A5062716517- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Atomic and Subatomic Physics Research
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Sinusitis and nasal conditions
- Colorectal and Anal Carcinomas
- RNA regulation and disease
- Meningioma and schwannoma management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Research and Splicing
- Nasolacrimal Duct Obstruction Treatments
- Metastasis and carcinoma case studies
- Cancer and Skin Lesions
- Cancer-related molecular mechanisms research
Seoul National University Bundang Hospital
2017-2025
Seoul National University
2020-2023
Abstract We present an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs 27 individual donors. Our large-scale profiling identified new cell states differentiation trajectories rare epithelial types distal lungs. By integrating datasets lung tissues, we discovered immune-primed subsets enriched organoids patients with chronic respiratory disease. To demonstrate the full potential our platform, further...
SUMMARY The abnormal innate immune response is a prominent feature underlying autoimmune diseases. One emerging factor that can trigger dysregulated activation cytosolic mitochondrial double-stranded RNAs (mt-dsRNAs). However, the mechanism by which mt-dsRNAs stimulate responses remains poorly understood. Here, we discover SRA stem-loop interacting RNA binding protein (SLIRP) as key amplifier of mt-dsRNA-triggered antiviral signals. In diseases, SLIRP commonly upregulated, and targeted...
Many studies support a stepwise continuum of morphologic changes between atypical adenomatous hyperplasia (AAH) and lung adenocarcinoma (ADC). Here we characterized gene expression patterns the association differentially expressed genes immune tumor microenvironment behaviors in AAH to ADC during development. Tumor tissues from nine patients with synchronous multiple ground glass nodules/lesions (GGN/Ls) were analyzed using RNA sequencing. Using clustering, identified sequentially compared...
Activating mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) are predictive biomarkers for response to EGFR-tyrosine inhibitor (TKI) therapy lung adenocarcinoma (LUAD). Here, we characterized clinicopathologic features associated with EGFR via peptide nucleic acid clamping-assisted fluorescence melting curve analysis (PANAMutyper) and evaluated feasibility targeted deep sequencing detecting mutations. We examined exons 18 through 21 2,088 LUADs from July 2017...
Several criteria exist for classifying chronic rhinosinusitis with nasal polyps (CRSwNP) as eosinophilic or non-eosinophilic. This study attempted to evaluate several defining CRSwNP from clinical and immunological perspectives.A cohort of 84 patients (73 11 control patients) was retrospectively analyzed. Patients were divided into non-eosinophilic based on four different criteria: eosinophils (EOS) accounting more than 20% the total inflammatory cells; ≥70 EOS per high-power field (HPF);...
Both human leukocyte antigen (HLA) class I and programmed death-ligand 1 (PD-L1) molecules are known to play important roles in cancer immunity. In this study, we evaluated HLA expression resected adenocarcinoma of the lung, investigated its prognostic impact correlation with PD-L1 expression.HLA was by immunohistochemistry a total 403 lung adenocarcinomas using tissue microarray. Correlations between I/PD-L1 clinicopathologic features significance were analyzed.HLA reduced 91.6%...
Bruton's tyrosine kinase (BTK)-mediated B-cell-receptor signaling drives lymphomagenesis of diffuse large B-cell lymphoma (DLBCL). We investigated the clinicopathological significance BTK positivity in DLBCL according to known molecules related resistance inhibitors [BCL2 apoptosis regulator (BCL2)/MYC proto-oncogene, bHLH transcription factor (MYC)].We evaluated expression immunohistochemically 106 DLBCLs considering their BCL2/MYC status.Considering whole cohort, was expressed 65.1%,...
Despite advances in treatment, lung cancer remains the leading cause of mortality. This study aimed to characterise genome-wide tumorigenesis events and understand hypothesis multistep carcinogenesis adenocarcinoma (LUAD).We conducted multiregion whole-exome sequencing LUAD with synchronous atypical adenomatous hyperplasia (AAH), situ, or minimally invasive 19 samples from three patients characterize validate LUAD. We identified potential pathogenic mutations preserved preinvasive lesions...
Pulmonary sarcomatoid carcinoma (PSC) is a rare aggressive subtype of non-small cell lung cancer (NSCLC) with limited therapeutic strategies. We attempted to elucidate the evolutionary trajectories PSC using multiregional and longitudinal tumor samples.
Abstract We present an in-depth single cell atlas of in vitro multi-culture systems on human primary airway epithelium derived from normal and diseased lungs 27 individual donors. Our large-scale profiling identifies new states differentiation trajectories rare epithelial types distal lungs. By integrating datasets lung tissues, we discover immune primed subsets enriched organoids patients with chronic respiratory disease. To demonstrate the full potential our platform, further illustrate...