A5059628446- Blood transfusion and management
- Blood groups and transfusion
- COVID-19 Clinical Research Studies
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Long-Term Effects of COVID-19
- Blood disorders and treatments
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Neutropenia and Cancer Infections
- COVID-19 Impact on Reproduction
- Pancreatic and Hepatic Oncology Research
- Organ Donation and Transplantation
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Diabetes and associated disorders
Hospital Israelita Albert Einstein
2013-2024
Universidade Estadual de Campinas (UNICAMP)
2011-2023
Ben Taub Hospital
2023
Maastricht University Medical Centre
2017
Paracelsus Medical University
2017
Octapharma (Switzerland)
2017
Kyorin University
2007
University of Miyazaki
1999
Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) collection began in two Brazilian hospitals for treatment of severe/critical patients.Mild/moderate COVID-19 convalescents were selected as CCP donors after reverse transcription polymerase chain reaction (RT-PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and absence symptoms ≥14 days plus (a) age (18-60 years), body weight greater than 55 kg; (b) immunohematological studies; (c) no...
Abstract Background Blood donors at the extremes of age spectrum (16–19 years vs. ≥75 years) are characterized by increased risks iron deficiency and anemia, often underrepresented in studies evaluating effects donor characteristics on red blood cells (RBC) transfusion effectiveness. The aim this study was to conduct quality assessments RBC concentrates from these unique groups. Study design We 150 leukocyte‐reduced (LR)‐RBCs units 75 teenage donors, who were matched sex, ethnicity with...
Background Transfusion therapy is associated with increased morbidity, mortality and costs. Conventional coagulation tests (CCT) are weak bleeding predictors, poorly reflecting in vivo. Thromboelastometry (ROTEM) provides early identification of disorders can guide transfusion by goals, reducing blood components transfusion. Objective The aim this study to describe profile critically ill patients using ROTEM evaluate the association between CCT thromboelastometry. Methods This a...
Pyruvate kinase deficiency is a hereditary disease that affects the glycolytic pathway of red blood cell, causing nonspherocytic hemolytic anemia. The transmitted as an autosomal recessive trait and shows marked variability in clinical expression. This study reports on molecular characterization ten Brazilian pyruvate kinase-deficient patients genotype-phenotype correlations.
Blood groups and anti-A isohemagglutinin may be involved in susceptibility to SARS-CoV-2 infection.
Abstract Background Transfusions are a common intervention within pediatrics and require unique considerations to optimize patient care. Poor knowledge of evidence‐based transfusion practice can lead misuse therapy harm. While there have been assessments medicine physicians caring for adult patients, is little data regarding pediatricians. Study Design Methods Using published exam internal as backbone, pediatric experts, using an iterative process, developed pediatric‐specific examination....
Transfusion of blood products during orthotopic liver transplantation (OLT) is associated with increased morbidity and mortality. Although risk factors intraoperative transfusion requirements have been widely assessed, published data on the prediction postoperative are sparse.The aim this study was to evaluate for allogeneic in OLT.Clinical characteristics parameters 645 consecutive adult patients undergoing OLT were retrospectively reviewed. Multivariate logistic regression used determine...
Scott syndrome is a rare bleeding disorder due to an impaired exposure of phosphatidilserine on the platelet membrane, compromising procoagulant activity, thrombin generation and, thus, clot formation. We report case 17-year-old female adolescent with episodes unknown cause. She had normal coagulation, but altered aggregation under arteriolar flow, indicating dysfunction. Furthermore, expression Annexin V was markedly reduced and diagnosis established. treated transfusions demonstrated...
Abstract Background Severe blood donor adverse events are rare, but due to their rarity studying them can be difficult. To get an accurate estimate of frequency and rate in the population it may necessary combine donation data across countries. Study Design Methods International collection organizations (BCOs) provided on rare/severe reactions as well denominator information for populations from 2015 2017. Donor were classified using standardized definitions. Results BCOs six countries...
Background There continues to be uncertainty about the optimal approach documenting bleeding data in platelet transfusion trials, with a desire apply common assessment tool across all trials. With this mind, consensus ( BAT ) has been developed by Biomedical Excellence for Safer Transfusion BEST collaborative, based on review of collection forms used published randomized trials and following content validation range healthcare professionals at seven haematology centres through members. This...
Abstract Background Current evidence regarding COVID‐19 convalescent plasma (CCP) transfusion practices is limited and heterogeneous. We aimed to determine the impact of use CCP in patients with previous circulating neutralizing antibodies (nAbs) COVID‐19. Methods Prospective cohort including 102 transfused ABO compatible on days 0–2 after enrollment. Clinical status was assessed using adapted World Health Organization (WHO) ordinal scale 0, 5, 14. The nAbs titration performed cytopathic...
Background Autologous peripheral blood hematopoietic stem cell (PBSC) collection efficiency (CE) is reportedly affected by the patient's properties; however, studies to identify factors correlated with CE have shown inconsistent results. Additionally, variables such as graft granulocyte content and patient age, sex, underlying disease, may be associated hematopietic (HSC) infusion‐related adverse reactions. In this study, we evaluated correlation of preleukapheresis PB count PBSC harvest...
Microvesicles (MV) are intracellular transmitters that participate in both physiological and pathological conditions, such as inflammatory processes. During orthotopic liver transplantation (OLT), the abrupt exacerbation of response contributes to adverse transplant outcomes. Our hypothesis is MVs released due OLT-associated may serve biomarkers OLT short-term prognosis. In this context, aim study was evaluate changes MV marker levels during their association with Blood samples patients...
Abstract Background Whole blood (WB) collections can occur downrange for immediate administration. An important aspect of these is determining when the unit sufficiently full. This project tested a novel method field collection complete. Methods The amount empty space at top WB units, destined to become LTOWB or separated into components, that were collected centers hospitals was measured by holding off ground and placing piece string where donor tubing entered bag. marked it intersected...