A5101594397- Effects and risks of endocrine disrupting chemicals
- Skin Protection and Aging
- Advancements in Transdermal Drug Delivery
- Animal testing and alternatives
- Natural product bioactivities and synthesis
- Anesthesia and Neurotoxicity Research
- Medicinal Plants and Neuroprotection
- Microbial Metabolic Engineering and Bioproduction
- Healthcare and Environmental Waste Management
- Ginseng Biological Effects and Applications
- Dental Anxiety and Anesthesia Techniques
- Cholinesterase and Neurodegenerative Diseases
- Contact Dermatitis and Allergies
- Steroid Chemistry and Biochemistry
- Phytochemistry and Biological Activities
- Neuroscience and Neuropharmacology Research
- Dermatologic Treatments and Research
- Intensive Care Unit Cognitive Disorders
- Medicinal Plants and Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Pediatric Pain Management Techniques
- Pharmacological Effects of Natural Compounds
- Enzyme Catalysis and Immobilization
- Bee Products Chemical Analysis
- Chemistry and Chemical Engineering
Korea Testing Laboratory
2020-2024
Konkuk University
2021
Background Lidocaine has been widely used as a short-acting local anesthetic agent to reduce the pain caused by needle insertion. Dissolving microneedles (DMNs), which are minimally invasive, can effectively deliver drugs overcoming oral mucosal barrier and relieving patient discomfort.Methods solution prepared mixing lidocaine-HCl hyaluronic acid was fabricate lidocaine HCl-encapsulated DMNs (oral Li-DMNs) via centrifugal lithography. The dissolution, penetration ability, transmucosal drug...
Bisphenol F is a substitute material for bisphenol A and widely used in household products as raw polycarbonate resin, epoxy plastic reinforcement. It known to be mainly food containers, thermal paper receipts, coatings water pipes. In some countries, has been detected drinking human urine samples. However, due the lack of safety evaluation data on F, it difficult establish appropriate guidelines proper use substance, social anxiety increasing accordingly. This study investigated use,...
Here, we report a bienzymatic cascade to produce β-amino acids as an intermediate for the synthesis of leading oral antidiabetic drug, sitagliptin. A whole-cell biotransformation using recombinant Escherichia coli coexpressing esterase and transaminase were developed, wherein desired expression level each enzyme was achieved by promotor engineering. The small-scale reactions (30 ml) performed under optimized conditions at varying amounts substrate (100-300 mM) resulted in excellent...
Wild ginseng has better pharmacological effects than cultivated ginseng. However, its industrialization is limited by the inability to grow wild on a large scale. Herein, we demonstrate how optimize production through cultivation, and enhance concentrations of specific ginsenosides fermentation. In study, also evaluated ability fermented cultured root extract (HLJG0701-β) inhibit acetylcholinesterase (AChE), as well neuroprotective antioxidant activity.
The efficacy of wheat extract oil (WEO), standardized to glucosylceramides, for protecting against ultraviolet B (UVB)-induced damage skin barrier function was assessed using the SHK-1 hairless mouse model and two human cell lines, namely, CCD-986sk HeCaT. ability repeated oral administration 30, 60, 120 mg WEO/kg/day 12 weeks prevent SKH-1 mice induced by UVB irradiation evaluated. results demonstrated that UVB-induced water evaporation (transepidermal loss, TEWL) significantly decreased...
This study investigated the neuroprotective effects of Dendropanax morbifera leaves and stems (DMLS) water extract on scopolamine (SCO)-induced memory impairment in mice. First, we conducted experiments to determine protective effect DMLS neuronal cells. Treatment with showed a significant against neurotoxicity induced by Aβ(25–35) or H2O2. After confirming DMLS, animal studies. We administered orally at concentrations 125, 250, 375 mg/kg for 3 weeks. In Y-maze test, SCO decreased...
In the present study, we prepared an ethanol extract from flowers of Styphnolobium japonicum L. (SJFE) and found that it contains rutin as a major constituent well quercetin kaempferol isorhamnetin minor components. lipopolysaccharide-stimulated RAW 264.7 macrophages, observed SJFE significantly inhibited production nitric oxide expression inflammatory biomarkers such inducible NO synthase, cyclooxygenase-2, interleukin (IL)-6, IL-1β significantly. Based on these in vitro results,...
Bisphenol F (BPF) is classified as a harmful substance by the U.S. Environmental Protection Agency. Although previous studies focused on human exposure to BPF via direct consumption or inhalation, few investigators assessed potential toxicological effects following skin contact. The aim of this study was examine (1) degree and pattern which absorbed onto in vivo, (2) determination toxicity safety using tests: acute dermal; 28-day repeat irritation; an eye sensitization. As indicated amount...
The efficacy of wheat extract oil (WEO), standardized to glucosylceramides, for protecting against ultraviolet B (UVB)-induced damage skin barrier function was assessed using the SHK-1 hairless mouse model and two human cell lines, namely, CCD-986sk HeCaT. ability repeated oral administration 30, 60, 120 mg WEO/kg/day 12 weeks prevent SKH-1 mice induced by UVB irradiation evaluated. To complement this work, better understand mechanism(s) through which dietary ingredient works, changes in...
443 AgNP products (highest subgroup) among 1833 nanoproduct [2].Although antibacterial nanoproducts containing AgNPs are now widely commercially available, most AgNP-containing sold without providing any information on their physicochemical properties and health & safety data.In countries, consumer not covered by current SDS (Safety Data Sheet) regulations that require disclosure of data.Most manufacturers only provide product specifications based
1Department of Anesthesiology, Sanggye-Paik Hospital Inje University; 2Department UVA Hospital, USA