A5002955368- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Vascular Anomalies and Treatments
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
- Diagnosis and treatment of tuberculosis
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Nosocomial Infections in ICU
- Ultrasound in Clinical Applications
- Radiation Dose and Imaging
- Pulmonary Hypertension Research and Treatments
- Infectious Diseases and Tuberculosis
- Sarcoidosis and Beryllium Toxicity Research
- Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Mechanical Circulatory Support Devices
- Eosinophilic Disorders and Syndromes
Yonsei University
2014-2023
Wonju Severance Christian Hospital
2006-2018
Konkuk University
1995-1996
Abstract Background Oral CXC chemokine receptor 2 (CXCR2) antagonists have been shown to inhibit neutrophil migration and activation in the lung preclinical human models of neutrophilic airway inflammation. A previous study with danirixin, a reversible CXCR2 antagonist, demonstrated trend for improved respiratory symptoms health status patients COPD. Methods This 26-week, randomised, double-blind, placebo-controlled phase IIb enrolled symptomatic mild-to-moderate COPD at risk exacerbations....
Abstract Introduction The studies on hemoptysis have focused mainly causes and massive or life‐threatening hemoptysis. And there is a limited data that non‐massive hemoptysis, especially moderate Objectives We analyzed the prognosis severity of bleeding flexible bronchoscopy ( FB ) between Methods reviewed total 852 subjects (59.9 ± 16.0 years) identified with Reviewed database included subjective , comorbid conditions, time from admission to bronchial artery embolization BAE ), recurrent...
Adenosine deaminase (ADA) activity is typically elevated in patients with tuberculous pleural effusion (TPE), but low ADA has occasionally been reported TPE. The characteristics of these are not well-known, and erroneous exclusion the possibility TPE can result a delayed diagnosis. This study investigated who had activity.We retrospectively reviewed microbiologically or pathologically confirmed between 2012 to 2018 tertiary hospital South Korea. Patients were categorised into two groups:...
The lung cancer mortality in Korea has increased remarkably during the last 20 years, and been first leading cause of cancer-related deaths since 2000. aim current study was to examine time trends occupational carcinogens exposure period 2006-2009 South Korea, by assessing proportion burden.We defined for surveillance, developed a reporting protocol website surveillance cancer. patients were chosen from 9 participating university hospitals following 7 areas: Seoul, Incheon, Wonju, Daejeon,...
Post-intubation tracheal stenosis accounts for the greatest proportion of whole-cause stenosis. Treatment post-intubation requires a multidisciplinary approach. Surgery or an endoscopic procedure can be used, depending on type However, efficacy cryotherapy in has not been validated. Here, we report case recurring successfully treated with bronchoscopic that had previously surgery. In this case, was effective treating web-like fibrous stenosis, without requiring more Cryotherapy considered as...
Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to number reports in literature, most common tumors that spread through blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases secondary were diagnosed gastroscopy. The first patient was 66-year-old man who had primary with multiple bone subcutaneous metastases. Gastroscopy showed submucosal central umbilications fundus upper body stomach. Pathologic examination...
Objective To compare the diagnostic performance of contrast-enhanced radial T1-weighted gradient-echo 3-tesla (3T) magnetic resonance imaging (MRI) and computed tomography (CT) for detection visceral pleural surface invasion (VPSI). Visceral by non-small-cell lung cancer (NSCLC) can be classified into two types: PL1 (without VPSI), elastic layer pleura without reaching surface, PL2 (with full pleura. Materials methods Thirty-three patients with pathologically confirmed VPSI NSCLC were...
Human pulmonary dirofilariasis has been documented from many parts of the world, but not in Korea so far. We experienced a patient who had visited local clinic because chest pain for 1 month. On radiograph, coin lesion 2 cm diameter and enlargement mediastinal lymph node were shown. An exploratory lung resection was done. Pathologically complicated with necrotic pneumonia, fibrosis, infarction. At center lesion, degenerated nematode sections multilayered cuticle, thick musculature, bilateral...
Dept. of Pathology Yonsei University Wonju College Medicine, Preventive Industrial Medical Center, The Catholic Korea, Medicine and Institute Occupational Internal Korea Labor Welfare Corporation, Safety Health Research Institute, School Kyungpook National University, Chonbuk Konyang Kwandong
Perilla is an Asian grain that consumed for food ingredient, oil crops, medicinal materials through the process of roasting. A 49-year-old male has been roasting grains 10 years, who met with shortness breath during perilla seeds, but not in other situations. Serum total immunoglobulin E (IgE) level, serum eosinophil count and skin prick test didn`t showed significant results. Methacholine bronchial provocation was positive (PC20 0.31 mg/mL). Specific inhaling smoke from seeds a dual...
Abstract Background With the emergence of bronchiectasis as a common respiratory disease, epidemiological data have accumulated. However, prevalence and impact psychological comorbidities were not sufficiently evaluated. The present study examined depression its associated factors in patients with bronchiectasis. Methods This involved multicenter cohort recruited from 33 pulmonary specialist hospitals. baseline characteristics bronchiectasis-related at enrollment analyzed. Depressive...
Spirometry is regarded as the only effective method for detecting pulmonary function test (PFT) indices. In this study, a novel impedance measurement system (IPFS) developed directly assessing PFT IPFS can obtain high resolution values and remove motion artifacts through real-time base feedback. Feedback enables detection of indices using both hands convenience. showed no differences in sitting, supine, standing postures during measurements, indicating that patient posture has effect on...
We aimed to determine the effect of long-acting inhaler use adherence on acute exacerbations in treatment-naïve patients with chronic obstructive pulmonary disease (COPD) using claims data from Korean Health Insurance Review and Assessment Service July 2015−December 2016. Patients COPD aged ≥ 40 years who used inhalers were enrolled observed for 6 months. Medication was determined by medication possession ratio (MPR); categorized (MPR 80%) non-adherence < groups. Ultimately, 3959 enrolled:...
People are generally exposed to radiation from natural sources. Radon is the most important source among a naturally occurring, radioactive noble gas that odorless and tasteless. normally found at very low levels in outdoor air drinking water rivers lakes but higher indoor homes, schools, office buildings, well water. When radon undergoes decay, it expels high-energy alpha particles. The particle dose long-term exposure increases chance of developing lung cancer. second cause cancer after...
Background: Previous studies have shown that reduced levels of lung function, characterized by forced expiratory volume in 1 second (FEV1), are associated with higher respiratory events and mortality general population some chronic diseases. Chronic pulmonary aspergillosis (CPA) is a destructive, fatal disease caused Aspergillus infection non-immunocompromised patients suboptimal function. However, there limited information on the status features CPA according to FEV1. Methods: We performed...
Background Transbronchial lung biopsy (TBLB) is a valuable diagnostic tool for peripheral pulmonary lesions. The yield of TBLB reportedly ranges from 41%-60%. Many studies demonstrated the various factors that influence TBLB, including size, location, and distance carina or pleura. However, no study has evaluated effects bronchoscope diameter. We whether diameter affected TBLB. Methods reviewed records 178 patients who underwent using bronchoscopes two different diameters (5.7 mm, thick...
Background: In chronic obstructive pulmonary disease (COPD), inhaled corticosteroids (ICSs) are recommended for use by patients with frequent exacerbations and blood eosinophilia. However, ICSs often inappropriately prescribed overused. COPD studies have reported an increased risk of tuberculosis among ICS users. This study aimed to compare the according different components. Methods: was conducted using a nationwide, population-based cohort. Patients newly diagnosed between 2005 2018,...
Obstructive airway disease patients with increased variability of airflow and incompletely reversible obstruction are often categorized as having asthma-chronic obstructive pulmonary (COPD) overlap syndrome (ACOS). ACOS is heterogeneous two sub-phenotypes: asthma-ACOS COPD-ACOS. The objective this study was to determine the difference in risk exacerbation between sub-phenotypes ACOS.A total 223 exhibiting (spirometrically defined ACOS) were enrolled. These divided into COPD-ACOS according...
Background Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed assess the efficacy safety direct switch from once-daily tiotropium (TIO) 18 μg indacaterol/glycopyrronium (IND/GLY) 110/50 once daily in COPD Korea. Methods was a randomized, open-label, parallel group, 12-week trial mild-to-moderate who received TIO for ≥12 weeks prior initiation. Patients aged ≥40 years, with...
Background This study compared the bronchodilator efficacy and safety of tiotropium inhalation capsules (18µg once daily) with a ipratropium metered dose inhaler (2 puffs 20µg q.i.d.) in patients chronic obstructive pulmonary disease (COPD). Method After initial screening assessment two-week run-in period, received either 18µg daily or 40µg four times over period 4 weeks double blind, dummy, parallel group study. The outcome measures were lung function, records peak expiratory flow rate...
High flow nasal cannulae (HFNC) oxygen therapy has demonstrated an effect comparable with non-invasive ventilation (NIV). We conducted the prospective randomized controlled study to compare effectiveness between HFNC and NIV in severe AECOPD moderate hypercapnic acute respiratory failure. enrolled patients who hospitalized from January 2013 February 2015. Each group of eligible received or respectively. The primary end point was 30-day mortality. Treatment failure defined that underwent...
Studies have shown increased nontuberculous mycobacterial pulmonary disease (NTM) incidence with inhaled corticosteroid (ICS) use in patients chronic respiratory diseases; however, this association obstructive (COPD) remains insufficiently studied. Using a nationwide population-based database of the Korean National Health Insurance Service, newly diagnosed COPD (20052018) treated bronchodilators were selected. An NTM case was defined by presence first diagnostic code following bronchodilator...