A5062815482- Colorectal and Anal Carcinomas
- Hair Growth and Disorders
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Facial Rejuvenation and Surgery Techniques
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Dermatologic Treatments and Research
- Radiation Therapy and Dosimetry
- Cancer Treatment and Pharmacology
- Hematopoietic Stem Cell Transplantation
- Breast Implant and Reconstruction
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cancer therapeutics and mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Ethics in Clinical Research
- Head and Neck Cancer Studies
- Ion Transport and Channel Regulation
Genomics Institute of the Novartis Research Foundation
2009-2025
Brown University
2010-2023
AbbVie (Ireland)
2022
Allergan (Ireland)
2018-2022
Torrance Memorial Medical Center
2019-2021
Allergan (United States)
2019-2021
AbbVie (United States)
2021
Providence College
2012-2019
Lifespan
2015-2019
Sunset Laboratory (United States)
2019
Inhibition of airway epithelial sodium channel (ENaC) function enhances mucociliary clearance (MCC). ENaC is positively regulated by channel-activating proteases (CAPs), and CAP inhibitors are therefore predicted to be beneficial in diseases associated with impaired MCC. The aims the present study were 1) identify low-molecular-weight CAPs 2) establish whether such would translate into a negative regulation vivo, consequent enhancement To this end, camostat, trypsin-like protease inhibitor,...
The U.S. Food and Drug Administration has required postapproval studies of silicone breast implants to evaluate the incidence rare adverse events over 10 years after implantation.The Breast Implant Follow-Up Study is a large 10-year study (>1000 sites) evaluating long-term safety following primary augmentation, revision-augmentation, reconstruction, or revision-reconstruction with Natrelle round compared national norms outcomes saline implants. Targeted in subjects followed for 5 8 included...
VYC-25L, a hyaluronic acid soft-tissue filler with lidocaine, is designed to restore and create facial volume in the chin jaw.To evaluate safety effectiveness of VYC-25L subjects retrusion.Adults retrusion (145°-165° glabella-subnasale-pogonion angle) were randomized (3:1) receive chin/jaw at study onset (treatment group) or 3 months later (control group). Primary end point was mean change angle from baseline Month 3. Safety assessments included injection site responses (ISRs), recorded...
Abstract Background Juvéderm Volux (VYC-25L; Allergan plc) is an injectable hyaluronic acid gel designed to restore and create facial volume. Objective The aim of this study was evaluate the safety effectiveness for chin retrusion over 18 months after repeat treatment. Methods This prospective, single-blind, controlled enrolled subjects aged ≥18 years with (glabella-subnasale-pogonion angle 145°-165°). Subjects were randomized (3:1) at onset or 3 later (control group), could receive a single...
BACKGROUND VYC-20L is a hyaluronic acid soft tissue filler with lidocaine designed to restore facial volume. OBJECTIVE Evaluate the safety and effectiveness of in patients chin retrusion. MATERIALS AND METHODS Adults retrusion were randomized (3:1) receive at study onset (treatment group) or 6 months later (control group). The primary end point was ≥1-point improvement on Allergan Chin Retrusion Scale (ACRS) from baseline Month 6. Safety assessments included injection site responses (ISRs)...
Background Informed consent forms (ICFs) for oncology clinical trials have grown increasingly longer and more complex. We evaluated objective understanding of critical components informed among patients enrolling in contemporary conventional or novel biologic/targeted therapies. Methods ICFs cancer length readability, registered on those studies were asked to complete a validated 14-question survey assessing their key characteristics the trial. Mean scores compared groups defined by trial...
The incidence of early-onset colorectal cancer (eoCRC) diagnosed among individuals under age 50 has been rising. However, risk factors for eoCRC are unclear. We investigated whether metabolic abnormalities adenocarcinoma.Invasive adenocarcinoma cases between ages 15 and 49 from 2008 to 2018 at Kaiser Permanente Southern California (KPSC) were identified. Those with a history inflammatory bowel disease excluded. Noncancer controls selected 5:1 each case matched by age, sex, length membership...
Background: Few studies have assessed long-term complications in women undergoing implant-based breast reconstruction with use of an acellular dermal matrix (ADM). This study compared outcomes over 5 years procedures and without ADM. Methods: Complications data patients enrolled the prospective Continued Access Reconstruction/Revision Expansion trial were segregated by ADM versus no primary or revision-reconstruction. evaluated safety effectiveness shaped, textured, silicone implants....
To determine the overall survival for patients with metastatic pancreatic cancer treated lapatinib and gemcitabine. Patients received lapatinib, 1,500 mg/d, Gemcitabine, 1 g/m(2)/wk 3 weeks followed by week off, until disease progression. This multicenter phase II study was planned to enter 125 evaluate whether treatment regimen could achieve a 1-year of 30% median 7 months. An additional subset 20 were receive 2 months single agent At 6 month analysis, Brown University Oncology Group Data...
Abstract HOXB13 is a lineage-dependent transcription factor involved in the growth of androgen-independent prostate cancer cells. It promotes cell proliferation low-androgen environments by activating E2F signaling and inhibiting expression p21 tumor suppressor. Its restricted to largely absent from normal tissue making it an intriguing oncology target. Furthermore, reported that regulator androgen receptor (AR), ChIP-seq signature overlaps with those full-length AR splice variant lacking...
The epithelial-mesenchymal transition (EMT) is a complex change in cell differentiation that allows breast carcinoma cells to acquire invasive properties. EMT involves cascade of regulatory changes destabilize the epithelial phenotype and allow mesenchymal features manifest. As transcription factors (TFs) are upstream effectors genome-wide expression result phenotypic change, understanding sequential TF activity during provides rich information on mechanism this process. Because molecular...
VYC-15L (Juvéderm Volbella XC) is a nonanimal crosslinked hyaluronic acid (HA) gel with lidocaine. To evaluate safety and effectiveness of repeat treatment administered 1 year after for lip perioral enhancement. In this prospective multicenter study, 124 subjects minimal, mild, or moderate fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) who received initial/touch-up initial treatment. Effectiveness endpoints included LFS responder rates (≥1-point improvement from...
Inhaled amiloride, a blocker of the epithelial sodium channel (ENaC), enhances mucociliary clearance (MCC) in cystic fibrosis (CF) patients. However, dose amiloride is limited by mechanism-based side effect hyperkalaemia resulting from renal ENaC blockade. blockers with reduced potential to induce provide therapeutic strategy improve mucosal hydration and MCC lungs CF The present study describes preclinical profile novel blocker, NVP-QBE170, designed for inhaled delivery, hyperkalaemia.The...
Patients with cancer experience stress surrounding diagnosis and treatment. Many centers employ a nurse-led education session to alleviate patient anxiety confusion. .The goal was evaluate the effect of chemotherapy teaching on patients' knowledge, anxiety, preparedness for cancer-directed therapy. .After discussing treatment their oncologist, participants completed survey assessing perceived understanding various topics. After, they underwent an oncology nurse. The readministered when...
This study aims to report tumor control rates and cranial nerve function after low dose (11.0 Gy) Gamma knife radiosurgery (GKRS) in patients with vestibular schwannomas.A retrospective chart review was performed on 30 consecutive schwannomas treated from March 2004 August 2010 GKRS at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. The marginal for all 11.0 Gy prescribed 50% isodose line. Median follow-up time 42 months. median treatment volume 0.53 cm3. Hearing...
Abstract Background The updated AJCC Cancer Staging Manual groups all p16‐positive oropharyngeal squamous cell carcinoma (OPSCC) with unilateral nodal involvement within 6 cm into the new clinical N1 classification, consolidating a heterogeneous group of disease varying radiographic findings. Methods A central radiological review was conducted identifying 233 patients stage I node‐positive (cT1‐2N1) who underwent definitive concurrent chemoradiation. Factors evaluated included lymph node...
Abstract Background Women with breast implants may have concerns about their ability to successfully breast-feed. The Breast Implant Follow-up Study (BIFS-001) is a large, 10-year observational study evaluating the performance and safety of Natrelle round silicone gel-filled implants. Objectives This analysis compared lactation outcomes in women enrolled BIFS-001 who gave birth after they underwent primary augmentation or saline Methods At baseline annually surgery (>5-year visit window),...
Purpose: Successful clinical trial accrual targeting uncommon genomic alterations will require broad national participation from both National Cancer Institute (NCI)–designated comprehensive cancer centers and community programs. This report describes the initial experience with after next-generation sequencing (NGS) three affiliated non–NCI-designated Materials Methods: Clinical was reviewed enrollment of first 200 patients undergoing profiling by NGS as part an institutional intuitional...
Objectives: Src family kinases (SFKs) are expressed in NSCLC and may be involved tumor growth metastases. Inhibition of SFK also enhance radiation. The purpose this study was to evaluate if a maximum dose 100 mg dasatinib could safely administered with concurrent chemoradiation then continued as maintenance for patients newly diagnosed stage III NSCLC. Methods: Patients locally advanced received paclitaxel, 50mg/m2/week, carboplatin area under the curve (AUC) = 2, weekly 7 weeks,...
Radical prostatectomy (RP) with pelvic lymph node dissection (PLND) is the standard treatment of high-risk prostate cancer. High-risk patients and those metastasis (LNM) require further treatment. We review outcomes RP+PLND in Kaiser Permanente Southern California (KPSC).Patients who underwent KPSC from January 1, 2001, to July 2015 were included. Patient charts retrospectively reviewed for demographic information clinicopathologic data which used calculate positive surgical margin rate,...