this work, we demonstrated hydrogel-functionalized bandage with Janus wettability in bilayer structure achieve unidirectional drug multifunctional care. The patterned porous gradient wetting channels upper layer is responsible for transport from outside (up 90% efficiency) while preventing...

Abstract Wearable optical sensors have emerged as a promising technology, opening up new way to monitor human sweat. With the advancement of integrated devices, materials, and structure design, current skin interfaces primarily employ four analytical methods transmit sweat chemical information into signals: colorimetry, surface-enhanced Raman spectroscopy, fluorescence, electrochemiluminescence. To improve portability, many external laser source devices imaging modules are upgraded based on...

Enrichment and enhancement are two important aspects of ultratrace biomolecule recognition in complex biological samples. Here we integrate acoustic aggregation modified Au nanorods with Raman for all-in-one rapid detection one microliter solution. Arising from the interaction between individual nanoparticles field, results migration specifically toward pressure node a few seconds accompanies enrichment specific biomolecular. As proof concept, sensitive surface-enhanced scattering (SERS)...

Active enrichment can detect nucleic acid at ultra-low concentrations without relatively time-consuming polymerase chain reaction (PCR), which is an important development direction for future rapid detection. Here, we reported integrated active platform direct hand-held detection of COVID-19 in nanoliter samples PCR. The consists a capillary-assisted liquid-carrying system sampling, circuit ultrasound output, and cell-phone-based surface-enhanced Raman scattering (SERS) system. Considering...

Abstract “Green Synthesis” has been broadly applied in drug synthesis and nanomaterial preparation. The integration of automated micro‐synthesis high‐throughput screening systems is a key way to achieve the goal green manufacturing. Here, one‐click platform designed that integrates droplets arrays‐based for Raman enhancement performance MNPs@Cu‐MOF (AuNPs@, AgNPs@, PtNPs@Cu‐MOF) under room temperature normal pressure. fully integrated ultrasound units can rapid multi‐component mixing droplet...

Metal–organic frameworks (MOFs) have recently been widely used in antimicrobial fields due to their adjustable composition and morphology. The inherent properties of MOFs (e.g., shape, size, metal element) are highly related antibacterial performance. traditional beaker-based synthesis system evaluate often leads high reagent costs environmental pollution. Here, a low-cost droplet-based microscale platform for better economical screening performance is demonstrated. Multiple (Zn-, Co-,...

The point-of-care (POC) testing of cancer biomarkers in saliva with both high sensitivity and accuracy remains a serious challenge modern clinical medicine. Herein, we develop new fully integrated ratiometric fluorescence enrichment platform that utilizes acoustic radiation forces to enrich dual-emission sandwich immune complexes for POC visual assay. As result, the color signals from red green (capture probe report probe, respectively) are enhanced by nearly 10 times, colorimetric is...

Artificial olfactory systems have been widely used in medical fields such as the analysis of volatile organic compounds (VOCs) human exhaled breath. However, there is still an urgent demand for a portable, accurate breath VOC system healthcare industry. In this work, we proposed Janus colorimetric face mask (JCFM) comfortable evaluation ammonia levels by combining machine learning K-nearest neighbor (K-NN) algorithm. Such fabric designed unidirectional penetration moisture, which can reduce...

Abstract The colloidal gold nanoparticle (AuNP)‐based colorimetric lateral flow assay (LFA) is one of the most promising analytical tools for point‐of‐care disease diagnosis. However, low sensitivity and insufficient accuracy still limit its clinical application. In this work, a machine learning (ML)‐optimized LFA with ultrasound enrichment developed to achieve sensitive accurate detection tau proteins early screening Alzheimer's (AD). device integrated portable ultrasonic actuator rapidly...

The separation of xylene isomers is a critical and energy‐intensive process in the petrochemical industry, primarily due to their closely similar molecular structures boiling points. In this work, we report synthesis application novel core‐shell zeolitic imidazolate framework (ZIF) composite, ZIF‐65@ZIF‐67, designed significantly enhance kinetic through synergistic "shell‐gated diffusion core‐facilitated transport" strategy. external ZIF‐67 shell selectively restricts larger (MX OX), while...

The separation of xylene isomers is a critical and energy‐intensive process in the petrochemical industry, primarily due to their closely similar molecular structures boiling points. In this work, we report synthesis application novel core‐shell zeolitic imidazolate framework (ZIF) composite, ZIF‐65@ZIF‐67, designed significantly enhance kinetic through synergistic "shell‐gated diffusion core‐facilitated transport" strategy. external ZIF‐67 shell selectively restricts larger (MX OX), while...

Single-functional wound dressings provide limited therapeutic benefits for chronic healing. Effective care wounds requires a multifunction that integrates exudate management, treatment, and continuous monitoring. Here, we introduce an integrated Janus bioelectronic bandage designed to achieve self-pumping management via electrospinning dressing with opposite wettability, antibacterial properties through silver nanoparticles (AgNPs), the monitoring of multiplex biomarkers in electrochemical...

Lateral flow biosensor (LFB) is one of the most successful and applied commercial detection methods for food safety, drug abuse, disease. Here, we integrated ultrasound enrichment as sample preparation with LFB to achieve ultra-trace protein in blood. When field applied, interaction between acoustic gold nanoparticles can gather specifically modified toward pressure nodes seconds enrich target proteins. Such an approach detect a linear range 1–20 ng mL–1 limit 0.58 blood within 20 min, which...

The current polymerase chain reactions-based nucleic acid tests for large-scale infectious disease diagnosis are always lab-dependent and generate large amounts of highly plastic waste. Direct non-linear acoustic driven microdroplets provide an ideal platform contactless spatial temporal manipulation liquid samples. Here, a strategy to programmable-manipulate using potential pressure well trace detection is conceptualized designed. On such modulation platform, up seventy-two piezoelectric...