A5017107823- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Genetic and Kidney Cyst Diseases
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
Rockefeller University
2023-2025
University of California, Berkeley
2022-2024
Howard Hughes Medical Institute
2022-2024
Stanford University
2023
Glia assess axon structure to modulate myelination and repair. Whether glia similarly detect dendrites their substructures is not well understood. Here we show that monitor the integrity of dendrite transiently protect them against perturbations. We demonstrate disruption C. elegans sensory neuron cilia elicits acute glial responses, including increased accumulation glia-derived extracellular matrix around cilia, changes in gene expression, alteration secreted protein repertoire. DGS-1, a...
Aging induces region-specific functional decline across the brain. The cerebellum, critical for motor coordination and cognitive function, undergoes significant structural changes with age. molecular mechanisms driving cerebellar aging, particularly role of glia, including microglia, remain poorly understood. Here, we used single-nuclei RNA sequencing (snRNA-seq), microglial bulk RNA-seq, multiplexed error-robust fluorescence in situ hybridization (MERFISH) to characterize transcriptional...
Highlights•Glial XBP-1s reduces peripheral lipids, boosts autophagy, and changes ER structure•Glial regulates the activation of HLH-30 in intestine•Lipid depletion lifespan extension phenotypes are dependent on hlh-30•Macroautophagy genes required for longevity altered structureSummaryGlia protectors nervous system, providing neurons with support protection from cytotoxic insults. We previously discovered that four astrocyte-like glia can regulate organismal proteostasis C. elegans....
Rates of cognitive decline in Alzheimers disease (AD) are extremely heterogeneous, with ages symptom onset ranging from age 40 to 100 years and conversion mild impairment AD dementia taking 2 20 years. Development biomarkers for amyloid-beta (AB) tau protein aggregates, the hallmark pathologies AD, have improved patient monitoring/stratification drug development, but they still only explain 40% variance (CI) AD. To discover additional molecular drivers dementia, we perform cerebrospinal...
SUMMARY Glia are the protectors of nervous system, providing neurons with support and protection from cytotoxic insults. We previously discovered that four astrocyte-like glia can regulate organismal proteostasis longevity in C. elegans . Expression UPR ER transcription factor, XBP-1s, these increases stress resistance, longevity, activates intestinal cells via neuropeptides. Autophagy, a key regulator metabolism aging, has been described as cell autonomous process. Surprisingly, we find...
Neurons have elaborate structures that determine their connectivity and functions. Changes in neuronal structure accompany learning memory formation are hallmarks of neurological disease. Here we show glia monitor dendrite respond to perturbation. In