Rafaela Costa

ORCID: 0000-0003-0538-7008
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About
Contact & Profiles
Research Areas
  • Stress Responses and Cortisol
  • Adipose Tissue and Metabolism
  • Cardiovascular and exercise physiology
  • Hormonal Regulation and Hypertension
  • Exercise and Physiological Responses
  • Neuroendocrine regulation and behavior
  • Innovative Teaching Methods
  • Nitric Oxide and Endothelin Effects
  • Olfactory and Sensory Function Studies
  • Bone fractures and treatments
  • Biomedical and Engineering Education
  • Mindfulness and Compassion Interventions
  • Problem Solving Skills Development
  • Sodium Intake and Health
  • Animal testing and alternatives
  • Cardiovascular Disease and Adiposity
  • Cardiac Health and Mental Health
  • Venous Thromboembolism Diagnosis and Management
  • COVID-19 and Mental Health
  • Empathy and Medical Education
  • Problem and Project Based Learning
  • Cardiac Arrhythmias and Treatments
  • Circadian rhythm and melatonin
  • Platelet Disorders and Treatments
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research

Centro Universitário São Camilo
2024

Universidade Estadual de Campinas (UNICAMP)
2008-2022

Methodist University of Piracicaba
2008-2015

The aim of the present article is to describe a puzzle developed for use in teaching cardiac physiology classes. presents figures phases cycle and table with five columns: cycle, atrial state, ventricular state atrioventricular valves, pulmonary aortic valves. Chips are provided complete table. Students requested discuss which correct sequence indicating cycle. Afterward, they should chips. biology, dentistry, medicine, pharmacy, nursing graduation courses from seven institutions performed...

10.1152/advan.00116.2014 article EN AJP Advances in Physiology Education 2015-03-01

The aim of this study was to analyze the effects chronic mild unpredictable stress (CMS) on vasoconstrictor response and morphology thoracic aorta serum lipid profiles in rats. Male Sprague-Dawley rats were submitted CMS, which consisted application different stressors for 7 days per week across 3 weeks. sacrificed 15 after CMS exposure. induced supersensitivity effect phenylephrine endothelium-intact aortic rings without changes endothelium, or pre-incubated with nitric oxide (NO) synthesis...

10.1080/10253890802437779 article EN Stress 2008-12-16

The aim of this study was to evaluate vascular and metabolic effects chronic mild unpredictable stress (CMS) hypercaloric diet (HD) without carbohydrate supplementation in rats. Male Sprague-Dawley rats were randomly assigned four groups: Control, HD, CMS, HD plus CMS. CMS consisted the application different stressors for 3 weeks. killed 15 days after exposure. group presented higher plasma lipid concentrations, changes fasting glucose concentration, tolerance test, function morphology,...

10.3109/10253890.2011.601369 article EN Stress 2011-07-31

The aim of this study was to evaluate the effect an active methodology combined with a lecture on undergraduate student learning and levels stress anxiety. consisted 50-min duration, at home textbook, educational game activity, three formative assessments topic cardiac cycle. In following class, students provided saliva samples their stress, received anxiety test, then undertook exam assess understanding traditional teaching two lectures (∼2-h duration) blood pressure control systems,...

10.1152/advan.00075.2020 article EN AJP Advances in Physiology Education 2020-11-18

Polymorphisms of platelet membrane glycoproteins such as human antigen (HPA)-1b, HPA-2b, the -5T/C Kozak sequence and C807T have been described risk factors for vascular disease. Vaso-occlusion episodes are a common feature sickle cell anaemia (SCA), leading to complications stroke, acute chest syndrome, avascular head femur necrosis priapism. Complex interactions involved in vaso-occlusion, activated platelets may play an important role. These data raised question whether polymorphisms...

10.1111/j.1423-0410.2004.00536.x article EN Vox Sanguinis 2004-08-01

Abstract Introduction: Stress is considered one of the most significant health problems in modern society. It can be characterized as any changes homeostasis an individual that require adaptive response. An imbalance secretion primary stress mediators may responsible for onset and development several diseases. Thus, chronic has been recognized a risk factor depression well cardiovascular metabolic Given pathophysiological mechanisms associated with related changes, it necessary to implement...

10.1590/0103-5150.029.001.ao02 article EN cc-by Fisioterapia em Movimento 2016-03-01

We have previously shown that chronic mild and unpredictable stress (CMS) induced endothelium dysfunction insulin resistance in rats. Physical exercise is recognized to provide better glycemic control. Thus, the aim of this study was evaluate effect moderate on response oral glucose tolerance test (OGTT) rats submitted CMS. Male Sprague‐Dawley were divided into four groups: 1) Control, 2) Exercise, 3) CMS 4) Exercise plus (n=7–9). protocol consisted application different stressors, 7 days...

10.1096/fasebj.30.1_supplement.766.1 article EN The FASEB Journal 2016-04-01

Sport practice by patients with Osteogenesis Imperfecta should be encouraged, however contact sports always duly considered due to the risk of bone fractures. The authors describe clinical case a Wheelchair Basketball athlete (WB) who went Emergency Department distal radius fracture in context wrist trauma caused ball. Distal fractures typically occur high-kinetic trauma. Due increased fragility presented, this was minor receiving WB is high-impact sport, so its athletes OI must considered.

10.23911/osteogenesis_imperfecta_2024_jul article EN Revista de Medicina Desportiva informa 2024-07-01

A embolia pulmonar ocorre quando um êmbolo bloqueia as artérias pulmonares, muitas vezes como resultado de trombose venosa profunda. condição é grave, com elevada morbimortalidade e sinais clínicos inespecíficos, o que dificulta diagnóstico. Fatores risco incluem profunda prévia, imobilização prolongada obesidade, destacando a necessidade diagnóstico precoce para reduzir complicações. Este artigo objetiva analisar perfil epidemiológico da no Brasil 2013 2023, usando dados do Sistema...

10.36557/2674-8169.2024v6n11p985-999 article PT cc-by Brazilian Journal of Implantology and Health Sciences 2024-11-11

Skeletal muscle hypertrophy is an exercise-induced adaptation, particularly in resistance training (RT) programs that use large volumes and low loads. However, evidence regarding the role of rest intervals on metabolic stress muscular adaptations inconclusive. Thus, we aimed to investigate effects a strenuous RT model (jump-training) skeletal stress, considering scarce information about models for rats. We hypothesized jump-training induces influences negatively growth soleus (SOL) extensor...

10.1080/10253890.2019.1573364 article EN Stress 2019-03-12

We've developed a puzzle about the cardiac cycle to be used in Physiology classes an undergraduate course of Dentistry. This presents one table with 5 columns, which contain phase, Atrial state, Ventricular Atrium ventricular valves and Pulmonary aortic valves. Pictures phases chips are provided order complete table. The indicate: phases, options relaxed or contracted, can depending on atrial states, open closed concerning In groups, students requested meanwhile professors discuss them why...

10.1096/fasebj.27.1_supplement.lb885 article EN The FASEB Journal 2013-04-01

Aims: To investigate the effects of high-volume endurance training on stress-induced cardiometabolic perturbations.Main Methods: Rats were randomized into non-trained rats, rats submitted to training, stress, and trained stress. Endurance was applied for 8 weeks, while chronic stress at 4th, 5th, 6th weeks period. Two after last stressor stimuli, euthanized, blood heart collected biochemical tests.Key findings: Exacerbated corticosterone levels observed in both stressed groups, per se...

10.2139/ssrn.4121004 article EN SSRN Electronic Journal 2022-01-01

The aim of this study was to evaluate the effect 2h daily exposition environmental enrichment (EE) during 5 weeks on hormonal and behavioral responses induced by chronic mild unpredictable stress (CMS) applied 3 consecutive in rats. Male adult rats were divided into 4 groups: control (C), EE, CMS + EE. Depression‐like behavior evaluated forced swimming test (FST) memory Y‐maze at end protocol. One day after tests, animals killed trunk blood collected for corticosterone assay. All procedures...

10.1096/fasebj.27.1_supplement.lb726 article EN The FASEB Journal 2013-04-01

We've shown previously that chronic mild and unpredictable stress (CMUS) induced endothelium dysfunction increased renin‐angiotensin system (RAS) activity in rats. Since endothelial high RAS has been associated with insulin resistance the aim of this study was to evaluate effect losartan on response oral glucose tolerance test (OGTT) rats submitted CMUS. Male Sprague‐Dawley were divided into four groups: control, CMUS, (50mg/Kg) CMUS + (n=12/group). protocol consisted applying different...

10.1096/fasebj.26.1_supplement.869.20 article EN The FASEB Journal 2012-04-01

In the great majority of cases, halitosis is originated in mouth itself and psychological symptoms have been pointed out as one halitosis‐inducing factor. The aim this study was to evaluate, laboratory animals, effect chronic mild stress (CMS) on production volatile sulfur compounds (VSC), main component bad breath. VSC measurements were made using a portable industrial monitor (Halimeter) once week, during seven weeks, control stressed adult males Wistar rats. CMS group submitted protocol...

10.1096/fasebj.22.1_supplement.946.12 article EN The FASEB Journal 2008-03-01
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