A5020535100- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Trauma and Emergency Care Studies
- Blood donation and transfusion practices
- Blood groups and transfusion
- Cardiac Arrest and Resuscitation
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Abdominal Trauma and Injuries
- Hemoglobin structure and function
- Organ Transplantation Techniques and Outcomes
- Disaster Response and Management
- Xenotransplantation and immune response
- Pregnancy-related medical research
- Iron Metabolism and Disorders
- Hepatitis B Virus Studies
- Neonatal Health and Biochemistry
- Virus-based gene therapy research
- Hemostasis and retained surgical items
- Pelvic and Acetabular Injuries
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Healthcare cost, quality, practices
- Traumatic Brain Injury and Neurovascular Disturbances
University of Pittsburgh
2016-2025
Odense University Hospital
2025
University of Pittsburgh Medical Center
2011-2024
UPMC Health System
2024
Vitalant
2019-2023
University of Pennsylvania
2023
Mayo Clinic in Florida
2023
New York University
2023
Tel Aviv University
2022
Texas Health Dallas
2022
After a person has been injured, prehospital administration of plasma in addition to the initiation standard resuscitation procedures environment may reduce risk downstream complications from hemorrhage and shock. Data large clinical trials are lacking show either efficacy or risks associated with transfusion setting.
Abstract Introduction The use of low titer O whole blood (LTOWB) has expanded although it remains unclear how many civilian trauma centers are using LTOWB. Methods We analyzed data on LTOWB recipients in the American College Surgeons Trauma Quality Improvement Program (TQIP) database 2020–2021. Unique facility keys were used to determine number that period. Results A total 16,603 patients received TQIP between 2020 and 2021; 6600 2020, 10,003 2021. facilities reported went from 287/779 (37%)...
Febrile non-hemolytic transfusion reactions (FNHTRs) are a common complication of platelet concentrate (PC) and RBC transfusions, usually ascribed to cytokines released by WBCs perhaps the platelets themselves during storage. Prestorage WBC reduction should abrogate accumulation these reducing number FNHTRs.A retrospective analysis FNHTR PCs RBCs before universal (PrUR) (July 1997-January 1998 for PCs, July 1997-July 1999 RBCs) after its introduction (PoUR) (February 1998-August 2001 PC,...
The use of cold-stored low-titer group O whole blood (LTOWB) for civilian trauma patients is gaining popularity. However, hemolysis might occur among non-group recipients. This study evaluated the serologic safety transfusing up to 4 units LTOWB.Hypotensive male and at least 50-year-old female who received leukoreduced, uncrossmatched, O+, (<50 anti-A anti-B), platelet-replete during initial resuscitation were included in this prospective, observational study. Biochemical markers measured on...
Use of universally ABO-compatible group AB plasma for trauma resuscitation can be challenging due to supply limitations. Many centers are now using A during the initial traumatically injured patients. This study was undertaken evaluate impact this practice on mortality and hospital length stay (LOS).Seventeen in patients unknown ABO participated study. Eligible were A, B, who received at least 1 unit plasma. Data collected included patient sex, age, mechanism injury, Trauma Injury Severity...
No transfusion reactions were reported.The median (IQR) time from ED admission to the start of WB was 15 (14-77) minutes, compared with 303 (129-741) minutes (P < .001)for administration at least 1 unit RBCs, plasma, and platelets in historical cohort (Figure).Discussion | To our knowledge, this is first pediatric civilian trauma patients receive during resuscitation.These preliminary data suggest that up 20 mL/kg safe children severe injuries; there no evidence hemolysis non-group O...
<h3>Importance</h3> Prehospital plasma administration improves survival in injured patients at risk for hemorrhagic shock and transported by air ambulance. Traumatic brain injury (TBI) is a leading cause of death following trauma, but few early interventions improve outcomes. <h3>Objective</h3> To assess the association between prehospital with TBI. <h3>Design, Setting, Participants</h3> The Air Medical Plasma (PAMPer) trial was pragmatic, multicenter, phase 3, cluster randomized clinical...
After the transfusion of RhD-positive red blood cell (RBC)-containing products to an RhD-negative woman childbearing potential (WCP) during trauma resuscitation, there are several events that must occur for WCP have a future pregnancy affected by hemolytic disease fetus and newborn (HDFN). This study identified quantitated frequency novel event in sequence from resuscitation HDFN outcome, is, development high titer anti-D among women who were D-alloimmunized.
From the Department of Pathology (M.H.Y.), University Pittsburgh, Pennsylvania; U.S. Army Institute Surgical Research (A.P.C., P.C.S.), JBSA-FT Sam Houston, Texas; and Division Critical Care Medicine, Pediatrics (P.C.S.), Washington in St. Louis, St Missouri. Submitted: October 3, 2017, Revised: December 11, Accepted: 12, Published online: 28, 2017. This article was presented at 2017 RDCR Symposium, June Os, Norway. Address for reprints: Mark Yazer, MD, 3636, Blvd Allies, PA 15213; email:...
The mechanical fragility index (MFI) is an in vitro measurement of the extent RBC sublethal injury. Sublethal injury might constitute a component storage lesion, thus MFI was determined serially during routine storage.Leucoreduced AS-5- and SAGM-preserved RBCs were stored under blood bank conditions. (MF) each unit measured storage.For both AS-5 SAGM units, male female demonstrated statistically significant increases storage. significantly lower units compared to throughout Female had vs. at...
If "bridging" to allo-transplantation (Tx) is be achieved by a pig liver xenograft, adequate hepatic function needs assured.We have studied in baboons after Tx of livers from alpha1,3-galactosyltransferase gene-knockout (GTKO, n=1) or GTKO pigs transgenic for CD46 (GTKO/CD46, n=5). Monitoring was tests and coagulation parameters. Pig-specific proteins the baboon serum/plasma were identified Western blot. In four baboons, factors measured. The results compared with values healthy humans,...
BACKGROUND As patient blood management becomes more widespread, fewer red cell (RBC) units have been transfused. This multinational study evaluated changes in center RBC distributions. STUDY DESIGN AND METHODS Data on number and ABO D groups of distributions were obtained from several large American centers national or provincial services (NPBS) fiscal year (FY) 2010 through FY2014. Due to relatively larger numbers differences between the Japanese Red Cross other NPBS, data not included...
Introduction Recent evidence demonstrated that prehospital plasma in patients at risk of hemorrhagic shock was safe for ground transport and resulted a 28-day survival benefit air medical patients. Whether any beneficial effect varies across injury mechanism remains unknown. Methods We performed secondary analysis using harmonized data set derived from two recent randomized trials. Identical inclusion/exclusion criteria primary/secondary outcomes were used the Prehospital time, arrival...
Objective: To determine the feasibility, efficacy, and safety of cold stored compared to room temperature platelet transfusion in patients with traumatic brain injury. Summary Background Data: Data demonstrating efficacy are lacking following Methods: A phase 2, randomized, open label, clinical trial was performed at a single U.S. trauma center. Traumatic injured positive imaging need for received up two apheresis units platelets out 14 days versus standard care transfusion. The primary...
INTRODUCTION Hemorrhage is a leading cause of death in pediatric patients. Accumulating data suggest that low-titer group O whole blood (LTOWB) improves clinical outcomes the population. We examined what ratio LTOWB to total product conferred survival benefit transfused trauma METHODS retrospectively cohort injured subjects younger than 18 years from Trauma Quality Improvement Program database who received any quantity and no documented prehospital cardiac arrest. created variable...
Abstract Introduction The rate of D‐alloimmunization amongst RhD‐negative recipients RhD‐positive red blood cell (RBC) transfusions is not certain. Recipients with a short duration between the index transfusion and last antibody detection test that did show anti‐D might become D‐alloimmunized in future. A regression model was developed to predict how often such patients develop future help account for immunohematological uncertainty accompanies having serological follow up periods. Methods...
Abstract Background As low titer group O whole blood (LTOWB) increases in popularity, centers are finding innovative ways of maintaining the supply. One potential way is collecting LTOWB from parous female donors without testing for HLA antibodies. This silico simulation predicted risk an unit containing antibody and subsequent HLA‐incompatible transfusion. Methods An bank with 1 million units was simulated consisting male, nulliparous, donors. The proportion each donor type modeled after...
Abstract Introduction Data on the correlation between transfusion volumes and trauma mortality are limited. The association total number of red blood cell (RBC) low titer group O whole (LTOWB) units, as well volume all transfused products that were administered up to 4‐h after admission 24‐h was determined. Methods Trauma Quality Improvement Program (TQIP) datasets from 2020 2022 reviewed identify patients aged ≥15 who received any products. Receiver operating characteristic (ROC)...
Abstract Background Prehospital transfusions might provide a survival benefit for injured patients. Because blood products are scarce resource, their optimal deployment requires careful consideration. A computer model was built to explore different scenarios two blood‐carrying ambulances (mobile banks, MBBs) in the City of Pittsburgh. Study Design and Methods Mixed integer programs were used determine locations bases MBBs from amongst City's 14 ambulance bases. Then, discrete‐event...