A5101478426- Inflammatory Bowel Disease
- Microscopic Colitis
- Head and Neck Cancer Studies
- Eosinophilic Esophagitis
- Intracranial Aneurysms: Treatment and Complications
- Gut microbiota and health
- Vascular Malformations Diagnosis and Treatment
- Diverticular Disease and Complications
- Meningioma and schwannoma management
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects of Natural Compounds
- X-ray Spectroscopy and Fluorescence Analysis
- Seismology and Earthquake Studies
- Pregnancy and Medication Impact
- Radioactivity and Radon Measurements
- Neurofibromatosis and Schwannoma Cases
- Additive Manufacturing Materials and Processes
- High Entropy Alloys Studies
- Advanced Radiotherapy Techniques
- Heavy Metal Exposure and Toxicity
- Ear and Head Tumors
- Earthquake Detection and Analysis
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2025
Sun Yat-sen University
2015-2025
Hunan First Normal University
2024
Southern Medical University Shenzhen Hospital
2024
Tianjin University of Sport
2024
Hunan Normal University
2024
East China Normal University
2023
Liaoning University of Technology
2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
Summary Background Thiopurine‐induced leukopenia is the most common dangerous adverse event in Asians. NUDT 15 R139C was recently proposed to be a promising biomarker for with thiopurine therapy Asians, but this has not been replicated Chinese population. Aim To investigate influence of R139C, S‐methyltransferase ( TPMT ), 6‐ TGN and MMPR on thiopurine‐induced patients Crohn's disease. Methods Clinical epidemiological characteristics were reviewed from medical records. genotyped. /6‐...
Abstract Background Ustekinumab (UST), a novel biological agent for Crohn’s disease (CD), has shown efficacy in CD patients. Our objective was to establish clinical prediction models accurately forecast the short- and long-term effectiveness of UST individuals diagnosed with CD. Methods We established derivation cohort comprising patients treated at Sixth Affiliated Hospital Sun Yat-sen University from May 2020 July 2023. The were assigned 7:3 ratio random training validation cohort....
Abstract Background Endoscopic balloon dilation (EBD) is a safe and effective procedure for treating stenosis in patients with Crohn's disease (CD). This study aimed to evaluate factors associated endoscopic restenosis after EBD construct prognostic model. Methods We retrospectively collected analyzed data on receiving treatment at the Sixth Affiliated Hospital of Sun Yat-sen University from 2013 2024. Seven machine learning (ML) algorithms were used And explore potential biomarkers...
Abstract Background This study aims to clarify the uncertain impact of Crohn’s disease on fertility among Chinese female by comparing their rates with those general population. Methods From January 2012 December 2022, patients at Sixth Affiliated Hospital Sun Yat-sen University were identified through hospital records. Female aged 15 44 included. Demographic and data collected structured questionnaires. Comparative for population obtained from National Bureau Statistics China. Age-adjusted...
Abstract Background High adalimumab dosing for Crohn's disease remains uncertain. This study evaluated the efficacy and safety of different doses in infliximab-naïve -exposed patients to guide individualized therapy. Methods A retrospective, multicenter cohort with propensity score weighting included Crohn’s treated at Sun Yat-sen University Sixth Affiliated Hospital from January 2019 July 2022. Clinical remission, objective response, sustained remission rates were assessed 12 52 weeks....
Abstract Background Ustekinumab (UST) is recommended as the first-line treatment for patients with moderate to severe Crohn's disease (CD). The effectiveness of certain patients, however, may be suboptimal and necessitate intensive or modification regimen. We sought establish a nomogram model predict short-term UST in CD patients. Methods established derivation cohort comprising diagnosed treated at Sixth Affiliated Hospital Sun Yat-sen University between May 2020 July 2023. patient data,...
Abstract Background Inflammatory bowel disease (IBD) requires effective treatment options. Upadacitinib, a Janus kinase 1 (JAK1) inhibitor, has shown effectiveness in trials for Crohn’s (CD) and ulcerative colitis (UC). This study evaluates its real-world safety. Methods We conducted multicenter retrospective cohort tertiary care centers, involving patients treated with upadacitinib from January 2023 to September 2024. The included adult aged 18 years or older, diagnosed UC CD, who received...
Abstract Background The gut microbiota plays a significant role in the development of inflammatory bowel disease (IBD). There is close interaction between oral and microbiota. However, "oral-gut" microbial axis IBD not yet clear. Methods 1. Analyzed oral-gut patterns 97 patients using 16S rDNA sequencing bioinformatics methods. 2. A mouse colitis model with DSS was used. It gavaged from CD to assess impacts on 3. Isolated specific differential bacteria, Veillonella, patient saliva evaluated...
Abstract Background The optimal treatment strategy for moderate-to-severe ulcerative colitis (UC) remains challenging. This study aimed to evaluate the efficacy and safety of combination therapy with vedolizumab (VDZ) plus upadacitinib (UPA) compared VDZ monotherapy. Methods In this multicenter, prospective, randomized controlled trial, patients UC were receive either (300mg at weeks 0, 2, 6, then every 8 through week 54) UPA (45mg daily weeks) or Primary endpoints included clinical...
In order to maximize the performance of nickel-based cladding layer without adding a reinforcing phase, ultrasonic vibrations different frequencies are assisted in laser process. The morphology was analyzed by metallographic microscope, microstructure SEM, element segregation EDS energy spectrum, and microhardness tested tester. Hardness friction-wear were using friction wear test results show that appropriate frequency can obviously refine layer, hardness resistance have been significantly...
<h3>Objective:</h3> To explore the value of neuroendoscopy in surgery for primary hemifacial spasm (HFS) patients with complicated local anatomy. <h3>Methods:</h3> Endoscopic-assisted microvascular decompression (MVD) was performed 42 HFS anatomy from January 2008 to 2012 our department, event a significant blind spot, endoscopic exploration multi-angle 360-degree observation, including brainstem facial nerve root exit zone (REZ) and distal end nerve, relationships between blood vessels...
Abstract Background The correlation between cirrhosis and the long‐term oncological outcome in intrahepatic cholangiocarcinoma (ICC) is debatable, this study aimed to explore impact of on prognosis patients with ICC. Methods A total 398 ICC were identified Surveillance, Epidemiology, End Results (SEER) database from 2000 2018. diagnosis was based Ishak fibrosis score provided by SEER database. Propensity matching (PSM) inverse probability treatment weighting (IPTW) analysis performed...
As a traditional method for the assessment of colon dynamics, radio-opaque markers (ROMs) are limited in clinical use because their ionizing radiation. We compared accuracy and applicability gadolinium-based capsules with ROMs measurement dynamics healthy controls slow transit constipation (STC) patients.Seven patients STC nine under normal diet orally consumed simultaneously. All subjects underwent X-ray magnetic resonance imaging (MRI). Healthy control images were acquired at 12, 24, 48 h,...
<title>Abstract</title> The aim of this study was to investigate the effects PAP induced by different squat amplitudes on jump and interaction between amplitude, stimulus load (%1RM) duration, establish an exercise intervention programme. Method: Fifteen track field athletes aged 20-22 years were selected perform barbell back squats at knee angles 60°, 90° 120° loads 75% 1RM, 85% 1RM 95% their flat heights tested 3rd, 6th, 9th 12th minute after each combination squats. Results: (1)...
Abstract Background The gut microbiome represents a promising avenue to elucidate distinct underlying pathophysiology in Crohn's disease (CD).Our aim was evaluate the composition of microbiota Inflammatory B1 and Stricturing B2 Phenotype. Methods We performed 16S ribosomal RNA sequencing on stool samples 108 patients (64 44 B2) included Chinese CD cohort 58 health controls without any inflammatory disorder, order explore structural different phenotype CD. Results Comparison between with...
Abstract Background The optimal regimen of infliximab salvage in acute severe ulcerative colitis (ASUC) patients remains controversial. This retrospective multicenter study aimed to compare accelerated and standard induction a Chinese cohort ASUC patients, explore risk factors associated with poor prognosis. Methods Data were collected retrospectively from steroid-refractory who received as rescue therapy at seven tertiary centers across China. Accelerated was defined receiving two doses on...
Abstract Background Previous studies have shown acute pancreatitis (AP) to be the most common pancreatic disease in inflammatory bowel (IBD) patients, with Crohn's (CD) patients exhibiting significantly higher incidence than ulcerative colitis (UC) patients. However, shared biological mechanisms remain elusive. This study aimed identify differentially expressed genes (DEGs) between CD and AP explore their associated molecular using bioinformatics approaches. Methods Microarray datasets...