A5023737442- Hematopoietic Stem Cell Transplantation
- Transplantation: Methods and Outcomes
- Blood transfusion and management
- Acute Myeloid Leukemia Research
- Organ Transplantation Techniques and Outcomes
- Blood donation and transfusion practices
- Cancer Genomics and Diagnostics
- Polyomavirus and related diseases
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Organ Donation and Transplantation
- Complement system in diseases
- Neonatal Respiratory Health Research
- HIV/AIDS Impact and Responses
- Platelet Disorders and Treatments
- Reproductive Biology and Fertility
- Blood disorders and treatments
- Erythropoietin and Anemia Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Liver Disease Diagnosis and Treatment
Addenbrooke's Hospital
2015-2024
Cambridge University Hospitals NHS Foundation Trust
2014-2024
NHS Blood and Transplant
2014-2024
National Health Service
2016-2023
National Institute for Health Research
2023
NIHR Cambridge Biomedical Research Centre
2023
University of Cambridge
2012-2017
St George's Hospital
2003-2004
St George's, University of London
2003
The guideline group was selected to be representative of UK-based aplastic anaemia (AA) medical experts. Recommendations are based on review the literature using MEDLINE and PUBMED up December 2014 under heading: 'aplastic anemia'. Grading Assessment, Development Evaluation (GRADE) nomenclature used evaluate levels evidence assess strength recommendations. GRADE criteria specified in BCSH guidance pack...
Summary Pancytopenia with hypocellular bone marrow is the hallmark of aplastic anaemia (AA) and diagnosis confirmed after careful evaluation, following exclusion alternate including hypoplastic myelodysplastic syndromes. Emerging use molecular cyto‐genomics helpful in delineating immune mediated AA from inherited failures (IBMF). Camitta criteria used to assess disease severity, which along age availability human leucocyte antigen compatible donor are determinants for therapeutic decisions....
Deceased donor livers are prone to biliary complications, which may necessitate retransplantation, and we, others, have suggested that these complications because of peribiliary vascular fibrin microthrombi. We sought determine the prevalence consequence occult within deceased undergoing normothermic ex situ perfusion (NESLiP) evaluate a role for fibrinolysis.D-dimer concentrations, products degradation, were assayed in perfusate 163 taken after 2 h NESLiP, including 91 transplanted. These...
Vox SanguinisEarly View INTERNATIONAL FORUM International Forum on the Use of Irradiated Blood in Patients With Haematological Malignancy: Responses Xiao-Yin Zhang, ZhangSearch for more papers by this authorMichael Murphy, Michael MurphySearch authorGraham P. Collins, Graham CollinsSearch authorVernon J. Louw, Vernon LouwSearch authorGamuchirai Y. Tadzimirwa, Gamuchirai TadzimirwaSearch authorSatyam Arora, Satyam Arora orcid.org/0000-0002-9048-5624 Search authorNita Radhakrishnan, Nita...
We have observed epithelial loss from the luminal surface of bile ducts, often in conjunction with underlying stromal necrosis, livers donated after circulatory death (DCD) undergoing ex situ normothermic machine perfusion (NMP).1 On occasion, overlying epithelium has been intact but stroma necrotic, suggesting a vascular occlusive process as opposed to an intraluminal cause. With Research Ethics Committee approval (14/EE/0137), we perfused 5 DCD for at least 4 h using metra (OrganOx,...
Summary Descriptions of passenger lymphocyte syndrome (PLS), immune cytopenias and transplant‐associated thrombotic microangiopathy (TA‐TMA) after intestine‐containing transplants remain scarce. We describe our centre’s experience these complications from 2007 to 2019. Ninety‐six patients received 103 transplants. PLS occurred in 9 (9%) (median 12 days post‐transplant); all due ABO antibodies. There were 31 minor mismatch No patient required change immunosuppression. Immune (excluding PLS)...
Summary. Antithymocyte globulin (ATG) is widely used in the treatment of aplastic anaemia (AA) and a response occurs 60–80% patients. However, its exact mechanism action AA has yet to be determined. Previously, we have shown that ATG increases colony growth from purified bone marrow CD34 + cells patients vitro , decreases stem cell apoptosis expression soluble Fas receptor after therapy vivo . The aim this study was further examine association with haemopoietic progenitor cells. We describe...
Descriptions of passenger lymphocyte syndrome (PLS), immune cytopenias and transplant associated thrombotic microangiopathy (TA-TMA) in patients with intestine-containing grafts remains scarce. We describe our experience these complications a retrospective chart review from 2007-2019. 96 received 103 transplants. PLS occurred 9 (9%) (median 12 days post-transplant); all due to ABO antibodies. There were 31 minor mismatch No patient required change immunosuppression. Immune (excluding PLS) 6...