A5040544736- Hemophilia Treatment and Research
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Blood transfusion and management
- Childhood Cancer Survivors' Quality of Life
- Cancer-related gene regulation
- Neonatal Health and Biochemistry
- Infections and bacterial resistance
- Family and Disability Support Research
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
- Neuroblastoma Research and Treatments
- Blood disorders and treatments
- Autism Spectrum Disorder Research
- Neurological disorders and treatments
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Lymphoma Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
KK Women's and Children's Hospital
2016-2025
Duke-NUS Medical School
2018-2024
National University of Singapore
2018-2024
Tan Kah Kee Foundation
2024
Tan Tock Seng Hospital
2018
National University Health System
2018
Boston Children's Hospital
2015
McGill University Health Centre
2009
University of Wales
1990
Purpose Although IKZF1 deletion ( IKZF1del) confers a higher risk of relapse in childhood B-cell acute lymphoblastic leukemia (B-ALL), it is uncertain whether treatment intensification will reverse this and improve outcomes. The Malaysia-Singapore ALL 2010 study (MS2010) prospectively upgraded the assignment patients with IKZF1del to next highest level added imatinib all BCR- ABL1 fusion. Patients Methods In total, 823 B-ALL treated Malyasia-Singapore 2003 (MS2003; n = 507) MS2010 (n 316)...
Abstract Anticoagulant treatment of pediatric central venous catheter–related thromboembolism (CVC-VTE) has not been specifically evaluated. In EINSTEIN-Jr, 500 children with any VTE received rivaroxaban or standard anticoagulants. A predefined analysis the CVC-VTE cohort was performed. Children (age, birth to 17 years) were administered anticoagulants during 1-month (children <2 3-month (all other children) study period. Predefined outcomes recurrent VTE, change in thrombotic burden...
Introduction: Stenotrophomonas maltophilia is an aerobic gram-negative bacillus that a frequent coloniser of fluids used in the hospital setting. It causes infection immunosuppressed hosts, especially those who are neutropaenic, on chemotherapy and broad spectrum antibiotics. Skin soft tissue manifestations becoming increasingly recognised entity; clinical ranges from mucocutaneous, skin to infections. Materials Methods: We present case 8-year-old girl with acute myeloid leukaemia developed...
<i>Background:</i> High-dose ibuprofen is clinically effective in cystic fibrosis (CF); however, its molecular mechanisms are poorly understood. <i>Objective:</i> To test the hypothesis that relevant concentrations of suppress activation nuclear factor (NF)-ĸB and thus down-regulate stimulated interleukin (IL)-8 production CF respiratory epithelial cells. <i>Methods:</i> The majority experiments were conducted CFTE29o– cells (F508del-mutated transmembrane...
Objectives. Elizabethkingia meningoseptica is a multi-drug-resistant organism that associated with high mortality and morbidity in newborn immunocompromised patients. This study aimed to identify the best antimicrobial therapy for treating this infection. Methods. A retrospective descriptive was conducted from 2010 2017 tertiary paediatric hospital Singapore. Paediatric patients aged 0 18 years old positive culture E. any sterile site were identified laboratory database. The data collected...
Multisystem inflammatory syndrome in children (MIS-C) is a rare with multisystem involvement affecting exposed to COVID-19. This condition rarely reported East Asia and was not detected Singapore until 2021. We present 12 cases of MIS-C diagnosed KK Women's Children's Hospital (KKH) from October 2021 December 2021.We conducted an observational study on fulfilling the Ministry Health criteria for January 2020 KKH. Medical records were reviewed obtain information clinical presentation, disease...
To investigate whether, for children with favorable-risk B-cell precursor ALL (BCP-ALL), an anthracycline-free protocol is noninferior to a modified Berlin-Frankfurt-Muenster ALL-IC2002 protocol, which includes 120 mg/m2 of anthracyclines.Three hundred sixty-nine BCP-ALL (age 1-9 years, no extramedullary disease, and high-risk genetics) who cleared minimal residual disease (≤0.01%) at the end remission induction were enrolled into Ma-Spore (MS) trials. One sixty-seven standard-risk (SR)...
Patients and methods A longitudinal study was carried out in 255 children from 10 centres nine developing countries over 5 years to assess the musculoskeletal outcome of on episodic factor replacement. Outcome documented by assessment annual joint bleeding rate ( AJBR ), WFH clinical Pettersson radiological scores as well FISH score for activities. Of 203 patients whom data available at end years, 164 who had received only treatment are included this report. Results The median age beginning...
Abstract: During extracorporeal membrane oxygenation (ECMO) support, the underlying disease process and contact between blood non-biological surfaces cause alterations in haemostasis. This results activation of coagulation platelet pathways consumption factors which can provoke haemorrhage, thrombosis or both. Currently, despite its limitations, unfractionated heparin (UFH) is anticoagulant choice patients supported on ECMO. However, there increasing experience with use new anticoagulants...
The PLASMIC score is a convenient tool for predicting ADAMTS13 activity of <10%. Lactate dehydrogenase (LDH) widely used as marker haemolysis in thrombotic thrombocytopenic purpura (TTP) monitoring, and could be replacement lysis. We aimed to validate the multi-centre Asia Pacific region, explore whether LDH lysis.Records patients with microangiopathy (TMA) were reviewed. Patients' levels obtained, along clinical/laboratory findings relevant score. Both scores PLASMIC-LDH scores, which...
This study aimed to document the safety and efficacy of a single infusion autologous umbilical cord blood (UCB) in 20 autistic children aged 24-72 months. A pre-post treatment within-subjects open label design was used. At T = 0, 6, 12, 18 months, participants underwent detailed structured evaluations (via caregiver report), Vineland Adaptive Behavior Scale (Vineland-3), Stanford Binet Intelligence (SB-5), Expressive One-Word Picture Vocabulary Test, Brief Observation Social Communication...
Abstract Background Transfusions are a common intervention within pediatrics and require unique considerations to optimize patient care. Poor knowledge of evidence‐based transfusion practice can lead misuse therapy harm. While there have been assessments medicine physicians caring for adult patients, is little data regarding pediatricians. Study Design Methods Using published exam internal as backbone, pediatric experts, using an iterative process, developed pediatric‐specific examination....
Alloimmunization prevalence is conventionally used to identify RBCs alloimmunization risk factors among thalassemia patients, but it may be confounded by differences in transfusion exposure especially between non-transfusion dependent (NTDT) and (TDT) patients. To better patients with high risks, we cumulative incidence of first as a function transfused compare risks TDT NTDT evaluate other factors. We also proposed practical strategies prevent thalassemia.Adult who had received ≥2...
Iron deficiency anaemia (IDA) remains an important public health problem even in developed countries like Singapore. This clinical update covers recent developments the knowledge of iron metabolism, which aids approach towards diagnosis, management and prevention IDA children. Besides IDA, (ID) has several non-haematological consequences including effects on neurocognition immune function as suggested by animal studies. Thus paediatricians other care providers should work elimination