A5070526244- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Lipoproteins and Cardiovascular Health
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Renal Transplantation Outcomes and Treatments
- Clostridium difficile and Clostridium perfringens research
- Retinal Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced Glycation End Products research
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Sodium Intake and Health
- Blood properties and coagulation
- Inflammasome and immune disorders
- Protein Hydrolysis and Bioactive Peptides
- Heme Oxygenase-1 and Carbon Monoxide
- Urinary Bladder and Prostate Research
- Birth, Development, and Health
- Diet and metabolism studies
- Protease and Inhibitor Mechanisms
- Apelin-related biomedical research
Universidade Federal de São Paulo
2013-2025
Universidade de São Paulo
2018-2024
Institute of Biomedical Science
2024
Hospital do Rim e Hipertensão
2018
Asahi University
2000
Hamamatsu University School of Medicine
1991-1993
Butyrate is a short‐chain fatty acid derived from the metabolism of indigestible carbohydrates by gut microbiota. contributes to homeostasis, but it may also control inflammatory responses and host physiology in other tissues. inhibits histone deacetylases, thereby affecting gene transcription, signals through metabolite‐sensing G protein receptor (GPR)109a. We produced an mAb mouse GPR109a found high expression on podocytes kidney. Wild‐type Gpr109a –/– mice were induced develop nephropathy...
Acute kidney injury (AKI) is considered an inflammatory disease in which toll-like receptors (TLRs) signaling pathways play important role. The activation of TLRs results production several cytokines leading to further renal damage. In contrast, are key players on autophagy induction, associated with a protective function cisplatin-induced AKI. Hence, the present study aimed evaluate specific participation TLR2 and TLR4 molecules development Complementarily, we also investigated link between...
Autophagy, a conserved catabolic process, is critical for cellular homeostasis and its dysregulation has been implicated in number of conditions including hypertension, obesity bladder dysfunctions. The autophagy inducer trehalose shown promise treating diseases; however, some studies have reported detrimental effects vascular tissue under health conditions. In the bladder, remain unclear. Therefore, present study, male C57BL6/JUnib mice (8 weeks old) were divided into control...
The renin-angiotensin system (RAS) is subject to sex-specific modulation by hormones and gene products. However, sex differences in the balance between vasoconstrictor/proliferative ACE/ANG II/AT1 axis, vasodilator/antiproliferative ACE2/ANG-(1-7)/MAS axis are poorly known. Data rat have suggested male-specific Y-chromosome Sry contribute these two axes, but why testis-determining has functions remains unknown. A combination of silico genetic/protein comparisons, functional luciferase assays...
Sepsis is an uncontrolled systemic inflammatory response against infection and a major public health issue worldwide. This condition affects several organs, and, when caused by Gram-negative bacteria, kidneys are particularly damaged. Due to the importance of renin-angiotensin system (RAS) in regulating renal function, present study, we aimed investigate effects endotoxemia over RAS. Wistar rats were injected with Escherichia coli lipopolysaccharide (LPS) (4 mg/kg), mimicking induced...
Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene ( ACE in humans, Ace mice). The aim was to evaluate modulation copies number diabetes mellitus (DM) on renal RAS correlate it with indicators kidney function. Increased gene, associated DM, induces dysfunction. susceptibility development DN 3 animals is imbalance activity enzymes leading increased synthesis Ang II Ang-(1–7)....
Increasing evidence shows the essential participation of gut microbiota in human health and diseases by shaping local systemic immunity. Despite an accumulating body studies showing that chronic kidney disease (CKD) is closely associated with disturbances composition microbiota, it remains unclear importance onset development CKD. For purpose untangling role CKD, was depleted a pool broad-spectrum antibiotics mice submitted to unilateral ureteral obstruction (UUO). Depletion significantly...
The testis determining protein, Sry, has functions outside of determination. Multiple Sry loci are found on the Y-chromosome. Proteins from these have differential activity promoters renin-angiotensin system genes, possibly contributing to elevation blood pressure. Variation at amino acid 76 accounts for majority effects by rat proteins Sry1 and Sry3. Human SRY regulated in same manner as elevating Agt, Ren , Ace promoter while downregulating 2 . significantly human AGT, REN, ACE2, AT2, MAS...
Abstract Previous studies have shown that the renin–angiotensin system (RAS) is affected by adverse maternal nutrition during pregnancy. The aim of this study was to investigate effects a low-protein diet on proinflammatory cytokines, reactive oxygen species and RAS components in kidney samples isolated from adult male offspring. We hypothesized post-weaning losartan treatment would beneficial activity inflammatory oxidative stress markers these animals. Pregnant Sprague–Dawley rats were fed...
The ACE2 (angiotensin-converting enzyme 2)/Ang-(1–7) [angiotensin-(1–7)]/MAS axis of the RAS (renin–angiotensin system) has emerged as a pathway interest in treating both cardiovascular disorders and cancer. MAS protein is known to bind be activated by Ang-(1–7); however, mechanisms this activation are just starting understood. Although there strong biochemical data regarding regulation AT1R (angiotensin II type 1 receptor) AT2R 2 receptor), with models how AngII II) binds each receptor,...
Background: Tonin, a serine-protease that forms Angiotensin II (AngII) from angiotensinogen, is increased in failing human heart samples. Increased blood pressure (BP) and decreased rate (HR) variabilities are associated with higher risk of cardiovascular morbidity. Losartan has been used to reduce hypertension and, therefore, lowers the fatal nonfatal events. Determination tonin's impact on BP HR as well losartan remain questions be elucidated. Aim: Evaluation autonomic profile transgenic...
Aims The objective of this study was to evaluate the expression bladder receptors in patients with defunctionalized (DB) and assess voiding behavior after refunctionalization. Methods A total 68 pretransplant were divided two groups: DB (diuresis <300 mL/24 h; n = 33) NDB (non‐DB; diuresis ≥300 35). sample mucosa detrusor at site future ureteral implantation collected. following assessed by real‐time polymerase chain reaction (qRT‐PCR): M 2 , 3 α 1D β P2X TRPV1, TRPV4, TRPA1, TRPM8. At 3,...
Introduction: Hypertension is nearly universal in kidney transplant and several factors are associated with post hypertension, including immunosuppressive medications genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) transplantation Wistar possible transference 80/90-kDa N-domain ACE. Methods: To do so, data from recipients SHR compared transplanted submitted CsA treatment and, Sham. Results Discussion: Despite unaltered blood...