A5025817625- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Forensic Toxicology and Drug Analysis
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Bee Products Chemical Analysis
- Drug-Induced Hepatotoxicity and Protection
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Proteins in Food Systems
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Toxin Mechanisms and Immunotoxins
- Pickering emulsions and particle stabilization
- Phytochemistry and biological activity of medicinal plants
- Ginkgo biloba and Cashew Applications
- Mesoporous Materials and Catalysis
- Fungal Biology and Applications
- Neurological Disease Mechanisms and Treatments
- Wound Healing and Treatments
Jiangxi University of Traditional Chinese Medicine
2013-2024
Air Force General Hospital PLA
2015-2023
Air Force Medical University
2023
Institute of Forensic Science
2010-2021
302 Military Hospital of China
2013-2016
PLA 306 Hospital
2013-2015
Institute of Chinese Materia Medica
2013-2015
Bioimaging of integral nanocrystals was achieved by embedded ACQ fluorophores, while absorption from GIT proved.
In this study, self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin (QT-HNCs) with diameter around 280 nm (QT-HNCs-280) and 550 (QT-HNCs-550) following oral intravenous administration contribution integral bioavailability enhancement QT estimated by comparing absolute exposure QT-HNCs total in liver. Results showed that could reside vivo as intact for long 48 h administration. A higher accumulation liver lung observed both QT-HNCs. The particle...
Paeoniflorin (Pae), a water-soluble monoterpene glucoside, has high potential clinical value in autoimmune and inflammatory diseases. However, the extremely low oral bioavailability of Pae (approximately 3%-4%) limits its formulation development application. This study aimed to develop micelles using glycyrrhizic acid (GL) as carrier improve absorption Pae.Pae-loaded GL were prepared by ultrasonic dispersion method was optimized single-factor tests. Characterizations Pae-loaded including...
Objective: The purpose of this study was to formulate stable Ganoderma lucidum (GLT) nanogels suitable for topical delivery with a view improve the therapeutic effect frostbite.Methods: GLT nanosuspensions were formulated using high-pressure homogenization technique and then suitably gelled characterized. In order confirm advantages nanogel dermal application, skin permeation studies in vitro pharmacodynamic evaluation vivo studied compared GLT–carbopol gel.Results: particle size analysis...
Background: Glycyrrhizic acid (GL), a pentacyclic triterpenoid glycoside, has been used as hepatoprotective agent for the treatment of acute and chronic hepatitis. However, its poor solubility permeability across gastrointestinal mucosa limit clinical efficacy. This study aimed to develop mixed micelles based on pluronic F127 d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) improve oral bioavailability GL.Methods: GL loaded F127/TPGS (GL-F127/TPGS-MMs) were prepared by thin film...
Cucurbitacin B (Cu B), a potent anti-cancer agent, suffers with the problems of water-insoluble, gastrointestinal side effects and non-specific toxicity via oral administration drawbacks in patient's compliance acceptance through injections. An integration nanoscale carriers mucoadhesive buccal films drug delivery system would resolve these issues effectively greater therapeutic benefits clinical significance. Thus, loaded film was developed characterized this study carboxymethyl chitosan...
Objective: The purpose of this study was to design and optimize a novel drug nanoparticles-loaded oral fast dissolving film (NP-OFDF) using Box–Behnken design–response surface methodology.Methods: Drug nanosuspensions produced from high pressure homogenization were transformed into containing nanoparticles by casting methods. Herpetrione (HPE), potent antiviral agent with poor water solubility that extracted Herpetospermum caudigerum, studied as the model drug. formulations HPE (HPE-NP-OFDF)...
The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability quercetin (QT). Quercetin nanocrystal (QT-NC) fabricated by high pressure homogenization method, and QT-NSSPE then prepared ultrasound method with QT-NC as solid particle stabilizer optimized Box-Behnken design. characterized fluorescence microscope (FM), scanning electron micrograph (SEM), X-ray diffraction (XRD), differential calorimetry (DSC)....
The purpose of this study was to design novel drug nanocrystals (NCs) stabilized by glycyrrhizic acid (GL) for achieving liver targeted delivery due the presence GL receptor in hepatocytes. Quercetin (QT) exhibits good pharmacological activities treatment diseases, including steatosis, fatty hepatitis, fibrosis, and cancer. It selected as a model owing its poor water solubility. QT NCs (QT-NCs/GL) were fabricated wet media milling technique systemically evaluated. QT-NCs poloxamer 188...
The aim of this study was to develop hyperoside (Hyp) nanocrystals enhance its dissolution rate, oral bioavailability and anti-HBV activity. Hyp were prepared using high pressure homogenization technique followed by lyophilization. A Box–Behnken design approach employed for process optimization. physicochemical properties, pharmacokinetics activity in vivo nanocrystal with the optimized formulation systematically investigated. found be rod shaped particle size 384 ± 21 nm PDI 0.172 0.027....
Multiple gastrointestinal barriers (mucus clearance and epithelium barrier) are the main challenges in oral administration of nanocarriers. To achieve efficient mucus penetration epithelial absorption, a novel strategy based on mesoporous silica nanoparticles with dendritic superstructure, hydrophilicity, nearly neutral-charged modification was designed. The mPEG covalently grafted (mPEG-DMSNs) had particle size about 200 nm loading capacity up to 50% andrographolide (AG) as nanocrystal...
Introduction. Trichophyton rubrum is a major causative agent of superficial dermatomycoses such as onychomycosis and tinea pedis. Huangqin decoction (HQD), classical traditional Chinese medicine formula, was found to inhibit the growth common clinical dermatophytes T. in our previous drug susceptibility experiments. Hypothesis/Gap Statement. The antifungal activity potential mechanism HQD against have not yet been investigated. Aim. aim this study investigate explore action . Methodology....
The purpose of this study was to investigate the impact different functional stabilizers on
In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for treatment infected wound. Hydrogel-grafted fabric prepared by graft copolymerization N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine embedded in to achieve sustained drug release. The characterized FT-IR spectroscopy, scanning electron microscopy, swelling degree studies. Fourier transform infrared spectroscopy revealed that into matrix...