A5051390460- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Biochemical and Molecular Research
- Cancer Genomics and Diagnostics
- Vaccine Coverage and Hesitancy
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Renal and related cancers
National University of Singapore
2017-2023
National University Health System
2018-2023
KK Women's and Children's Hospital
2018
Purpose Although IKZF1 deletion ( IKZF1del) confers a higher risk of relapse in childhood B-cell acute lymphoblastic leukemia (B-ALL), it is uncertain whether treatment intensification will reverse this and improve outcomes. The Malaysia-Singapore ALL 2010 study (MS2010) prospectively upgraded the assignment patients with IKZF1del to next highest level added imatinib all BCR- ABL1 fusion. Patients Methods In total, 823 B-ALL treated Malyasia-Singapore 2003 (MS2003; n = 507) MS2010 (n 316)...
Abstract Among the recently described subtypes in childhood B-lymphoblastic leukemia (B-ALL) were DUX4- and PAX5-altered (PAX5alt). By using whole transcriptome RNA sequencing 377 children with B-ALL from Malaysia-Singapore ALL 2003 (MS2003) 2010 (MS2010) studies, we found that, after hyperdiploid ETV6-RUNX1, third fourth most common DUX4 (n = 51; 14%) PAX5alt 36; 10%). also formed largest genetic subtype among patients poor day-33 minimal residual disease (MRD; n 12 of 44). But despite MRD,...
To investigate whether, for children with favorable-risk B-cell precursor ALL (BCP-ALL), an anthracycline-free protocol is noninferior to a modified Berlin-Frankfurt-Muenster ALL-IC2002 protocol, which includes 120 mg/m2 of anthracyclines.Three hundred sixty-nine BCP-ALL (age 1-9 years, no extramedullary disease, and high-risk genetics) who cleared minimal residual disease (≤0.01%) at the end remission induction were enrolled into Ma-Spore (MS) trials. One sixty-seven standard-risk (SR)...
T-cell lymphomas arise from a single neoplastic clone and exhibit identical patterns of deletions in receptor (TCR) genes. Whole genome sequencing (WGS) data represent treasure trove information for the development novel clinical applications. However, use WGS to identify clonal proliferations has not been systematically studied. In this study, based on data, we identified monoclonal rearrangements (MRs) receptors genes using segmentation algorithm copy number computation. We evaluated...
Transport drivers have high risk of exposure to SARS-CoV-2 during COVID-19 pandemic. Vaccines can reduce disease severity. However, vaccine perception among transport is unknown. To identify the key factors influencing in Singapore, a cross-sectional pilot study was conducted. One hundred four completed survey responses were collected between September 2021 and February 2022. Using multivariable logistic regression, education, general knowledge attitude, practice social distancing,...
Asparaginase is a critical component of therapy for childhood acute lymphoblastic leukemia (ALL), but it commonly associated with allergy, which results in morbidity and poorer outcomes. The underlying basis this allergy undoubtedly immune-mediated, the exact components T-cell immunity have yet to be characterized. We performed longitudinal TCR sequencing 180 bone marrow samples from 67 children B-ALL treated as part Ma-Spore-ALL-2010 trial, we evaluated associations profile asparaginase...