A5088382884- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Tumors and Oncological Cases
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Oral and gingival health research
- Viral-associated cancers and disorders
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Lymphoma Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Oral health in cancer treatment
- Oral and Craniofacial Lesions
- Fungal Infections and Studies
- Palliative and Oncologic Care
- Head and Neck Surgical Oncology
- Nail Diseases and Treatments
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Autoimmune and Inflammatory Disorders
Universidade Estadual Paulista (Unesp)
2015-2025
Centro Universitario Toledo
2016-2025
Center for Clinical Research (United States)
2014-2018
New York University
2014-2017
RELX Group (United States)
2016
Dialyse Centrum Groningen
2016
Weatherford College
2016
Florida State University
2016
Fundação Faculdade de Odontologia
2012-2015
Patients with oral cancer can have high psychological distress levels, but the effects of stress-related hormones on cells and possible mechanisms underlying these relationships are unknown. In this study, we investigated interleukin-6 (IL-6) secretion proliferation squamous cell carcinoma (OSCC) cells. The norepinephrine (NE), cortisol were studied in SCC9, SCC15, SCC25 isoproterenol SCC9 Real-time PCR studies revealed constitutive β1- β2-adrenergic receptors (β-ARs) expression results...
Objectives Dysregulation of the hypothalamus–pituitary–adrenal axis has been observed in patients with cancer. This cross-sectional study investigated whether oral and oropharyngeal squamous cell carcinoma (SCC) show changes cortisol levels saliva plasma compared three control groups, evaluated its correlation clinicopathological data. Methods Salivary 34 SCC were hormonal 17 patients, leukoplakia 27 smokers and/or drinkers 25 healthy volunteers. Multivariate analysis was used to evaluate...
Cancer pain creates a poor quality of life and decreases survival. The basic neurobiology cancer is poorly understood. Adenosine triphosphate (ATP) the ATP ionotropic receptor subunits, P2X2 P2X3, mediate in animal models; however, it unknown whether this mechanism operates human, if so, what relative contribution P2X2- P2X3-containing trimeric channels to is. Here, we studied head neck squamous cell carcinoma (HNSCC), which causes highest level function-induced other types cancer. We show...
Studies have shown that stress-related catecholamines may affect cancer progression. However, little is known about catecholamine secretion profiles in head and neck patients. The present study investigated plasma norepinephrine epinephrine levels squamous cell carcinoma (HNSCC) patients with oral leukoplakia, as well their association clinicopathological biobehavioral variables anxiety symptoms. A total of 93 HNSCC 32 leukoplakia were included. Plasma measured by high performance liquid...
Purpose Although there is a growing body of evidence showing the effects stress-related catecholamines on oral cancer progression, to date are no studies that have investigated whether squamous cell carcinoma (OSCC) cells can produce these hormones and this phenomenon modulated by tobacco-related nitrosamines. Methods In study, we keratinocytes (HaCaT) OSCC-derived lines (SSC9 SCC25) secrete neurotransmitter norepinephrine, as well tobacco carcinogen...
ABSTRACT Background This exploratory cross‐sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, psychological variables in patients head neck squamous cell carcinoma (HNSCC). Patients Methods Sleep problems from 132 HNC were assessed before starting oncological treatment through the questionnaires Pittsburgh Quality Index (PSQI), Insomnia Severity (ISI), Epworth Sleepiness Scale (ESS),...
There are few clinical studies focusing on treatment outcomes of lip cancer. This study investigated the clinicopathologic variables a large sample patients with squamous cell carcinoma (LSCC) treated in reference head and neck cancer center for past 25 years analyzed influence these outcomes.This retrospective cohort reviewed records LSCC. Epidemiologic data were age, gender, ethnicity, type occupation, tobacco smoking, alcohol consumption, comorbid conditions, family history....
Encephalopathy is one of the most frequent neurological complications severe Coronavirus Disease 2019 (COVID-19) patients. Cytokine storm and sepsis, hypercatabolic states, use furosemide dialytic therapy represent risk factors for thiamine deficiency are also found in patients with COVID-19. In this retrospective case series, we report clinical findings fifteen COVID-19-associated Wernicke (WE) their response to treatment intravenous thiamine. All had encephalopathy, 67% displaying at least...
Cancer patients may have a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and abnormal secretion cortisol. Increased cortisol levels been associated with worse prognosis in different types tumors. Although anxiety depression can trigger an secretion, little is known regarding influence these emotional disorders on HPA cancer when evaluating together demographic, clinicopathological biobehavioral variables. This cross-sectional study analyzed pre-treatment plasma 133 oral...
This study investigated whether norepinephrine (NE) and epinephrine (E) interfere in the response of head neck squamous cell carcinoma (SCC) lines to cisplatin explored mechanisms chemoresistance. Head SCC-derived SCC-9, Cal27, SCC-25, FaDu were stimulated with NE or E treated inhibitory concentration for 24 h. As adrenergic receptors (ADRB) inhibition, cells propranolol. The results showed that, when combined NE, effectiveness against SCC-9 Cal27 but not SCC-25 notably reduced. did affect...
Social isolation has affected a large number of people and may lead to impairment physical mental health. Although stress resulting from social increase cancer progression, its interference on tumorigenesis is poorly known. In this study, we used preclinical model evaluate the effects chemically induced oral carcinogenesis. Sixty-two 21-day-old male Wistar rats were divided into isolated grouped groups. After 90 days age, both groups underwent carcinogenesis with 4-nitroquinoline 1-oxide...