A5043701556- Blood transfusion and management
- Blood groups and transfusion
- Blood donation and transfusion practices
- Platelet Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Smoking Behavior and Cessation
- Trauma and Emergency Care Studies
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Venous Thromboembolism Diagnosis and Management
- Tracheal and airway disorders
- Cancer Risks and Factors
- Acute Myeloid Leukemia Research
- Sepsis Diagnosis and Treatment
- Blood properties and coagulation
- Neutropenia and Cancer Infections
- Respiratory Support and Mechanisms
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Erythrocyte Function and Pathophysiology
- Cardiac Arrest and Resuscitation
- Gastrointestinal disorders and treatments
University of Oxford
2016-2025
NHS Blood and Transplant
2016-2025
Oxford University Hospitals NHS Trust
2016-2025
National Health Service
2006-2024
John Radcliffe Hospital
2015-2024
American Veterinary Medical Association
2023-2024
London School of Economics and Political Science
2011-2024
University of Helsinki
2024
Marine Institute
2022-2024
Oxford BioMedica (United Kingdom)
2013-2023
The indications for transfusing fresh‐frozen plasma (FFP), cryoprecipitate and cryosupernatant are very limited. When transfused they can have unpredictable adverse effects. risks of transmitting infection similar to those other blood components unless a pathogen‐reduced (PRP) is used. Of particular concern allergic reactions anaphylaxis, transfusion‐related acute lung injury, haemolysis from antibodies group antigens, especially A B. FFP not indicated in disseminated intravascular...
The ability to determine fetal RhD status noninvasively is useful in the treatment of RhD-sensitized pregnant women whose partners are heterozygous for gene. recent demonstration DNA maternal plasma raises possibility that genotyping may be possible with use plasma.
To describe the patient characteristics, diagnoses and clinical outcomes of patients presenting with acute upper gastrointestinal bleeding (AUGIB) in 2007 UK Audit.Multi-centre survey.All hospitals admitting AUGIB.All adults (>16 years) or to AUGIB between 1 May 30 June 2007.Data on 6750 (median age 68 was collected from 208 participating hospitals. New admissions (n=5550) were younger 65 than inpatients (n=1107, median 71 years), less co-morbidity (any 46% vs 71%, respectively). At...
Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence spread of antibiotic-resistant clones, particularly within hospital environment. Despite this, basic questions about evolution population biology species, with regard extent impact homologous recombination, remain unanswered. We address these issues through analysis sequence data obtained from characterization by multilocus typing (MLST) 334 isolates S. aureus, recovered...
<h3>Importance</h3> Blood transfusion is one of the most frequently used therapies worldwide and associated with benefits, risks, costs. <h3>Objective</h3> To develop a set evidence-based recommendations for patient blood management (PBM) research. <h3>Evidence Review</h3> The scientific committee developed 17 Population/Intervention/Comparison/Outcome (PICO) questions red cell (RBC) in adult patients 3 areas: preoperative anemia (3 questions), RBC thresholds (11 implementation PBM programs...
ABSTRACT Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity immunosuppressed individuals. Using recently described technique staining antigen-specific CD8 + T cells with peptide-HLA tetrameric complexes, we have demonstrated high levels specific for HCMV peptides and show that this may exceed 4% donors. Moreover, by tetramers combination antibodies to cell surface markers intracellular cytokines, demonstrate...
The effectiveness of platelet transfusions to prevent bleeding in patients with hematologic cancers remains unclear. This trial assessed whether a policy not giving prophylactic was as effective and safe providing prophylaxis.
Previously active in the mid-1990s, Canadian Airway Focus Group (CAFG) studied unanticipated difficult airway and made recommendations on management a 1998 publication. The CAFG has since reconvened to examine more recent scientific literature management. Group's mandate for this article was arrive at updated practice of unconscious/induced patient whom or failed tracheal intubation is encountered.Nineteen clinicians with backgrounds anesthesia, emergency medicine, intensive care joined...
This is the first UK national guideline to concentrate on acute lower gastrointestinal bleeding (LGIB) and has been commissioned by Clinical Services Standards Committee of British Society Gastroenterology (BSG). The Guidelines Development Group consisted representatives from BSG Endoscopy Committee, Association Coloproctology Great Britain Ireland, Interventional Radiology, Royal College Radiologists, NHS Blood Transplant a patient representative. A systematic search literature was...
Appropriate planning is crucial to avoid morbidity and mortality when difficulty anticipated with airway management. Many guidelines developed by national societies have focused on management of encountered in the unconscious patient; however, little guidance appears literature how best approach patient an difficult airway. To review this other subjects, Canadian Airway Focus Group (CAFG) was re-formed. With representation from anesthesiology, emergency medicine, critical care, CAFG members...
Background: Estimation suggests that at least 4 million people die, annually, as a result of chronic respiratory disease (CRD). The Global Alliance against Chronic Respiratory Diseases (GARD) was formed following mandate from the World Health Assembly to address this serious and growing health problem. Objectives: To investigate prevalence CRD in Russian symptomatic patients evaluate frequency major risk factors for Russia. Methods: A cross-sectional, population-based epidemiological study...
<h3>Objective</h3> Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, including endoscopy, radiology surgery as well clinical <h3>Design</h3> Multicentre audit adults presenting with LGIB to hospitals over 2 months in 2015. Consecutive cases were prospectively enrolled by teams followed 28 days. <h3>Results</h3> Data 2528...
S ummary . Recent studies have shown that the incidence of alloimmunization due to repeated platelet transfusions from random donors may be reduced by use leucocyte‐poor blood components. These results were confirmed this study, where 16% patients with acute leukaemia undergoing initial chemotherapy and receiving components developed lymphocytotoxic antibodies, compared 48% in a control group standard (non‐leucocyte‐depleted) In third group, who received HLA‐matched platelets, none...
BACKGROUND: Fresh‐frozen plasma (FFP) is given to patients across a range of clinical settings, frequently in association with abnormalities standard coagulation tests. STUDY DESIGN AND METHODS: A UK‐wide study FFP transfusion practice was undertaken characterize the current patterns administration and evaluate contribution pretransfusion RESULTS: total 4969 transfusions 190 hospitals were analyzed, which 93.3% adults 6.7% children or infants. most intensive‐treatment high‐dependency units...
<h3>Objectives</h3> To examine the use of endoscopy in UK for acute upper gastrointestinal bleeding (AUGIB) and compare with published standards. assess organisation services AUGIB UK. relationship between outcomes out hours (OOH) service provision. <h3>Design</h3> Multi-centre cross sectional clinical audit. <h3>Setting</h3> All hospitals accepting admissions AUGIB. <h3>Patients</h3> adults (≥16 yrs) presenting 1st May 30th June 2007. <h3>Data Collection</h3> A custom designed web-based...
Background Transillumination of the soft tissue neck using a lighted stylet (lightwand) is an effective and safe intubating technique. A newly designed lightwand (Trachlight) incorporates modifications to improve brightness light source as well flexibility. The goal this study was determine effectiveness safety device in trachea elective surgical patients. Methods Healthy patients were studied. Patients with known or potential problems intubation excluded. During general anesthesia, tracheas...
Summary The incidence of lymphopenia, thrombocytopenia and neutropenia was studied in 105 homosexual men with HIV infection. Lymphopenia common patients AIDS (75%), but its PGL (24%) not significantly different from that asymptomatic anti‐HIV positive (15%) men. Neutropenia were found or PGL. homosexuals. study suggests the thombocytopenia these due to autoimmune destruction neutrophils platelets.