A5001304701- Blood transfusion and management
- Blood donation and transfusion practices
- Blood groups and transfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemoglobinopathies and Related Disorders
- Trauma and Emergency Care Studies
- Platelet Disorders and Treatments
- Complement system in diseases
- Blood disorders and treatments
- Organ Donation and Transplantation
- Hematopoietic Stem Cell Transplantation
- Blood Coagulation and Thrombosis Mechanisms
- Renal Diseases and Glomerulopathies
- Peripheral Neuropathies and Disorders
- Hepatitis B Virus Studies
- Erythrocyte Function and Pathophysiology
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Neonatal Health and Biochemistry
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Electronic Health Records Systems
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
Dartmouth–Hitchcock Medical Center
2016-2025
Dartmouth College
2013-2024
American Association of Blood Banks
2022
All India Institute of Medical Sciences
2021
Canadian Bio-Systems (Canada)
2021
World Health Organization Regional Office for South-East Asia
2021
Wuhan Blood Center
2021
Shaanxi Blood Center
2021
Tan Tock Seng Hospital
2021
Canadian Blood Services
2021
ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical (JCA) Special Issue Writing Committee is charged with reviewing, updating and categorizing indications the evidence‐based use therapeutic apheresis (TA) in human disease. Since 2007 JCA (Fourth Edition), committee has incorporated systematic review approaches grading categorization indications. This Eighth Edition continues to maintain this methodology rigor order make recommendations on a wide variety...
The American Society for Apheresis (ASFA) Journal of Clinical (JCA) Special Issue Writing Committee is charged with reviewing, updating, and categorizing indications the evidence-based use therapeutic apheresis (TA) in human disease. In Ninth Edition, JCA has incorporated systematic review approaches grading evidence categorization to make recommendations on a wide variety diseases conditions. This edition largely maintained general layout concept fact sheet introduced Fourth Edition (2007)....
BACKGROUND: Trauma patients are at risk of developing an acute coagulopathy trauma (ACT) related to tissue injury, shock, and hemodilution. ACT is incompletely understood, but similar disseminated intravascular coagulation (DIC) associated with poor outcome. STUDY DESIGN AND METHODS: Thrombin generation assays were used evaluate plasma hemostasis in 42 patients, 25 normal subjects, 45 on warfarin laboratory‐prepared factor reduced plasma. RESULTS: Prolonged prothrombin time (PT), more than...
Use of universally ABO-compatible group AB plasma for trauma resuscitation can be challenging due to supply limitations. Many centers are now using A during the initial traumatically injured patients. This study was undertaken evaluate impact this practice on mortality and hospital length stay (LOS).Seventeen in patients unknown ABO participated study. Eligible were A, B, who received at least 1 unit plasma. Data collected included patient sex, age, mechanism injury, Trauma Injury Severity...
JFW reports serving as a consultant in medico-legal cases related to kernicterus and for Mallinckrodt Pharmaceuticals. The other authors have no conflicts of interest disclose.
Abstract Background Recently revisited products like low‐titer group O whole blood (LTOWB) and novel applications of A as a universal donor plasma are being used for trauma resuscitation. survey American Level 1 centers was performed to elucidate the extent which these currently employed. Methods written that probed into current use in resuscitation with specific emphasis on LTOWB plasma. list adult civilian continental USA obtained from two public surgery focused websites. An email then...
The short dating period of room temperature-stored platelets (PLTs; 5-7 days) limits their availability at far-forward combat facilities and remote civilian sites in the United States. PLT cryopreservation 6% DMSO storage for up to 2 years may improve timely bleeding patients.A dose escalation trial DMSO-cryopreserved PLTs (CPPs) compared standard liquid-stored (LSPs) was performed patients with thrombocytopenia. Within each four cohorts, six received escalating doses CPP (0.5 unit, 1...
Patients with cirrhosis have abnormal coagulation indices such as a high international normalized ratio and low platelet count, but these do not correlate well periprocedural bleeding risk. We sought to develop consensus among the multiple stakeholders in care inform process measures that can help improve quality of management coagulopathy cirrhosis. identified candidate for contexts relating performance paracentesis upper endoscopy. An 11-member panel content expertise was convened. It...
A predictive marker for AIDS dementia complex (ADC) in a cohort of neurologically asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected patients with < 200 CD4 cells/microL was sought. Patients were assessed and neuropsychologically at entry. Blood cerebrospinal fluid (CSF) taken assay beta 2-microglobulin (beta 2M), neopterin T cell subsets from blood. evaluated every 4 months. Of 37 recruited, 35 had sufficient follow-up data. Seventeen progressed to ADC stage > or = 1. In...
The histologic associations and clinical implications of peritubular capillary C4d staining from long-term renal allografts are unknown. We identified 99 transplant patients who underwent an allograft biopsy for dysfunction at least 10 yr after transplantation, 25 whom were C4d-positive 74 C4d-negative. average time the index transplantation was 14 in both groups. Compared with C4d-negative patients, younger (29 +/- 13 versus 38 12 yr; P < 0.05) more likely to have received a living donor...
BACKGROUND Red blood cell (RBC) antigen matching policies to prevent alloimmunization in females of childbearing potential (FCP) vary between centers. To inform transfusion centers responsible for making decisions about FCPs, the causal stimulus antibodies implicated severe hemolytic disease fetus and newborn (HDFN) must be determined. STUDY DESIGN AND METHODS We conducted a multinational retrospective study women with offspring affected by HDFN requiring neonatal exchange and/or...
BACKGROUND Wrong blood in tube (WBIT) errors are a preventable cause of ABO‐mismatched RBC transfusions. Electronic patient identification systems (e.g., scanning patient's wristband barcode before pretransfusion sample collection) thought to reduce WBIT errors, but the effectiveness these is unclear. STUDY DESIGN AND METHODS Part 1: Using retrospective data, we compared rates at hospitals using manual (n = 16 sites; >1.6 million samples) with electronic for some or all collections 4...
The evidence for the lifesaving benefits of prehospital transfusions is increasing. As such, emergency medical services (EMS) might increasingly become interested in providing this important intervention. While a few EMS and air agencies have been exclusively red blood cell (RBC) to their patients many years, transfusing plasma addition RBCs, or simply using low titer group O whole (LTOWB) place two separate components, will be novel experience services. recommendations presented document...
Eric Gehrie: Honorarium from Cerus Corporation; Consultancies Grifols Diagnostics and Instrumentation Laboratories. Editorial Board, Transfusion. Pampee P. Young: Consultancy Fresenius Kabi; Equity ownership in Eluciderm. Sridhar V. Basavaraju: None. Arthur Bracey: Associate Editor, Transfusion; American Red Cross Medical Advisory Committee; Common Spirit Health—Blood Therapeutic Clinical Council. Andrew Cap: Velico Medical; Liz Culler: Nancy Dunbar: Mary Homer: Iris Isufi: Honoraria Gilead...
A 37-year-old G4P2012 woman with known RhD alloimmunization (highest titer of 32) underwent cesarean delivery at 35-week gestation after MCA Doppler (1.59MoM, Figure 1) suggested severe fetal anemia. vigorous female was born APGAR scores 7 and 9 weighed 2080 g. The neonate admitted to the intensive care unit for prematurity, respiratory distress, hyperbilirubinemia (up 16.4 mg/dL), monitoring hemolytic disease fetus newborn (HDFN) due anti-D (ABPOS, hemoglobin 10 g/dL). Treatment HDFN...
Abstract Background Rho(D) immune globulin (RhIg) is used to reduce RhD alloimmunization in pregnancy. This study describes potential causes for after the development and implementation of RhIg. Study Design Methods retrospective descriptive investigated RhD‐negative patients born 1965–2005 with anti‐D newly identified during 2018–2022. Transfusion, pregnancy, intravenous drug abuse, transplantation were considered sources. Results There 1200 (852 females; 348 males) at 30 institutions 5...
Vox SanguinisEarly View INTERNATIONAL FORUM International Forum on the Use of Irradiated Blood in Patients With Haematological Malignancy: Responses Xiao-Yin Zhang, ZhangSearch for more papers by this authorMichael Murphy, Michael MurphySearch authorGraham P. Collins, Graham CollinsSearch authorVernon J. Louw, Vernon LouwSearch authorGamuchirai Y. Tadzimirwa, Gamuchirai TadzimirwaSearch authorSatyam Arora, Satyam Arora orcid.org/0000-0002-9048-5624 Search authorNita Radhakrishnan, Nita...