A5069483614- Nanoplatforms for cancer theranostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Luminescence and Fluorescent Materials
- Cancer-related molecular mechanisms research
- Obstructive Sleep Apnea Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Click Chemistry and Applications
- Respiratory Support and Mechanisms
- Single-cell and spatial transcriptomics
- Organic Light-Emitting Diodes Research
- Advanced biosensing and bioanalysis techniques
- Adenosine and Purinergic Signaling
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Vehicle emissions and performance
- Salivary Gland Disorders and Functions
- Colorectal Cancer Treatments and Studies
- Congenital heart defects research
- Intraocular Surgery and Lenses
- Urban Transport and Accessibility
- Molecular Sensors and Ion Detection
- Spectroscopy and Laser Applications
- Cardiac Fibrosis and Remodeling
Tongji University
2010-2024
Tongji Hospital
2010-2024
Chongqing University of Education
2023-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Soochow University
2020-2023
First Affiliated Hospital of Wannan Medical College
2018-2023
First Affiliated Hospital of Soochow University
2020-2023
Chongqing Technology and Business University
2023
Wenzhou Medical University
2020-2022
The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects NAC are still major challenge. To solve this problem, we developed photoenhanced (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate), which is abbreviated...
The development of functional materials for tumor immunogenicity enhancement is desirable overcoming the low therapeutic efficiency and easy metastasis during treatments. Herein, thermoresponsive nanoparticles composed photothermal agent (PTA) click reactive reagent are developed enhanced immunotherapy application. A Ni-bis(dithiolene)-containing PTA with intense near-infrared absorption efficient conversion construction. generated heat by encapsulated further induces phase transition...
The concept of aggregate science was proposed to explain changes in materials performance that accompany the generation aggregates, but aggregation-triggered multifunction improvements a class have rarely been reported. Herein, we present first report new multifunctional aggregation-induced emission (AIE) luminogens (AIEgens) based on 5,10-diarylphenazine (DPZ) derivates with full-wavelength emission. Intriguingly, multiple properties, such as fluorescence intensity and free radical type I...
Tanshinone IIA (Tan IIA), a compound extracted from Salvia miltiorrhiza, can improve type II diabetes, while the molecular mechanisms underlying Tan IIA-mediated protective effects in diabetic nephropathy are unclear. This study explored actions of on renal tissues streptozotocin (STZ)-induced nephropathy.Tan (2, 4, 8 mg/kg/day) was daily administered to STZ-treated rats by intraperitoneal injection for 42 days. The morphologic pathology evaluated hematoxylin-eosin and Masson's trichrome...
Numerous studies proved that long non-coding RNA (lncRNA) is involved in the progression of multifarious diseases, especially some carcinomas. As a potential tumor biomarker, plasmacytoma variant translocation 1 gene (PVT1) development and cancers. Nevertheless, intrinsic concrete molecular mechanism PVT1 bladder cancer still remained unclear, which also dilemma faced many studies.Our research revealed was significantly higher expression carcinoma specimens cell lines. Further experiments...
Acute myocardial infarction (AMI) can occur in patients with atherosclerotic disease, or without plaque rupture. Previous studies have indicated a set of immune responses to However, the specific circulating cell subsets that mediate inflammatory rupture remain elusive.
Large intracoronary thrombus burden is not rare during primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). Stress hyperglycemia independently associated poor prognosis. However, the underlying relationship between stress and remains unknown. This study aims to investigate association of hyperglycemia, evaluated by combination chronic glycemic levels, diabetic STEMI.We enrolled 227 consecutive STEMI undergoing PCI within...
Chronic heart failure (CHF) is a prevalent health concern with complex pathogenesis. This current study set out to estimate the function of miR-129-5p/Smurf1/PTEN axis on cardiac injury in CHF. The model CHF rats was established. indexes, myocardial tissue damage, and oxidative stress-related factors were evaluated after interference Smurf1/miR-129-5p/PTEN. targeting relationships between miR-129-5p Smurf1 PTEN verified. It found that modeling, functions impaired, heart/left ventricular/lung...
Abstract Ferroptosis is associated with the occurrence and development of many diseases, which result an imbalance in cellular metabolism oxidation−reduction balance. Therefore, it effective therapeutic strategy that simultaneously regulating intracellular system. Herein, a click reaction alkynylamide thiol groups presence amine or PBS (pH = 7.4) developed, can react efficiently substances, such as cysteine (Cys), glutathione (GSH), bovine serum albumin (BSA). Notably, MBTB‐PA,...
We aimed to investigate the association between red cell index (RCI) and severity of Chronic Obstructive Pulmonary Disease (COPD), compare predictive value RCI, neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) for COPD.A total 207 participants were recruited (100 COPD patients 107 healthy controls). divided into two groups according optimal cut-off RCI determined by receiver operating characteristic (ROC) curve. Pearson's correlation test, logistic regression analysis other tests...
In order to scientifically evaluate the characteristics and impact outcomes of transportation carbon emissions, this paper uses panel statistics 286 cities measure emissions analyze their spatial correlation characteristics. Afterwards, primarily based on current research, a system indicators for factors was established. After that, ordinary least squares regression, geographically weighted multiscale regression models were used data, model selected heterogeneity elements influencing...
This work demonstrated that the aggregation and de-aggregation strategy of AIEgens in nanomicelles is very attractive for constructing multifunctional theranostic probes.
Purpose: This study aimed to explore the relation between lymphocyte high-density lipoprotein ratio (LHR) and pulmonary function of chronic obstructive disease (COPD) patients compared with neutrophil–lymphocyte (NLR) platelet–lymphocyte (PLR). Patients Methods: In total, 154 participants (n = 77 COPD n without COPD) were recruited. LHR, NLR, PLR, lung other data collected compared. Pearson's correlation test receiver operating characteristics curves used compare utility NLR PLR. Besides,...
7510 Background: The JBR.10 trial demonstrated a significant survival benefit from adjuvant chemotherapy in stage IB-II NSCLC patients (HR 0.69, p=0.04). However, interaction with was seen, limited to II patients. Gene expression profiling may identify patient groups significantly different prognosis, potential for improved selection of receive chemotherapy. Methods: by Affymetrix U133A performed on RNA isolated snap-frozen banked tumor tissues 133 (62 observation and 71 chemotherapy) A...
Atrial fibrillation (AF) is one of the most prevalent heart rhythm disorder. The causes AF include age, male sex, diabetes, hypertension, valve disease, and systolic/diastolic dysfunction. But on molecular level, its mechanisms are largely unknown. In this study, we collected 10 patients with persistent atrial fibrillation, paroxymal healthy individuals did MethylationEPIC BeadChip RNA sequencing. By analyzing methylation gene expression data using machine learning based feature selection...
We aimed to investigate the role of platelet-to-lymphocyte ratio (PLR) in cognitive decline patients with type 2 diabetes mellitus (T2DM).A total number 261 T2DM were enrolled this study. The divided into two groups according median PLR (PLR < 96.5, n = 130; ≥ 131). Cognitive impairment was defined as Mini-mental State Examination score ≤ 26. Student's t test and Chi-square used difference between groups, logistics regression analysis performed verify whether high an independent factor for...
A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro vivo tumor ablation were significantly acquired at low-temperature.
The divergence and continuous evolution of plants animals contribute to ecological diversity. Promoters transcription factors (TFs) are key determinants gene regulation throughout life. However, the evolutionary trajectories relationships promoters TFs still poorly understood. Here, we conducted extensive analysis large-scale multi-omics sequences in 420 animal species 223 plant spanning nearly a billion years history. Results showed that promoter GC-content TF isoelectric points, as...
Chronic Obstructive Pulmonary Disease (COPD) has been a concern all over the world because of its high prevalence and mortality. The ratio low-density-lipoprotein to lymphocyte (LLR) widely used predict prognosis cerebral infarction, but association with COPD is less known. We aim explore relationship between LLR investigate indicative role in severity COPD.In this study, 279 participants (n = 138 n age- sex-matched health control) were recruited. patients divided into two groups according...