A5004731198- Nanoplatforms for cancer theranostics
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Virology and Viral Diseases
- Protein purification and stability
- Click Chemistry and Applications
- Food Allergy and Anaphylaxis Research
- Glaucoma and retinal disorders
- Ocular Oncology and Treatments
- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
- Plant Pathogenic Bacteria Studies
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Head and Neck Cancer Studies
- Insect Utilization and Effects
Peking University
2024
Kunming Medical University
2018-2024
Peking University Cancer Hospital
2024
Novartis (China)
2023
China Medical University
2022
Nanchang University
2022
China Medical University
2022
China Medical University Hospital
2022
Jiangsu University
2020
Affiliated Hospital of Jiangsu University
2020
WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays critical role in multiple processes. It also prominent target for pharmacological inhibition diseases such as cancer, aging, and neurodegenerative disorders. Interactions between WDR5 various partners are essential sustaining its function. Most drug discovery efforts center on WIN (WDR5 interaction motif) site responsible recruitment to chromatin. Here, we describe novel inhibitors other WBM binding pocket...
Background: As key molecules that drive progression and chemoresistance in gastrointestinal cancers, epidermal growth factor receptor (EGFR) human 2 (Her2) have become efficacious drug targets this setting. But
WDR5 is a critical chromatin cofactor of MYC. interacts with MYC through the WBM pocket and hypothesized to anchor its WIN site. Blocking interaction impairs recruitment target genes disrupts oncogenic function in cancer development, thus providing promising strategy for treatment MYC-dysregulated cancers. Here, we describe discovery novel antagonists containing 1-phenyl dihydropyridazinone 3-carboxamide core that was identified from high-throughput screening subsequent structure-based...
AIM:To evaluate the effect of mitochondrial tumor necrosis factor receptor-associated protein-1 (TRAP-1) on lymph node metastasis (LNM) in Chinese colorectal cancer (CRC) patients, and develop potential LNMassociated biomarkers for CRC using quantitative realtime polymerase chain reaction (RT-PCR) analysis. METHODS:Differences TRAP-1 gene expression between primary with LNM (LNM CRC) without (non-LNM were assessed 96 carcinoma samples RT-PCR analysis, Western blotting, confirmed...
Background There is a close relationship between radiotherapy and autophagy in tumors, but the prognostic role of radiotherapy-related genes (RRAGs) lung adenocarcinoma (LUAD) remains unclear. Methods Data used current study were extracted from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Weighted gene co-expression network analysis (WGCNA) was executed to recognize module associated with radiotherapy. differentially expressed (DEGs) different response groups...
Silkworm pupa is a nourishing food with high nutritional value, but its consumption has been greatly limited given allergenicity. Enzyme hydrolytic technique recognized as an effective method to reduce the allergenicity of protein. In this study, we aimed investigate effect enzymolysis on silkworm pupa. Crude protein was extracted through alkali extraction and acid precipitation, which included 5 proteins molecular weights ranging from 34 kDa 76 kDa, were then hydrolyzed by alkaline...
Self-assembled prodrugs (SAPDs), which combine prodrug strategy and the merits of self-assembly, not only represent an appealing type therapeutics, enabling spontaneous organization supramolecular nanocomposites with defined structures in aqueous environments, but also provide a new method to formulate existing drugs for more favorable outcomes. To increase drug loading combination therapy, we covalently conjugated paclitaxel (PTX) camptothecin (CPT) through disulfide linker into prodrug,...
Double-strand DNA breaks (DSBs) are a key factor in carcinogenesis. The necessary repair of DSBs is pivotal maintaining normal cell division. To address the relationship between altered expression DSB proteins Ku70 and ataxia-telangiectasia mutated (ATM) colorectal cancer (CRC), we examined levels patterns ATM CRC samples.Expression coexpression were investigated by using real-time quantitative polymerase chain reaction assays confirmed further with fluorescent immunohistochemistry...
Abstract Purpose The aim of this study was to characterize changes in hippocampal inflammasomes, pyroptosis and apoptosis juvenile rats after brain irradiation assess whether manganese-enhanced magnetic resonance imaging (MEMRI) reflected those changes. Materials methods Four-week-old male Sprague-Dawley received a whole-brain radiation dose 15 Gy or 25 Gy. Hippocampal inflammasomes were measured using Western blot analysis at 4 days 8 weeks irradiation. MEMRI spectroscopy (MRS) performed...
Increasing evidence has implicated the modification of 7-methylguanosine (m 7 G), a type RNA modification, in tumor progression. However, no comprehensive analysis to date summarized predicted role m G-related gene signatures lung adenocarcinoma (LUAD). Herein, we aimed develop novel prognostic model LUAD based on signatures. The transcriptome profiling data and corresponding clinical were acquired from Cancer Genome Atlas (TCGA) two Gene Expression Omnibus datasets. After screening, first...
Abstract Sweetpotato [ Ipomoea batatas (L.) Lam.] is one of the most important crops in many developing countries and provides a candidate source bioenergy. However, neither high-quality reference genome nor large-scale full-length cDNA sequences for this outcrossing hexaploid are still lacking, which turn impedes progress research studies sweetpotato functional genomics molecular breeding. In study, we apply combination second- third-generation sequencing technologies to sequence...
Benzimidazoles have attracted much attention over the last few decades due to their broad-spectrum pharmacological properties. Increasing evidence is showing potential use of benzimidazoles as anti-angiogenic agents, although mechanisms that impact angiogenesis remain be fully defined. In this study, we aim investigate MFB, a novel 2-aminobenzimidazole derivative, develop inhibitor.MTT, BrdU, migration and invasion assays, immunoblotting were employed examine MFB's effects on vascular...
Tumor radiotherapy combined with immunotherapy for solid tumors has been proposed, but tumor vascular structure abnormalities and immune microenvironment often affect the therapeutic effect of tumor, multimodal imaging technology can provide more accurate comprehensive information in research. The purpose this study was to evaluate dynamic monitoring blood vessels induced by magnetic resonance/photoacoustic (MR/PA) imaging, explore its application value immunotherapy.The tumor-bearing mice...
The purpose of the present study was to evaluate feasibility using 4-dimensional computed tomography (4DCT)-ventilation-weighted dose analysis predict radiation-induced pneumonia probability (RIPP).The population for this retrospective included 16 patients with stage III lung cancer. Each patient's 4DCT images, including end-inhale and end-exhale sequences, were used deformable image registration, Hounsfield units (HU) density-change calculate ventilation. A previously established equation...
Abstract Background: We aim to investigate the expression of peptidylprolyl isomerase A (PPIA) gene in lung adenocarcinoma(LUAD),and diagnostic, prognostic value and correlation with immune infiltrates PPIA LUAD. Methods: Transcriptional profiles between LUAD tissues normal were downloaded from Cancer Genome Atlas (TCGA).The protein was assessed by Clinical Proteomic Tumor Analysis Consortium (CPTAC) .Receiver operating characteristic(ROC) curve used differentiate adjacent...
Abstract Backgroud: Tumor radiotherapy combined with immunotherapy for solid tumors has been proposed, but tumor vascular structure abnormalities and immune microenvironment often affect the therapeutic effect of tumor, there are few reports on multimodal imaging markers in study response. The purpose this was to evaluate dynamic monitoring blood vessels induced by magnetic resonance /photoacoustic (MR/PA) imaging, explore PD-L1 immunocheckpoint inhibitor. Methods tumor-bearing mice (TBM)...