A5009760924- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Retinoids in leukemia and cellular processes
- Lipid metabolism and biosynthesis
- Cancer-related Molecular Pathways
- Metal complexes synthesis and properties
- Copper-based nanomaterials and applications
- Iron oxide chemistry and applications
- Photoacoustic and Ultrasonic Imaging
- Polydiacetylene-based materials and applications
- Porphyrin and Phthalocyanine Chemistry
- Cannabis and Cannabinoid Research
- Advanced Nanomaterials in Catalysis
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Characterization and Applications of Magnetic Nanoparticles
- Biosensors and Analytical Detection
- Muscle Physiology and Disorders
- RNA modifications and cancer
- Genetic Neurodegenerative Diseases
Xiamen University
2011-2020
Wright State University
2018
Collaborative Innovation Center of Chemistry for Energy Materials
2017
Monodisperse Gd2O3-embedded iron oxide (GdIO) nanoparticles can simultaneously enhance the local magnetic field intensities of each other under an external and result in synergistic enhancement T1 T2 effects. GdIO have unique property to be both contrast agents potentially lead higher accuracy cancer diagnosis, particularly liver tumors.
Controlled synthesis of monodisperse iron oxide (IO) nanostructures with diverse morphology remains a major challenge. In this work, IO various shapes and surface structures were synthesized by thermal decomposition oleate (FeOL) in the presence sodium (NaOL). mild condition using 1-octadecene (ODE) as solvent, NaOL may preferentially bind to Fe3O4{111} facets lead formation facet exposed plates, truncated octahedrons, tetrahedrons. While high-boiling temperature tri-n-octylamine (TOA) we...
We described the smart and targeted magnetic nanocarriers to control delivery release of anticancer drug doxorubicin (DOX) in vitro demonstrated that they can exhibit much higher cytotoxicity cancer cells than free DOX. The conjugation magnetite nanoparticles (∼14 nm diameter) DOX molecule via acid-labile imine bond endows with three advanced features: magnetically controllable, specific targeting, pH-responsive. cell toxicity assays indicated pH-sensitive (IC50 0.13 μg mL−1 HeLa cells) have...
We combined silver and iron oxide nanoparticles to make unique Ag@Fe2O3 yolk–shell multifunctional by the Kirkendall effect. After surface functionalization using glucose, Ag@Fe2O3–Glu conjugates exhibited both high capture efficiency of bacteria potent antibacterial activity. The nanostructures may offer a platform for simultaneous rapid detection safe detoxification treatment.
Autophagy plays a key role in human health and disease, especially cancer neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms universal rules remain unclear. Here, first time, we show reliable general mechanism by which nanoparticles then successfully modulate via tuning their dispersity. Various well-designed univariate experiments demonstrate that dispersity-dependent...
Gold nanospheres stimulate more autophagosome accumulation than gold nanorods due to their higher efficiency of cellular uptake.
Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes dysfunction, whereas little is known how SiNPs trigger activation. Here, we treated normal rat kidney (NRK) cells using 3 different sizes (16, 29, and 51 nm) observed 16-nm SiNPs, with final concentration 60 μg/mL, dramatically induce activation without reducing cell...
Arsenic trioxide is a clinical drug that can be used to successfully treat acute promyelocytic leukemia. However, its therapeutic effect on solid tumors limited because of the poor pharmacokinetics and dose-limiting toxicity. Here, we report facile strategy achieve high anticancer activity arsenic by loading nanoparticulate prodrug into hollow silica inorganic nanoparticles. Because appropriate size, pH sensitivity, surface targeted modification, this smart nanosized system deliver cancer...
Multifunctional nanostructures combining diagnosis and therapy modalities into one entity have drawn much attention in the biomedical applications.Herein, we report a simple cost-effective method to synthesize novel cubic Au nano-aggregates structure with edge-length of 80 nm (Au-80 CNAs), which display strong near-infrared (NIR) absorption, excellent water-solubility, good photothermal stability, high biocompatibility.Under 808 laser irradiation for 5 min, temperature solution containing...
Abstract Hepatocellular carcinoma (HCC) is one of the highest incidences in cancers; however, traditional chemotherapy often suffers from low efficiency caused by drug resistance. Herein, we report an arsenite-loaded dual-drug (doxorubicin and arsenic trioxide, i . e ., DOX ATO) nanomedicine system (FeAsO x @SiO 2 -DOX, Combo NP) with significant synergy pH-triggered release for effective treatment resistant HCC cells (HuH-7/ADM). This nano-formulation NP exhibits synergistic effect DNA...
Autophagy of mitochondria (mitophagy) is essential for maintaining muscle mass and healthy skeletal muscle. Patients with heritable phosphatidic acid phosphatase lipin-1-null mutations present severe rhabdomyolysis atrophy in glycolytic fibers, which are accompanied mitochondrial aggregates reduced cytochrome c oxidase activity. However, the underlying mechanisms leading to as a result lipin-1 deficiency still not clear. In this study, we found that mice associated marked accumulation...
Well-dispersed gold nanoparticles show rather good biocompatibility, while aggregated with the same dose considerable cytotoxicity. This result indicates that dispersity of plays an important role in
Key points Lipin1 is critical for skeletal muscle development. regulates MyoD and myocyte‐specific enhancer factor 2C (MEF2c) expression via the protein kinase C (PKC)/histone deacetylase 5‐mediated pathway. Inhibition of PKCμ activity suppresses myoblast differentiation by inhibiting MEF2c expression. Abstract Our previous characterization global lipin1‐deficient ( fld ) mice demonstrated that lipin1 played a novel role in (SM) regeneration. The present study using cell type‐specific...
Silica sub-microparticles, 0.5–0.7 μm in diameter, induce high levels of autophagy due to their suitable size for endocytosis.