A5069666849- Renal Transplantation Outcomes and Treatments
- Stress Responses and Cortisol
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Advanced Proteomics Techniques and Applications
- Menstrual Health and Disorders
- Hepatitis C virus research
- Cardiovascular Effects of Exercise
- Health and Wellbeing Research
- Neuroendocrine regulation and behavior
- Adenosine and Purinergic Signaling
- Transplantation: Methods and Outcomes
- Reproductive Health and Contraception
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmaceutical studies and practices
- Veterinary Pharmacology and Anesthesia
- Biosimilars and Bioanalytical Methods
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Vagus Nerve Stimulation Research
- Genetics and Physical Performance
- Diet and metabolism studies
- Isotope Analysis in Ecology
- Periodontal Regeneration and Treatments
- Hepatitis B Virus Studies
Libbs (Brazil)
2021-2024
Universidade Federal de São Paulo
2011-2021
Hospital do Rim e Hipertensão
2017
E Ink (South Korea)
2017
Juliana Kinderziekenhuis
2016
Studies have shown that stress-related catecholamines may affect cancer progression. However, little is known about catecholamine secretion profiles in head and neck patients. The present study investigated plasma norepinephrine epinephrine levels squamous cell carcinoma (HNSCC) patients with oral leukoplakia, as well their association clinicopathological biobehavioral variables anxiety symptoms. A total of 93 HNSCC 32 leukoplakia were included. Plasma measured by high performance liquid...
To investigate whether thyroid hormone (TH) interacts with the sympathetic nervous system (SNS) to modulate bone mass and structure, we studied effects of daily T3 treatment in a supraphysiological dose for 12 wk on young adult mice chronic hyperactivity owing double-gene disruption adrenoceptors that negatively regulate norepinephrine release, α(2A)-AR, α(2C)-AR (α(2A/2C)-AR(-/-) mice). As expected, caused generalized decrease areal mineral density (aBMD) WT (determined by DEXA), followed...
<i>Background/Aims:</i> Nephrotoxicity is a prominent component of the profile chemotherapeutic agents and to date proteomics has represented main technique identify protein profiles in response xenobiotic exposure. <i>Methods:</i> We made use two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization time-of-flight analysis evaluate chemotoxicity effects cisplatin (CPT) carboplatin (CB) on proteins from human renal proximal tubule epithelial...
High-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was evaluate the effect RT on left ventricle proteome, identify pathways involved harmful induced by protocol. Male Wistar rats were randomized into 2 groups: Trained (T) Sedentary (S). Animals from T group trained for 6weeks, then all animals...
Breast cancer is the most common malignancy in Brazilian women, with 66,280 new cases 2020 (with 20% overexpressing human epidermal growth factor receptor 2 [HER2]). The trastuzumab biosimilar was first oncology approved Brazil for HER2-positive breast treatment. This study aimed to assess current level of knowledge biosimilars, comfort use, extrapolation indications, and switching practices among oncologists Brazil.A 24-question survey developed using an online platform that sought...
To test the effects of chronic-stress on cardiovascular system, model chronic mild unpredictable stress (CMS) has been widely used. The CMS protocol consists random, intermittent, and exposure laboratory animals to a variety stressors, during 3 consecutive weeks. In this study, we tested hypothesis that leads left ventricle microcirculatory remodeling can be attenuated by angiotensin II receptor blockade. Male Sprague-Dawley rats were randomly assigned into four groups: Control, Stress,...
The hypothalamus plays a pivotal role in numerous mechanisms highly relevant to the maintenance of body homeostasis, such as control food intake and energy expenditure. Impairment these has been associated with metabolic disturbances involved pathogenesis obesity. Since rodent species constitute important models for metabolism studies rat is poorly characterized by proteomic strategies, we performed experiments aimed at constructing two-dimensional gel electrophoresis (2-DE) profile...
Local activation of the renin–angiotensin system (RAS) has been implicated in pathogenesis several renal disorders. In this study we investigated how chronic kidney disease (CKD) modulates RAS components an experimental model. Male Wistar rats were divided into three groups: sham, nephrectomized, and nephrectomized receiving losartan. Chronic animals presented decreased N-domain angiotensin-converting enzyme (ACE) activity but overexpression ACE urine. Remnant kidneys high angiotensin II...
In Brazil, where approximately 48.7 million women are of reproductive age, understanding contraceptive practices is essential for addressing public health challenges. This study evaluated into the knowledge, usage, and perceptions methods among Brazilian women, highlighting influence socioeconomic demographic factors on their choices.
Contrast Media is used in angiography, urography and tomography.It has been reported that contrast media nephrotoxicity incidence 50% higher patients with diabetic nephropathy undergoing coronary angiography approximately 15% of these developed renal failure.Proteomic analyses are a promising tool to study pathophysiology.In the future identification biomarkers diseases will develop therapeutic targets decrease damage acute failure.To identify proteins were up or down-regulated immortalized...
This study investigates the adequacy of initial everolimus (EVR) dose, with and without calcineurin inhibitors (CNI), in kidney transplant recipients.This retrospective cohort analysis involved data from 305 recipients participating 3 randomized trials receiving reduced dose cyclosporin A (CsA) combined EVR 0.75 mg BID (CSA/EVR0.75, N = 32) or 1.5 (CSA/EVR1.5, 31), tacrolimus (TAC) (TAC0.05/EVR1.5, 83), standard TAC (TAC0.1/EVR1.5, 93), (EVR1.5, 66) introduction after day 5. The based on...
Diabetes mellitus (DM) is a metabolic syndrome and mainly characterized by chronic hyperglycemia. In DM, developing diabetic nephropathy major complication. Several studies have shown that Aloe vera (AV) exerts beneficial effects on DM. Proteomic analysis has long been used to systematically study the group of proteins are being expressed in given situation. Therefore, this study, we aimed evaluate effect butanolic fraction AV (ABF) kidneys type 1 DM rats through proteomic order elucidate...
The chronic mild and unpredictable stress (CMS) protocol induces insulin resistance, dyslipidemia, oxidative endothelial dysfunction in rats. Regular physical exercise is an effective non-pharmacological tool for the treatment of disorders induced by stress. aim was to evaluate role training on hormonal metabolic changes triggered CMS. Forty male Sprague-Dawley rats were randomized into: Control, Stress, Exercise, Exercise + submitted CMS or 8-week treadmill (50-70% maximal test). In 4 th ,...
Previous studies from our laboratory have demonstrated that chronic diabetes in rats results cardiomyopathy, associated with sympathetic nervous system (SNS) hyperactivity. On the other hand, it is well known beneficial cardiovascular effects of exercise training are due part to normalization outflow and improvement responsiveness myocardium autonomic stimulation. Recently, resistance (RT) has been recognized as a useful therapeutic tool for treatment diseases similar aerobic exercise,...
Kidney transplant is the best treatment for patients with end stage renal failure. Acute rejection (AR) major impediment to success in transplantation. We aimed identify biomarkers candidates acute using plasma LC‐MS E . Analysis was performed from 25 stable graft function ‐ control group (Ct) and 9 (Rej). have detected 19 proteins overexpressed Rej compared Ct group, 02 were underexpressed 04 that present only group. Among we selected 03 AR this model of graft. This overexpression confirmed...
Diabetes mellitus (DM) is recognized as a leading cause of chronic kidney disease and end‐stage renal failure. The local increase components Renin‐Angiotensin System has been implied in different hypertension pathogenesis. In our laboratory, we observed N‐domain ACEs isoforms with 190 65 kDa urine healthy subjects, 90 were detected hypertensive patients, suggesting that the ACE could be possible genetic marker hypertension. aim to associate dysfunctions system alterations protein expression...
Catecholamines (CA) are produced by mesangial cells (MC), and their levels increased in diabetes. The aim was to asses the effect of diabetes duration on production/release CA‐dopamine (DA), epinephrine (EP) norepinephrine (NE)‐in cultured MC. Male Wistar rats were randomized into Control, Diabetes 3M (3 months diabetes) 4M (4 groups. Rats made diabetetic (streptozotocin, 50mg/Kg) after 3 or 4 months, kidneys excised for glomeruli isolation. MC DMEM, CA extracted quantified high performance...
Proteomic techniques are a powerful tool in nephrology research and allows the identification of important biomarkers. Using two‐dimensional polyacrilamide gel electrophoresis (2‐DE), we identified an alteration protein expression human renal tubular epithelial cells (HK‐2) induced by treatment with anticancer drugs. HK‐2 were randomized control (CT‐not treated), cisplatin (CPT‐100 µM) carboplatin (CB‐50 µM). Sample (500 µg) was applied to IPG strip (pH 3.0‐ 10.0), ran under denaturing...