A5100674290- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Gastric Cancer Management and Outcomes
- Inflammatory mediators and NSAID effects
- Helicobacter pylori-related gastroenterology studies
- Glutathione Transferases and Polymorphisms
- Ginger and Zingiberaceae research
- IL-33, ST2, and ILC Pathways
- Mitochondrial Function and Pathology
- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Lung Cancer Treatments and Mutations
- Fibroblast Growth Factor Research
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Metabolism and Genetic Disorders
- Digestive system and related health
- Head and Neck Cancer Studies
Coriell Institute For Medical Research
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2025
Cooper University Hospital
2023-2024
Cooper Medical School of Rowan University
2023-2024
Southern Medical University
2021-2024
Nanfang Hospital
2023-2024
Institute for Medical Research
2024
Cooper University Health Care
2023-2024
South China Normal University
2024
Tea is one of the most popular beverages consumed in world. Curcumin, major yellow pigment turmeric, used widely as a spice and food-coloring agent. In this study, we studied effects tea curcumin on 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis hamsters. DMBA solution (0.5% mineral oil, 0.1 ml) was applied topically to left cheek pouch male Syrian golden hamsters 3 times/week for 6 weeks. Two days after last treatment DMBA, animals received green (6 mg solids/ml) drinking...
Novel selective histone deacetylase 6 (HDAC6) inhibitors using the quinazoline as cap were designed, synthesized, and evaluated for HDAC enzymatic assays. N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide, 23bb, was most potent inhibitor HDAC6 with an IC50 of 17 nM showed 25-fold 200-fold selectivity relative to HDAC1 HDAC8, respectively. In vitro, 23bb presented low nanomolar antiproliferative effects against panel cancer cell lines. Western blot analysis...
In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical carcinogen treatment leads to gastroesophageal reflux disease, multilayered epithelium (MLE, a presumed precursor in intestinal metaplasia), columnar-lined esophagus, dysplasia, and esophageal adenocarcinoma. Previously we have shown that esophagus EGDA rats resembled human Barrett's (BE) its morphology, mucin features expression of differentiation markers (Lab. Invest. 2004;84:753-765). The purpose this study...
Mast cells may contribute to the pathogenesis of eosinophilic esophagitis (EoE), but their role in diagnosis is unknown. Our aim was determine whether tryptase staining esophageal mast differentiates EoE from gastroesophageal reflux disease (GERD) and has utility for EoE.We performed a case-control study comparing patients with EoE, defined by consensus guidelines, GERD eosinophils on biopsy. Immunohistochemistry cell tryptase. The density (mast cells/mm2) intensity (0-4 scale) compared...
Radiofrequency ablation (RFA) of Barrett's esophagus (BE) is safe and effective in eradicating dysplasia intestinal metaplasia, may reduce rates esophageal adenocarcinoma (EAC). We assessed risk factors for disease recurrence after successful treatment BE with RFA.We performed a retrospective cohort study patients who completed RFA dysplastic or intramucosal carcinoma (IMC), achieved complete eradication (CE-D) metaplasia (CE-IM), underwent subsequent endoscopic surveillance at single...
OBJECTIVES: Features of eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) overlap. We aimed to determine whether staining for tissue biomarkers would differentiate EoE from GERD, suggesting utility diagnosis EoE. METHODS: In this case–control study, patients defined by consensus guidelines were compared GERD with eosinophils on esophageal biopsy. Immunohistochemistry was performed major basic protein (MBP), eotaxin-3, leukotriene A4 hydrolase (LTA4H), C4 synthase...
As a major cellular defence mechanism, the Nrf2/Keap1 pathway regulates expression of genes involved in detoxification and stress response. Here we hypothesise that Nrf2 is oesophageal barrier function plays protective role against gastro-oesophageal reflux disease (GERD).Human biopsy samples, mouse surgical models Nrf2(-/-) mice were used to assess function. Trans-epithelial electrical resistance (TEER) was measured with mini-Ussing chambers. HE staining transmission electron microscopy...
Ginger has received extensive attention because of its antioxidant, anti-inflammatory, and antitumor activities. However, the metabolic fate major components is still unclear. In present study, metabolism [6]-shogaol, one active in ginger, was examined for first time mice cancer cells. Thirteen metabolites were detected identified, seven which purified from fecal samples collected [6]-shogaol-treated mice. Their structures elucidated as 1-(4'-hydroxy-3'-methoxyphenyl)-4-decen-3-ol (M6),...
Condensed tannins from Ficus virens leaves, fruit, and stem bark were isolated their structures characterized by 13C nuclear magnetic resonance spectrometry, high performance liquid chromatography electrospray ionization mass matrix-assisted laser desorption/ionization time-of-flight spectrometry. The results showed that the condensed complex mixtures of homo- heteropolymers B-type procyanidins prodelphinidins with degrees polymerization up to hexamer, dodecamer, pentadecamer, respectively....
The inhibition of punicalagin on tyrosinase and melanogenesis was investigated through multiple spectroscopic approaches, molecular docking, dynamic simulation, cell assay, preservation assays. results confirmed that significantly inhibited activity in vitro (IC50 = 0.64 ± 0.05 mM) B16F10 cells 16 0.7 μM). binding to changed the conformation enzyme by influencing hydrophobicity polar environment site. docking thermodynamic analysis showed hydrophobic interaction hydrogen bond were major...
In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), bioactive compound isolated from ginger, in colon epithelial cells vitro and vivo. Following 6S treatment HCT-116 cells, the intracellular GSH/GSSG ratio was initially diminished but then elevated above basal level. Intracellular reactive oxygen species (ROS) correlated inversely with ratio. Further analysis using gene microarray showed that upregulated expression genes (AKR1B10, FTL, GGTLA4, HMOX1) cells. Western...
// Aixian Lan 1, * , Wenjun Li Yao Liu 1 Zhaohui Xiong 2 Xinyan Zhang Shanshan Zhou 3 Olesya Palko Hao Chen Mayanga Kapita Justin R. Prigge 4 Edward E. Schmidt Xin Zheng Sun Xiaoxin Luke Department of Oral Medicine, Beijing Stomatological Hospital & School Stomatology, Capital Medical University, 100050, China Cancer Research Program, JLC-BBRI, North Carolina Central Durham, NC 27707, USA Pharmaceutical Engineering, Life Sciences, Changzhou Jiangsu 213164, Immunology and Infectious Diseases,...
Abstract Propionic acidemia (PA), resulting from Pcca or Pccb gene mutations, impairs propionyl-CoA metabolism and induces metabolic alterations. While speculation exists that fasting might exacerbate crises in PA patients by accelerating the breakdown of odd-chain fatty acids amino into propionyl-CoA, direct evidence is lacking. Our investigation effects -/- (A138T) mice, a model, reveals surprising outcomes. Propionylcarnitine, biomarker, decreases during fasting, along with C3/C2...