A5101707275- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Sarcoma Diagnosis and Treatment
- Peripheral Nerve Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Sleep and related disorders
- Herpesvirus Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Fractal and DNA sequence analysis
- Connexins and lens biology
- Tunneling and Rock Mechanics
- Cardiovascular Disease and Adiposity
- Natural Products and Biological Research
- Parvovirus B19 Infection Studies
Wenzhou Medical University
2011-2025
Ruian People's Hospital
2021-2025
Subang Jaya Medical Centre
2009-2024
Sichuan Normal University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shaanxi University of Chinese Medicine
2023
Lishui City People's Hospital
2023
First Affiliated Hospital of Gannan Medical University
2023
University of Nebraska Medical Center
2019
Racial and ethnic disparities persist in the incidence treatment outcomes of childhood acute lymphoblastic leukemia (ALL). However, there is a paucity data describing genetic basis these disparities, especially association with modern ALL molecular taxonomy context contemporary regimens.To evaluate ancestry subtypes therapy.This multinational, multicenter study was conducted from March 1, 2000, to November 20, 2020, among 2428 children adolescents enrolled frontline trials United States,...
Preoperative ultrasound examination of thyroid nodules is the most economical and effective screening method for diagnosing nodules. Fine-needle aspiration biopsy (FNAB) cytology guided by has high sensitivity specificity in distinguishing benign malignant However, approximately 25% cannot be determined FNAB, accurate differentiation critical patient prognosis. Here, we report diagnosis surgical treatment process a rare with bilateral tumor independent origin. This had significantly elevated...
ABSTRACT A conventional target detection technique for FMCW millimeter‐wave radar applies a two‐dimensional (2D) cell‐averaging constant false alarm rate (CA‐CFAR) detector to all range‐doppler cells in order suppress noise and clutter. However, this 2D CA‐CFAR method has significant drawbacks, particularly its high computational cost due the large number of additions required, resulting time complexity O(n 4 ). To decrease while ensuring accuracy, novelty based on prefix sum algorithm with...
To investigate whether, for children with favorable-risk B-cell precursor ALL (BCP-ALL), an anthracycline-free protocol is noninferior to a modified Berlin-Frankfurt-Muenster ALL-IC2002 protocol, which includes 120 mg/m2 of anthracyclines.Three hundred sixty-nine BCP-ALL (age 1-9 years, no extramedullary disease, and high-risk genetics) who cleared minimal residual disease (≤0.01%) at the end remission induction were enrolled into Ma-Spore (MS) trials. One sixty-seven standard-risk (SR)...
Personalized risk stratification and treatment may help improve outcomes among patients with diffuse large B-cell lymphoma (DLBCL). We developed a next-generation sequencing (NGS)-based method to assess range of potential prognostic indicators, evaluated it using pretreatment plasma samples from 310 previously untreated DLBCL the GOYA trial (NCT01287741). Variant calls subtyping plasma-based were concordant corresponding tissue-based methods. Patients tumor burden greater than median (p =...
Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol its anti-inflammatory effects on microglia found that treatment associated with substantial lower levels extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from reversed propofol-mediated neuroprotective effects, suggesting reduces proinflammatory activation microglia-mediated neurotoxicity through inhibition EV release. These data shed...
Review of the management 6 young girls with vaginal yolk sac tumor over 25 years showed that α-fetoprotein levels normalized in 5/6 within 4 cycles primary cisplatin, bleomycin, etoposide (PEB)/carboplatin, etoposide, bleomycin (JEB)/cisplatin, vinblastine, (PVB) chemotherapy. Radioimaging revealed residual tissue but viable was found only 1 2 biopsied. Resection/biopsy is necessary to avoid giving additional chemotherapy or identify patients who need different treatment. If markers do not...
Host germline variations and their potential prognostic importance is an emerging area of interest in paediatric ALL.We investigated the associations between 20 various clinical end points 463 children with ALL.After adjusting for known factors, variants two genes were found to be independently associated poorer EFS: ABCB1 T/T at either 2677 (rs2032582) or 3435 (rs1045642) position (P=0.003) IL15 67276493G/G (rs17015014; P=0.022). These showed a strong additive effect affecting outcome...
OBJECTIVE: The 14-3-3 family of conserved regulatory proteins comprises the isoforms beta (β), gamma (γ), zeta (ζ), sigma (ε), tau (η), and delta (σ), which are overexpressed associated with a high risk metastasis poor survival in hepatocellular carcinoma (HCC). In present study, we investigated whether serum related to HCC progression patient survival. METHODS: Serum samples from 63 patients who underwent surgical reSection 104 received non-surgical anti-HCC treatments, 50 liver cirrhosis...
We aimed to investigate the role of platelet-to-lymphocyte ratio (PLR) in cognitive decline patients with type 2 diabetes mellitus (T2DM).A total number 261 T2DM were enrolled this study. The divided into two groups according median PLR (PLR < 96.5, n = 130; ≥ 131). Cognitive impairment was defined as Mini-mental State Examination score ≤ 26. Student's t test and Chi-square used difference between groups, logistics regression analysis performed verify whether high an independent factor for...
The 1970s marked the beginning of childhood cancer services in Malaysia and Singapore, two neighbours South-East Asia. Between 1995 2002, utilized a treatment regimen based on Dutch DCOG 7 German BFM protocols for children with acute lymphoblastic leukaemia (ALL), whilst Singapore collaboration Hong Kong employed HK-ALL 1997 protocol, ALL 95. In overall 6-year event-free survival (EFS) stood at 56%, while 5-year EFS was 79%. Formal between began 2003. first collaborative trial seminal...
Aim Inborn errors of immunity (IEI) comprise a heterogeneous group disorders the immune system, most which are curable by haematopoietic stem cell transplantation (HSCT). We present 25‐year audit HSCT for IEI at tertiary‐level academic hospital in Malaysia. Methods Review medical records all cases who underwent between January 1993 and December 2018 our centre. Diagnoses, complications, protocols outcome data were studied. Results There 20 patients (19 boys) with median age diagnosis 11...
Abstract Background: Astragali radix is prone to be contaminated by various mycotoxins, leading unpredictable threats on the quality and safety of health consumers. Therefore, determination multimycotoxins imperative. Objective: To develop an efficient, sensitive, fast, multianalyte method for detecting in radix. Methods: A selective dilute-and-shoot pretreatment procedure based ultra-performance LC–tandem MS (UPLC-MS/MS) was developed sensitive radix, including aflatoxin (AF) B1, B2, G1,...
Abstract The neutrophil to apolipoprotein A1 ratio has emerged as a possible prognostic biomarker in different medical conditions. Nonetheless, the predictive potential of determining 3-month prognosis acute ischaemic stroke patients who undergo intravenous thrombolysis yet be fully acknowledged. In this study, 196 with recombinant tissue plasminogen activator and 133 healthy controls were included. Meanwhile, we incorporated total 386 non-thrombolytic patients. divided into four groups...
Due to simultaneous horizontal and vertical displacement during evacuation, the consequences of stampede congestion accidents can be more severe. Generally, pedestrians trigger a synchronization mechanism at some point evacuation process. This behavior helps prevent improves efficiency. paper designs well-controlled single-file experiment. After experiment, video footage is imported into TRACKER system extract coordinates pedestrian step movements, after which experimental data undergo...
A conventional target detection technique for FMCW millimeter-wave radar applies a two-dimensional (2D) cell-averaging constant false alarm rate (CA-CFAR) detector to all range-Doppler cells in order suppress noise and clutter. However, this 2D CA-CFAR method has significant drawbacks, particularly its high computational cost due the large number of additions required, resulting time complexity O(n^{4}). To decrease while ensuring accuracy, novelty based on prefix sum algorithm with O(n^{2})...
Objectives This study aimed to investigate the effect and mechanism of recombinant human fibroblast growth factor 18 (rhFGF18) on postmenopausal osteoporosis.
Objectives Pancreatic carcinoid tumor (PCT) is described as a malignant form of tumors. However, the epidemiology and prognostic factors for PCT are poorly understood. Materials Methods The data 2447 patients were included in this study from Surveillance, Epidemiology, End Results database randomly divided into training cohort (1959) validation (488). was calculated, independent identified to construct nomogram predicting long-term disease-specific survival (DSS) among patients. incidence...
Background: The issue of psychological crisis among college students is becoming increasingly prominent. "Savoring" can effectively increase the level subjective well-being and an important protective factor against crisis. However, its mechanism action still unclear requires further exploration. Objective: To explore mediating role personal growth initiative in relationship between well-being, to provide reference for improving enhancing well-being. Methods: Savoring Brief Inventory (SBI),...