A5064931667- Effects of Radiation Exposure
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Disaster Response and Management
- Radiation Therapy and Dosimetry
- COVID-19 Clinical Research Studies
- Blood transfusion and management
- Nuclear Issues and Defense
- Chemical Safety and Risk Management
- SARS-CoV-2 and COVID-19 Research
- Blood donation and transfusion practices
- Radiation Dose and Imaging
- Radioactive contamination and transfer
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Risk and Safety Analysis
- Bacterial Identification and Susceptibility Testing
- Neutropenia and Cancer Infections
- Muscle and Compartmental Disorders
- Radiation Effects and Dosimetry
- Burn Injury Management and Outcomes
- Pesticide Exposure and Toxicity
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 detection and testing
Biomedical Advanced Research and Development Authority
2016-2024
Administration for Strategic Preparedness and Response
2023-2024
Office of Readiness and Response
2021
United States Department of Health and Human Services
2019
Lawrence Livermore National Laboratory
2019
Hudson Institute
2016
John Wiley & Sons (United States)
2016
Eric Gehrie: Honorarium from Cerus Corporation; Consultancies Grifols Diagnostics and Instrumentation Laboratories. Editorial Board, Transfusion. Pampee P. Young: Consultancy Fresenius Kabi; Equity ownership in Eluciderm. Sridhar V. Basavaraju: None. Arthur Bracey: Associate Editor, Transfusion; American Red Cross Medical Advisory Committee; Common Spirit Health—Blood Therapeutic Clinical Council. Andrew Cap: Velico Medical; Liz Culler: Nancy Dunbar: Mary Homer: Iris Isufi: Honoraria Gilead...
ABSTRACT A national need is to prepare for and respond accidental or intentional disasters categorized as chemical, biological, radiological, nuclear, explosive (CBRNE). These incidents require specific subject-matter expertise, yet have commonalities. We identify 7 core elements comprising CBRNE science that integration effective preparedness planning public health medical response recovery. are (1) basic clinical sciences, (2) modeling systems management, (3) planning, (4) incident (5)...
The United States Department of Health and Human Services (HHS) is fully committed to the development medical countermeasures address national security threats from chemical, biological, radiological, nuclear agents. Through Public Emergency Medical Countermeasures Enterprise, HHS has launched managed a multi-agency, comprehensive effort develop operationalize countermeasures. Within HHS, includes National Institutes (NIH), (led by Institute Allergy Infectious Diseases), Office Assistant...
With the end of Cold War in 1991, U.S. Government (USG) investments radiation science and medical preparedness were phased out; however, events 11 September, which involved a terroristic attack on American soil, led to re-establishment funding for both development approaches address injuries. Similar activities have also been instituted worldwide, as global threat radiological or nuclear incident continues be concern. Much USG's efforts plan unthinkable centred establishing clear lines...
The ability to measure neutralizing antibodies on large scale can be important for understanding features of the natural history and epidemiology infection, as well an aid in determining efficacy interventions, particularly outbreaks such current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Because assay's rapid scalability high efficiency, serology measurements that quantify presence rather than function serum often serve proxies immune protection. Here, we report...
Recent studies have demonstrated that early transfusion of plasma or RBCs improves survival in patients with severe trauma and hemorrhagic shock. Time to initiate is the critical factor. It essential begin prehospital environment when transport times are longer than approximately 15 20 minutes. Unfortunately, logistic constraints severely limit use blood products setting, especially military, remote civilian, mass disaster circumstances, where need can be most acute. US military requirements...
The current global pandemic has created unprecedented challenges in the blood supply network. Given recent shortages, there must be a civilian plan for massively bleeding patients when are no products on shelf. Recognizing that time to death is less than 2 h, timely resupply from unaffected locations not possible. One solution transfuse emergency untested whole (EUWB), similar extensive military experience fine-tuned over last 19 years. While this concept anathema transfusion practice, it...
The efficacy of COVID-19 convalescent plasma (CCP) as a treatment for hospitalized patients with remains somewhat controversial; however, many studies have not evaluated CCP documented to high neutralizing antibody titer by highly accurate assay. To evaluate the correlation administration determined live viral neutralization assay 7- and 28-day death rates during hospitalization, total 23 118 receiving single unit were stratified into two groups: those (>250 50% inhibitory dilution, ID50; n...
More evidence is needed to support recommendations for medical management of acute radiation syndrome (ARS) and associated infections resulting from a radiological/nuclear event. While current guidelines recommend the administration antibiotics chemotherapy patients with febrile neutropenia, clinical benefit unclear injury patients. A well-characterized nonhuman primate (NHP) model hematopoietic ARS was developed that incorporates supportive care postirradiation. This evaluated efficacy...
Blood products are likely to be critical components of the medical response nuclear detonation, as hematopoietic subsyndrome acute radiation syndrome (H-ARS) includes depletion platelets and red blood cells that can lead lethal hemorrhage anemia. There is, however, only limited clinical information on use treat H-ARS. As currently configured, US supply cannot meet predicted surge in product demand is occur short-term possibly long-term event a large detonation. part Administration for...
Abstract Although chemical and radiological agents cause toxicity through different mechanisms, the multiorgan injuries caused by these threats share similarities that convene on level of basic biological responses. This publication will discuss areas convergence explore “multi-utility” approaches could be leveraged to address common injury mechanisms underlying actions in a threat-agnostic manner. In addition, we provide an overview current state threat research, US Government’s efforts...
An effective response for a mass-casualty incident requires understanding the relevant basic science and physical impact; detailed preparedness among jurisdictions; clear, sequential planning, including formal operational exercises, logistics, interagency, public-private coordination, rapid activation of resilience, continual improvement from lessons learned new knowledge. This ConRad 2021 meeting report describes steps civilian medical public health planning nuclear detonation; utility this...
An Interagency Panel Session organized by the NASA Human Research Program (HRP) Space Radiation Element (SRPE) was held during HRP Investigator's Workshop (IWS) in Galveston, Texas on 26 January 2017 to identify complementary research areas that will advance testing and development of medical countermeasures (MCMs) support radioprotection radiation mitigation ground space. There were several common interest identified among various participating agencies. This report provides a summary...
Intensive blood use is expected to occur at levels, which will overwhelm supplies as they exist with current capabilities and technologies, both in civilian mass casualty events military battlefield trauma. New technologies are needed for trauma care, specifically provide safer, more effective, logistically supportable products treat patients with, or risk of developing, acquired bleeding disorders resulting from trauma, acute radiation exposure, other causes. Three the primary agencies...
Ionizing radiation can cause devastating injuries including hemorrhage, immune suppression, increased susceptibility to infection, and death. Medical countermeasures (MCMs) that address mitigate radiation-induced are the most important tools for countering consequences of exposure. Likewise, in matters public health security, development advancement radiological MCMs fundamental establishing an effective response nuclear threats. United States Government agencies such as Biomedical Advanced...
Abstract Purpose: To summarize presentations and discussions from the 2022 trans-agency workshop titled “Overlapping science in radiation sulfur mustard (SM) exposures of skin lung: Consideration models, mechanisms, organ systems, medical countermeasures.” Methods: Summary on topics includes: (1) an overview chemical countermeasure development programs missions; (2) regulatory industry perspectives for drugs devices; 3) pathophysiology lung following or SM exposure; 4) mechanisms...