A5004248801- Blood donation and transfusion practices
- Blood transfusion and management
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Organ Donation and Transplantation
- Hepatitis C virus research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Platelet Disorders and Treatments
- HIV/AIDS Research and Interventions
- Erythrocyte Function and Pathophysiology
- Palliative Care and End-of-Life Issues
- Iron Metabolism and Disorders
- Mosquito-borne diseases and control
- HIV, Drug Use, Sexual Risk
- Vector-borne infectious diseases
- Blood disorders and treatments
- Prenatal Screening and Diagnostics
- Viral Infections and Vectors
- Malaria Research and Control
- Ethics and Legal Issues in Pediatric Healthcare
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
Center for Biologics Evaluation and Research
2019-2024
United States Food and Drug Administration
2010-2023
Utah Department of Health
2023
Government of the United States of America
2023
Georgetown University Medical Center
2016-2022
Georgetown University
2016-2022
Seattle University
2016-2020
Emerald Coast Science Center
2018
National Institutes of Health
2008-2017
National Institutes of Health Clinical Center
2016-2017
American Red Cross surveillance data on transfusion-related acute lung injury (TRALI) fatalities were analyzed to evaluate the association with components from donors white blood cell (WBC) antibodies and examine potential impact of selective transfusion plasma male donors.Suspected TRALI reports in 2003 through 2005 identified all reviewed classified by three physicians as "probable TRALI" or "unrelated etiology," independent review associated serologic investigation. Hospital...
BACKGROUND: The American Red Cross initiated systemwide bacterial testing of all apheresis platelet (PLT) collections in March 2004, yet continues to receive reports septic reactions after transfusion screened components. STUDY DESIGN AND METHODS: rates confirmed contamination PLT detected by prospective quality control (QC) testing, and surveillance reported screened‐negative PLTs, were analyzed according the technology utilized for collection. RESULTS: Between 1, May 31, 2006, culture was...
Context Donations by minors (16-and 17-year-olds) now account for approximately 8% of the whole blood collected American Red Cross, but young age and first-time donation status are known to be independent risk factors donationrelated complications.Objective To evaluate adverse reactions allogeneic 16and 17-year-olds compared with older donors in Cross centers.Design, Setting, Participants Prospective documentation events among 16-and 17-year-old using standardized collection protocols,...
Abstract Context.—Serious noninfectious complications are far more likely to occur than viral disease transmission from blood component transfusion. Objective.—To compile a comprehensive list of the risks transfusion, examples published risk estimates, and summaries recent information regarding cause, prevention, or management transfusion risks. Data Sources.—Information was obtained peer-reviewed English-language medical journal publications since 1990. Conclusions.—Early complications,...
Plasma components from female donors were responsible for most cases of transfusion-related acute lung injury (TRALI) reported to the American Red Cross (ARC) between 2003 and 2005. Consequently, we began preferentially distributing plasma male transfusion in 2006 evaluated effect on TRALI ensuing 2 years.Suspected ARC Hemovigilance Program calendar years (CY) 2006, 2007, 2008 are described. Any case involving a fatality was also independently reviewed by three physicians classified as...
BACKGROUND: The American Red Cross (ARC) initiated a comprehensive donor hemovigilance program in 2003. We provide an overview of reported complications after whole blood (WB), apheresis platelet (PLT), or automated red cell (R2) donation and analyze factors contributing to the variability complication rates our national program. STUDY DESIGN AND METHODS: Complications recorded at collection site allogeneic WB, PLT, R2 procedures 36 regional centers 2006 were analyzed by univariate...
BACKGROUND The first step in manufacturing chimeric antigen receptor (CAR) T cells is to collect autologous CD3+ lymphocytes by apheresis. Patients, however, often have leukopenia or other disease‐related complications. We evaluated the feasibility of collecting adequate numbers cells, risk factors for inadequate collections, and rate adverse events. STUDY DESIGN AND METHODS Apheresis lymphocyte collections from patients participating three CAR T‐cell clinical trials were reviewed....
Abstract Ethylene glycol poisoning is an important toxicological problem in medical practice because early diagnosis and treatment can prevent considerable morbidity mortality. When ingested the form of antifreeze or other automotive products, ethylene results central nervous system depression, cardiopulmonary compromise, renal insufficiency. Metabolism to organic acids required for metabolic derangement organ damage. Laboratory features include increased anion gap acidosis, osmolal gap,...
Septic transfusion reactions to apheresis platelets (PLTs) continue occur despite preventive measures. This study evaluated the effect of two operational changes designed reduce bacterial risk: 1) introducing inlet-line sample diversion on two-arm procedures and 2) increasing volume cultured from 4 8 mL all donations.Aerobic culture results septic reported between December 1, 2006, July 31, 2008 (Period 2), were compared March 2004, May 2006 1).During Period 2, a total 781,936 PLT...
Background The A merican R ed C ross began preferentially distributing plasma from male donors in 2007 and subsequently observed an 80% decrease reported cases of transfusion‐related acute lung injury ( TRALI ) after transfusion. Plasma distributions now exceed 99% for groups A, B, O, but only approximately 60% group AB. We evaluated the ongoing risk ABO blood involved donors. Study Design Methods rate suspected per distributed components before (2006) (2008‐2011) implementing predominantly...
On March 25 and 26, 2015, the National Heart, Lung, Blood Institute sponsored a meeting on State of Science in Transfusion Medicine Institutes Health (NIH) campus Bethesda, Maryland, which was attended by diverse group 330 registrants. The meeting's goal to identify important research questions that could be answered next 5 10 years would have potential transform clinical practice transfusion medicine. These addressed basic, translational, and/or studies were focused four areas: three...
Babesia microti, the primary cause of human babesiosis in United States, is an intraerythrocytic parasite endemic to Northeast and upper Midwest. Published studies indicate that B. microti increasingly poses a blood safety risk. The American Red Cross Hemovigilance Program herein describes donor recipient characteristics suspected transfusion-transmitted cases reported between 2005 2007.Suspected infections were by transfusion services or discovered through recipient-tracing investigations...
Committed repeat donors are vital to the continued success of blood collections, yet effect age first-time (FT) donation on return behavior is poorly described. Sixteen-year-old increasingly allowed donate and have highest rates adverse events, which negatively impacts behavior.Annual cohorts allogeneic FT from 2005 2006 were selected within American Red Cross system followed for 25 13 months, respectively. Return total yield among different groups compared.A 2.3 million gave 4.2 donations...
BACKGROUND Apheresis technology to collect platelet (PLT) components differs among devices. We evaluated the relationship of plateletpheresis device with bacterial contamination and reported septic transfusion reactions. STUDY DESIGN AND METHODS Plateletpheresis was performed using Amicus (Fenwal, a Fresenius Kabi Company) or Trima (Trima Accel, TerumoBCT) from 2010 2014. All donations used inlet‐line sample diversion were tested by quality control (QC; Day 1) aerobic culture. Rates...
Hemolytic disease of the fetus and newborn (HDFN) results from maternal IgG antibodies that cross placenta to fetal circulation during gestation cause RBC destruction complications before birth (HDF), or anemia hyperbilirubinemia after (HDN), both. In its most severe form,HDF produces hydrops fetalis, which is characterized by total body edema, hepatosplenomegaly, heart failure can lead intrauterine death. Before discovery Rh immunoglobulin (RhIG), HDFN anti-D was a significant perinatal...
Bacterial sepsis following whole blood-derived platelet (WBP) transfusion has remained a substantial patient risk, primarily due to lack of practical and effective means limit or detect bacterial contamination. We describe the risk reported septic reactions WBPs introduction prestorage-pooled platelets (PSPs) collected using initial sample diversion cultured for contamination.Product qualification quality control (QC) testing with Acrodose PL system (Pall Medical) were evaluated in four...
Skin commensal bacteria account for most septic reactions after apheresis platelet (PLT) transfusion. Consequently, we evaluated the effectiveness of two skin disinfection methods in preventing bacterial contamination PLT collections.Three regional blood centers a one-step 2% chlorhexidine/70% isopropyl alcohol (2% CHX/IPA) method (trial group), while 32 (control group) continued to use two-step povidone-iodine (P-I) method. Aerobic quality control culture results and adverse donor events...
Background Platelet septic reactions result from low concentrations of bacteria that escape detection by quality‐control B ac T / ALERT ™ culture testing. We estimate the contamination rate with these at time testing using a mathematical model. Methods Culture results and reported are described for platelets collected between J anuary 2007 D ecember 2011. Initial positive negative confirmatory cultures were reclassified assuming some ‘unconfirmed results’ represent collections contaminated...