A5101632369- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- RNA regulation and disease
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Heat shock proteins research
- RNA and protein synthesis mechanisms
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Cardiomyopathy and Myosin Studies
- Cancer-related gene regulation
- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- Advances in Cucurbitaceae Research
- Bioactive Compounds and Antitumor Agents
- Internet Traffic Analysis and Secure E-voting
- Biological Activity of Diterpenoids and Biflavonoids
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- Brain Metastases and Treatment
- Healthcare and Venom Research
Jinan University
2018-2025
Second Military Medical University
2014-2025
Changhai Hospital
2010-2025
First People's Hospital of Chongqing
2024-2025
Fudan University
2024-2025
Inner Mongolia University of Science and Technology
2025
Second Affiliated Hospital of Harbin Medical University
2013-2024
Harbin Medical University
2013-2024
Guangzhou University
2024
Key Laboratory of Guangdong Province
2022
Extensive pre-mRNA back-splicing generates numerous circular RNAs (circRNAs) in human transcriptome. However, the biological functions of these circRNAs remain largely unclear. Here we report that N6-methyladenosine (m6A), most abundant base modification RNA, promotes efficient initiation protein translation from cells. We discover consensus m6A motifs are enriched and a single site is sufficient to drive initiation. This m6A-driven requires factor eIF4G2 reader YTHDF3, enhanced by...
MicroRNAs are involved in several aspects of cardiac hypertrophy, including growth, conduction, and fibrosis. However, their effects on the regulation cardiomyocyte cytoskeleton this pathological process not known. Here, with microRNA microarray small RNA library sequencing, we show that microRNA-1 (miR-1) is most abundant human heart. By applying bioinformatic target prediction, a regulatory protein twinfilin-1 was identified as potential miR-1. Overexpression miR-1 only reduced luciferase...
Cardiac hypertrophy, which is characterized by an increase in cell size and reactivation of fetal genes, occurs as adaptive response to diverse forms stress often results heart failure sudden death. Growing evidence indicates that microRNAs (miRNAs) are involved cardiac but the function these miRNAs remains elusive. Here, using real time PCR analysis, we showed several were dynamically regulated rat hypertrophic hearts miR-199a was up-regulated 10-fold after abdominal aorta constriction for...
The outbreak of pneumonia caused by SARS-CoV-2 posed a great threat to global human health, which urgently requires us understand comprehensively the mechanism infection.Angiotensin-converting enzyme 2 (ACE2) was identified as functional receptor for SARS-CoV-2, distribution may indicate risk different organs vulnerable infection.Previous studies investigating ACE2 mRNA in tissues only involved limited size samples and lack determination protein.Given heterogeneity among humans, datasets...
Cardiac hypertrophy, which is characterized by the enlargement of cell size, reactivation fetal genes, remains one most important triggers to heart failure. Increasing evidence shows that microRNA (miRNA) extensively involved in pathogenesis cardiac hypertrophy. But effects miRNAs on cardiomyocyte hypertrophy have not been completely solved yet. Here, we showed a collection was aberrantly expressed hypertrophic cardiomyocytes induced phenylephrine (PE) or angiotensin II (Ang II). Among them,...
Infection of Herpes simplex virus 1 (HSV-1) induces severe clinical disorders, such as herpes encephalitis and keratitis. Acyclovir (ACV) is the current therapeutic drug against viral infection ACV-resistant strains have gradually emerged, leading to requirement for novel antiviral agents. In this study, we exhibited activity amentoflavone, a naturally occurring biflavonoid, toward HSV-1 strains. Amentoflavone significantly inhibited (F strain), well several including HSV-1/106, HSV-1/153...
Herpes simplex encephalitis (HSE), a complication of herpes virus type I (HSV-1) infection causes neurological disorder or even death in immunocompromised adults and newborns. However, the intrinsic factors controlling HSE outcome remain unclear. Here, we show that mice exhibit gut microbiota dysbiosis altered metabolite configuration tryptophan-nicotinamide metabolism. HSV-1 neurotropic activated microglia, with changed immune properties cell numbers, to stimulate antiviral response...
This study aimed to evaluate the efficacy and safety of intrathecal pemetrexed (IP) for treating patients with leptomeningeal metastases (LM) from non-small-cell lung cancer (NSCLC) who progressed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment in an expanded, prospective, single-arm, phase II clinical (ChiCTR1800016615).
Herpes simplex virus (HSV) type 1 (HSV-1) infection exhibited high heterogeneity at individual cells level, including the different gene expression patterns and varying amounts of progeny virus.However, underlying mechanism such variability remains obscure.The importance host long noncoding RNAs (lncRNAs) in had been recognized, while contribution lncRNAs to heterogeneous unknown.Herein, a prior single-cell RNA sequencing data using HSV-1 reporter strain expressing ICP4-YFP was re-analyzed...
Abstract Background Herpes simplex virus 1, an enveloped DNA belonging to the Herpesviridae family, spreads neurons and causes pathological changes in central nervous system. The purpose of this study was investigate potency mechanism antiviral activity Aspergillipeptide D, a cyclic pentapeptide isolated from culture broth marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501 , At present, there are many studies on anti-tumor, anti-clotting, anti-oxidant immunoinflammatory effects but...
Abstract Background N 7 -methylguanosine (m G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment heart failure (HF). Results One hundred twenty-four HF patients 135 nonfailing donors (NFDs) from six microarray datasets the gene omnibus (GEO) database were included evaluate profiles of m G regulators. revealed that 14 regulators differentially expressed...
To explore the mechanism of Circ-MYOCD back-splicing and its regulatory role in myocardial hypertrophy. Sanger sequencing RNase R assays were performed to verify circularity stability Circ-MYOCD, whose subcellular distribution was determined by nuclear-cytoplasmic fractionation. Bioinformatics analysis mass spectrometry from pull-down conducted predict RNA-binding proteins (RBPs) interacting with Circ-MYOCD. In rat cardiomyocytes H9C2 cells, effects HNRNPH1 HNRNPL knockdown overexpression on...
Although blood pressure can be regulated to normal levels through drug intervention, the prognosis for patients remains bleak, and there is an urgent need find a new way prevent or reverse hypertension its adverse consequences. Some studies have shown that effectively improved by exercise training, but exact manner in which it works not completely comprehended. Using spontaneously hypertensive rats (SHR) Wistar-Kyoto as models, 8-week intervention was adopted detect pressure, heart rate...
The stability of thermal barrier coating (TBC) materials during service is a prerequisite for the normal operation aircraft engines. high-temperature corrosion CaO–MgO–Al2O3–SiO2 (CMAS) an important factor that affects TBCs on turbine blades and causes premature engine failure. For traditional 6-8 YSZ, at temperatures more than 1200 °C, insulation performance significantly reduced, which makes it necessary to find new, alternative materials. La2Zr2O7 has good physical properties; addition...