A5025987939- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Education
- Thyroid Cancer Diagnosis and Treatment
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Pituitary Gland Disorders and Treatments
- Bone health and osteoporosis research
- Nutrition, Health and Food Behavior
- Obesity, Physical Activity, Diet
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Muscle and Compartmental Disorders
- Obesity and Health Practices
- Climate Change and Health Impacts
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Air Quality and Health Impacts
Seoul National University Hospital
2018-2024
Seoul National University
2011-2022
Catholic University of Korea
2006-2015
Seoul St. Mary's Hospital
2009-2015
SK Group (Japan)
2015
Lianyungang Oriental Hospital
2015
Korea National Institute of Health
2011
Yeouido St. Mary's Hospital
2010
Konyang University
2009
Pain and Rehabilitation Medicine
2007
Background To determine whether the TyG index, a product of levels triglycerides and fasting plasma glucose (FPG) might be valuable marker for predicting future diabetes. Methods A total 5,354 nondiabetic subjects who had completed their follow-up visit evaluating diabetes status were selected from large cohort middle-aged Koreans in Chungju Metabolic Disease Cohort study. The risk was assessed according to baseline calculated as ln[fasting (mg/dL) × FPG (mg/dL)/2]. median period 4.6 years....
OBJECTIVE—The Internet is used worldwide as a communication tool. To improve the quality of diabetes control, we investigated effectiveness an Internet-based blood glucose monitoring system (IBGMS) on controlling changes in HbA1c levels. RESEARCH DESIGN AND METHODS—We conducted randomized clinical trial involving 110 patients who visited outpatient clinic at Kangnam St. Mary’s Hospital for 3 months. The study subjects were treated with IBGMS 12 weeks, and control group received usual...
To investigate the long-term effectiveness of Internet-based glucose monitoring system (IBGMS) on control in patients with type 2 diabetes.We conducted a prospective, randomized, controlled trial 80 diabetes for 30 months. The intervention group was treated IBGMS, while made conventional office visits only. HbA1c (A1C) performed at 3-month intervals. For measuring stability control, SD value A1C levels each subject used as fluctuation index (HFI).The mean and HFI were significantly lower (n...
Abstract Thyroid cancer is the most common in Korea. Several susceptibility loci of differentiated thyroid (DTC) were identified by previous genome-wide association studies (GWASs) Europeans only. Here we conducted a GWAS and replication study Koreans using total 1,085 DTC cases 8,884 controls, validated these results expression quantitative trait (eQTL) analysis clinical phenotypes. The robust associations observed NRG1 gene (rs6996585, P =1.08 × 10 −10 ) this SNP was also associated with...
Underrepresentation of non-European (EUR) populations hinders growth global precision medicine. Resources such as imputation reference panels that match the study population are necessary to find low-frequency variants with substantial effects. We created a panel consisting 14,393 whole-genome sequences including more than 11,000 Asian individuals. Genome-wide association studies were conducted using and population-specific genotype array 72,298 subjects for eight phenotypes. This yields...
Abstract Aims Patient education is a very important part of diabetes care. However, until now, little data has been presented about the long‐term effectiveness structured intensive programmes (SIDEP) for people with Type 2 mellitus. Methods People ( n = 547) hospitalized from December 1999 to 2000 were randomly assigned two groups. Two hundred and nineteen patients undertook an inpatient SIDEP remaining received conventional glycaemic control without education. After discharge, all monitored...
Abstract Pancreatic stellate cells (PSCs) are involved in pancreatic inflammation and fibrosis. Recent studies have shown that blocking the renin–angiotensin system (RAS) attenuates However, there few data about direct effects of high glucose on extracellular matrix (ECM) protein synthesis angiotensin II (Ang II) induction PSCs. PSCs were isolated from male Sprague–Dawley rats cultured medium containing 5.5 mM (LG group) or 27 D ‐glucose (HG group). Levels Ang transforming growth factor‐β...
To investigate the prevalence and identify phenotype of individuals suspected to be metabolically obese but normal weight (MONW).Eight thousand nine hundred eighty-seven nondiabetic subjects aged over 40 years were selected from Chungju Metabolic disease Cohort study performed in 2003-2006 Korea. Those within highest quartile homeostasis model assessment insulin resistance (HOMA-IR) with a body mass index (BMI) between 18·5 23 kg/m(2) classified as MONW.Data on anthropometry, lipid profiles...
Metabolic health and obesity are not stable conditions, changes in the status of these conditions might lead to different clinical outcomes. We aimed determine whether metabolic or over time have any effect on risk future diabetes. Nondiabetic individuals (n = 2692) from a population-based prospective cohort study with baseline 2 follow-up examinations at 4-year intervals were included. Being "metabolically obese" (MO) was defined as being highest quartile TyG index (ln [fasting...
Background: Papillary thyroid microcarcinoma (PTMC) detection has been increasing explosively with the recent improvement and application of new diagnostic tools. However, associations between clinical, histopathological, molecular findings are often not fully evaluated in reaching a decision for treatment PTMC. Objective: To retrospectively evaluate patients diagnosed PTMC terms clinical histopathological features immunohistochemical specific markers, thereby provide an association disease...
Abstract Aims We investigated whether cardiovascular autonomic neuropathy (CAN) is associated with acute ischaemic stroke in patients Type 2 diabetes. Methods From 1999 to 2000, function tests were conducted diabetes ( n = 1458). Patients followed up between 2006 and 2007. Standard for CAN measured heart rate variability parameters [expiration‐to‐inspiration (E/I) ratio, responses the Valsalva manoeuvre standing]. Using American Diabetes Association criteria, scores determined from results...
There is increasing evidence that the retinoic acid receptor-related orphan receptor α (RORα) plays an important role in regulation of metabolic pathways, particularly fatty and cholesterol metabolism; however, RORα hepatic lipogenesis has not been studied. Here, we report attenuates steatosis, probably via activation adenosine monophosphate (AMP)-activated protein kinase (AMPK) repression liver X (LXRα). First, its activator, sulfate (CS), induced phosphorylation AMPK, which was accompanied...
This study aimed to compare the effects of sitagliptin on glycemic change and 24-h blood glucose variability with those sulfonylurea glimepiride.A 4-week randomized double blind-labeled prospective design was used. We recruited 33 patients who had been treated metformin for at least 2 months. Each participant prescribed randomly assigned either (100 mg) or glimepiride (2 group. Continuous monitoring (CGM) used monitor changes 3 successive days in both groups baseline follow-up. Glycemic were...
Background/Aims Gastrointestinal (GI) symptoms are common among patients with non-insulin dependent diabetes mellitus (NIDDM). Our aim was to investigate the frequency of chronic GI in Korean NIDDM. Methods A cross-sectional survey, using a reliable and valid questionnaire, performed clinics from seven hospitals Catholic University Korea. Results total 608 (249 males 359 females, mean age 53.7±10.9 years) were investigated. The frequencies weekly heartburn acid regurgitation (esophageal...
The present study was aimed to assess the prevalence, awareness, treatment, control of hypertension, and related risk factors in a Korean population. A cross-sectional conducted rural area South Korea from 2005 2006. Subjects (n = 6388) were selected individuals aged 40 years or older by stratified random cluster sampling. age-adjusted prevalence hypertension 43.8 % (43.1 men, 44.9 women). 60.1%, 91.7%, 27.2%, respectively. In old age (≥ 60 old) low waist circumference (< 90 cm) positively...
Abstract Pancreatic islet fibrosis observed in Type 2 diabetes is one of the major factors leading to progressive β‐cell loss and dysfunction. Despite its importance, mechanism islet‐restricted fibrogenesis associated with pancreatic stellate cell (PSC) activation proliferation remains be defined. Therefore, we studied whether islet‐specific environment represented by hyperglycemia hyperinsulinemia had additive effects on cultured rat PSCs. Cells were stimulated activate proliferate glucose...