A5078865207- Blood groups and transfusion
- Platelet Disorders and Treatments
- Advanced Breast Cancer Therapies
- Chemistry and Stereochemistry Studies
- Language, Linguistics, Cultural Analysis
- Global Maritime and Colonial Histories
- Radiomics and Machine Learning in Medical Imaging
- Linguistic, Cultural, and Literary Studies
- Advanced Optical Sensing Technologies
- Asian Geopolitics and Ethnography
- Diverse Scientific and Economic Studies
- Blood disorders and treatments
- Complement system in diseases
- Medical Imaging Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Biosensors and Analytical Detection
- African history and culture analysis
- Blood transfusion and management
- Blood properties and coagulation
- Blood donation and transfusion practices
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Cancer Immunotherapy and Biomarkers
- Italian Fascism and Post-war Society
- Protein Degradation and Inhibitors
Pacific Northwest National Laboratory
2022-2024
Universidade dos Açores
2021
Universidade Estadual de Campinas (UNICAMP)
2008-2020
Hospital de Clínicas da Unicamp
2007-2009
Children's Hospital of Philadelphia
2006-2009
University of Pennsylvania
2006-2009
Novartis (Italy)
2009
Instituto Adolfo Lutz
2009
Hospital Universitario Nuestra Señora de Candelaria
2007
Justus-Liebig-Universität Gießen
2006
With the Arctic rapidly changing, needs to observe, understand, and model changes are essential. To support these needs, an annual cycle of observations atmospheric properties, processes, interactions were made while drifting with sea ice across central during Multidisciplinary Observatory for Study Climate (MOSAiC) expedition from October 2019 September 2020. An international team designed implemented comprehensive program document characterize all aspects system in unprecedented detail,...
Abstract The Cloud, Aerosol, and Complex Terrain Interactions (CACTI) field campaign was designed to improve understanding of orographic cloud life cycles in relation surrounding atmospheric thermodynamic, flow, aerosol conditions. deployment the Sierras de Córdoba range north-central Argentina chosen because very frequent cumulus congestus, deep convection initiation, mesoscale convective organization uniquely observable from a fixed site. C-band Scanning Atmospheric Radiation Measurement...
Abstract Management of Sepsis would greatly benefit from the incorporation simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected non-infected patients, provide information about prognosis organ-specific damage be accessible to most healthcare services. The immature platelet fraction (IPF) reticulocyte (IRF) are analytical parameters complete blood count, that have been studied as several inflammatory conditions. Recently, study...
Severe pancytopenia is a rare but severe complication of thyrotoxicosis. In this report, we describe four patients with Graves' disease who presented at diagnosis. Methimazole (30–40 mg/d) or propylthiouracil (400 restored normal hematopoiesis in three the patients. The remaining patient evolved to aplastic anemia under therapy methimazole (60 mg/d), had an increased peripheral blood count that almost reached values after radioiodinetherapy and standard immunosuppressive treatment...
Dengue cases have been classified according to disease severity into dengue fever (DF) and hemorrhagic (DHF). Although DF is considered a non-severe manifestation of dengue, it has recently demonstrated that represents heterogeneous group patients with varied clinical complications grades severity. Particularly, bleeding complications, commonly associated DHF, can be detected in half the DF. frequent complication, causes bleedings not fully addressed. Thus, aim this study was perform...
The aim of this study was to correlate ABO groups with plasma levels factor VIII (FVIII), von Willebrand (VWF:Ag), and ristocetin cofactor (VWF:RCo). Serological molecular tests defined blood from 114 donors (10 AA, 10 BB, AB, AO1, BO1,16 O1O1, 20 A2O1, A2B, 4 A3O1, 3 AxO1, 1 BelO1). VWF:Ag, FVIII VWF:RCo observed in rare subgroups (A3O1, BelO1) were similar the values found O1O1 group. However, these factors significantly higher A2O1 than (VWF:Ag p=0.01; p=0.04; p<0.001). Strong...
BACKGROUND: The tests used for anemia screening in blood donors are based on fingerstick samples, leading to discomfort and complaints. aim of this study was analyze the feasibility occlusion spectroscopy method banks compare with hemoglobinometer hemoglobin (Hb) determination an automatic analyzer. STUDY DESIGN AND METHODS: enrolled 205 consecutive volunteer donors. Samples were collected by venous punction determine Hb level a Hemocue Hb201+ (Hb‐F) analyzer (Hb‐V) noninvasive using NBM200...
To identify the occurrence and causes of platelet refractoriness in oncohematologic patients. Platelet (unsatisfactory post-transfusion increment) is a severe problem that impairs treatment patients not routinely investigated most Brazilian services. Forty-four episodes concentrate transfusion were evaluated 16 according to following parameters: corrected count increment, clinical conditions detection anti-platelet antibodies by immunofluorescence test (PIFT) panel reactive against human...
The human platelet antigen (HPA) systems are related to immune disorders as well the development of occlusive vascular disease. Several distinct biallelic HPA known, and a heterogeneous distribution alleles has been described among ethnic groups. In this study we genotyped 320 carefully selected individuals from three groups in Brazil (Caucasians, Blacks Amazonian Indians) for HPA-1, -2, -3, -4 -5 systems. A similar prevalence all was found Brazilians Caucasian Black descent. These data...
Polymorphisms of platelet membrane glycoproteins such as human antigen (HPA)-1b, HPA-2b, the -5T/C Kozak sequence and C807T have been described risk factors for vascular disease. Vaso-occlusion episodes are a common feature sickle cell anaemia (SCA), leading to complications stroke, acute chest syndrome, avascular head femur necrosis priapism. Complex interactions involved in vaso-occlusion, activated platelets may play an important role. These data raised question whether polymorphisms...
Background The SARS‐CoV‐2 pandemic is having an impact on blood supply. This situation has led to new strategies minimize the product availability. Methods Hemocentro UNICAMP, a regional reference centre in Brazil, established availability strategies, respecting national and local measures decrease transmission of SARS‐CoV‐2. Measures include booking donation appointments, reorganization areas permit social distancing, pre‐reception reinforce donor instructions, antisepsis donors’ hands with...
BACKGROUND: Dengue is a mosquito‐borne viral disease with an increasing incidence worldwide. Thrombocytopenia common finding in dengue virus (DV) infection; however, the underlying mechanisms remain unknown. CASE REPORT: Here we provide first evidence of case antibody formation against ADAMTS13 (ADAMTS13 inhibitor) course severe acute DV infection resulting thrombotic microangiopathy (TMA). The patient presented classical symptoms (positive epidemiology, high fever, myalgia, predominantly...
Summary We report a new and efficient methodology of labelling red blood cells, in order to investigate the expression anti‐A antigen, employing luminescent semiconductor nanocrystals. Highly stable core‐shell cadmium sulphide/cadmium hydroxide [CdS/CdS(OH) 2 ] colloidal particles were obtained nanometre size range. The surface these was characterized by using monoclonal antibody via one‐step glutaraldehyde cross‐linking procedure, followed conjugation cells groups A + , O . Laser scanning...
BACKGROUND: Neonatal thrombocytopenia (NT) occurs in 0.5 to 0.9% of unselected Caucasian newborns. However, the prevalence this complication other populations is unknown. In study prevalence/causes NT was determined Brazilian newborns, a population characterized by admixture among Indigenous, Africans, and Caucasians. STUDY DESIGN: A prospective carried out 3‐year period, determine causes cord blood samples. Genotyping for HPA 1‐5 systems performed pairs mother/neonates with without...
Argon plasma coagulation (APC) is a noncontact technique of electrocoagulation in which energy transmitted via ionized argon gas flow. The tip the catheter should be kept between 1 mm and 3 away from mucosa. APC has become increasingly popular for treating gastric antral vascular ectasia (GAVE). Its main advantage that more superficial, thus reducing risk complications [1].
Abstract The Consortium for Blood Group Genes is a worldwide organization whose goal to have vehicle interact, establish guidelines, operate profi ciency program, and provide education laboratories involved in DNA RNA testing the prediction of blood group, platelet, neutrophil antigens. Currently, consortium operates with representatives from Brazil, Canada, United States. Membership voluntary expectation that members actively contribute discussions involving group genetics. This year...
Classic immunohematology approaches, based on agglutination techniques, have been used in manual and automated laboratory routines. Red blood cell (RBC) depends intermolecular attractive forces (hydrophobic bonds, Van der Walls, electrostatic hydrogen bonds) repulsive interactions (zeta potential). The aim of this study was to measure the force involved RBC aggregation using double optical tweezers, normal serum, presence erythrocyte antibodies associated potentiator solutions (Dextran, low...
Scott syndrome is a rare bleeding disorder due to an impaired exposure of phosphatidilserine on the platelet membrane, compromising procoagulant activity, thrombin generation and, thus, clot formation. We report case 17-year-old female adolescent with episodes unknown cause. She had normal coagulation, but altered aggregation under arteriolar flow, indicating dysfunction. Furthermore, expression Annexin V was markedly reduced and diagnosis established. treated transfusions demonstrated...
We report a new methodology for red blood cell antigen expression determination by simple labeling procedure employing luminescent semiconductor quantum dots. Highly and stable core shell cadmium sulfide/cadmium hydroxide colloidal particles are obtained, with predominant size of 9 nm. The core-shell dots functionalized glutaraldehyde conjugated to monoclonal anti-A antibody target antigen-A in membranes. Erythrocyte samples groups A+, A, O+ used this purpose. Confocal microscopy images show...
Thrombocytopenia is common in patients with myelodysplastic syndromes (MDS) and immune destruction of platelets could be an important factor for its occurrence. We prospectively analyzed platelet-associated IgG (PAIgG) through platelet immunofluorescence test (PIFT), mean volume (MPV), size deviation width (PDW) glycocalicin index (GCI) 54 MDS, classified according to the International Prognostic Scoring System (IPSS). (platelet count<100×10(9)/L) was correlated a higher amount PAIgG,...
OBJECTIVE—We studied the association between Gly972Arg polymorphism in insulin receptor substrate-1 (IRS-1) and birth weight a population-based sample of Brazilian newborns. RESEARCH DESIGN AND METHODS—We 194 newborn children with adequate gestational age to identify using PCR—restriction fragment length analysis. RESULTS—The data showed that was lower newborns IRS-1 compared control subjects (3,141 ±31.8 vs. 3,373 ±80.3 g, P &lt; 0.008). The results also frequency this increased...
Background and Objectives Transfusion support for immune‐mediated platelet refractoriness ( PR ) is clinically challenging, technically laborious costly. The development of ‘Ep HLA /EpVix software’ has been used successfully to select kidney donors. Here, we sought evaluate this new software as a tool virtual crossmatch (VxM). Materials Methods This prospective study from 2007 2014 patients in tertiary hospital. Platelet components selected by HLAM atchmaker program were crossmatched Ep...
Haemolysis caused by passive ABO antibodies is a rare transfusional complication. We report case of severe haemolytic reaction in 38-year-old man (blood group A) with lymphoma who had received one red blood cell (RBC) unit O. After transfusion 270 mL, the patient experienced fever, dyspnoea, chills and back pain. On following morning he was icteric pale. Haptoglobin inferior to 5.8 mgdL(-1), haemoglobin not increased lactate dehydrogenase elevated. evident on observation patient's...