A5100330928- Natural product bioactivities and synthesis
- Cardiac Valve Diseases and Treatments
- Phytochemistry and Biological Activities
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aortic Disease and Treatment Approaches
- NF-κB Signaling Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Infective Endocarditis Diagnosis and Management
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Cell death mechanisms and regulation
- Bioactive natural compounds
- Ginseng Biological Effects and Applications
- Inflammasome and immune disorders
- Dynamics and Control of Mechanical Systems
- Bacteriophages and microbial interactions
- Bone health and treatments
- Robotic Mechanisms and Dynamics
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Pusan National University
2007-2025
Korea Research Institute of Bioscience and Biotechnology
2016-2025
Samsung (South Korea)
2023-2025
Korea University of Science and Technology
2024-2025
Yuhan (South Korea)
2025
University of Ulsan
1998-2024
Ulsan College
2010-2024
Catholic University of Korea
2013-2024
Korea Testing Laboratory
2021-2024
Seoul National University of Science and Technology
2024
The timing and indications for surgical intervention to prevent systemic embolism in infective endocarditis remain controversial. We conducted a trial compare clinical outcomes of early surgery conventional treatment patients with endocarditis.
Gefitinib has shown high response rate and improved progression-free survival (PFS) in never-smokers with lung adenocarcinoma (NSLAs). We compared efficacy of gefitinib gemcitabine cisplatin (GP) chemotherapy this group patients as first-line therapy.In randomized phase III trial, a total 313 Korean stage IIIB or IV adenocarcinoma, Eastern Cooperative Oncology Group performance status 0 to 2, adequate organ function were randomly assigned receive either (250 mg daily) GP (gemcitabine 1,250...
The timing and indications for surgical intervention in asymptomatic patients with severe aortic stenosis remain controversial.In a multicenter trial, we randomly assigned 145 very (defined as an aortic-valve area of ≤0.75 cm2 either jet velocity ≥4.5 m per second or mean transaortic gradient ≥50 mm Hg) to early surgery conservative care according the recommendations current guidelines. primary end point was composite death during within 30 days after (often called operative mortality) from...
The optimal timing of surgical intervention remains controversial in asymptomatic patients with very severe aortic stenosis. We therefore compared the long-term results early surgery and a conventional treatment strategy.From 1996 to 2006, we prospectively included total 197 consecutive (99 men; age, 63+/-12 years) Patients were excluded if they had angina, syncope, exertional dyspnea, ejection fraction <0.50, significant mitral valve disease, or age >85 years. Very stenosis was defined as...
Purpose This trial was conducted to determine the optimal duration of chemotherapy in Korean patients with advanced non–small-cell lung cancer (NSCLC). Patients and Methods stages IIIB IV NSCLC who had not progressed after two cycles were randomly assigned receive either four (arm A) or B) more third-generation, platinum-doublet treatment. Results Of 452 enrolled patients, 314 groups. One-year survival rates 59.0% arm A 62.4% B, difference 3.4% (95% CI, −8.0 4.8) met predefined criteria for...
Background— For patients with ischemic mitral regurgitation (MR), it is not clear whether adjunctive valve (MV) repair at the time of coronary artery bypass graft surgery (CABG) beneficial. We sought to test hypothesis that MV CABG superior alone in improving MR without increasing operative or long-term mortality. Methods and Results— A total 107 consecutive moderate severe MR, as determined by preoperative echocardiography, underwent concomitant (repair group, n=50) only (CABG n=57). Degree...
Using a simple method of mass production green carbon nanotags (G-tags) from harmful cyanobacteria, we developed an advanced and efficient imaging platform for the purpose anticancer therapy. Approximately 100 grams G-tags per kilograms cyanobacteria were prepared using our eco-friendly approach. The possess high solubility, excellent photostability low cytotoxicity (<1.5 mg/mL 24 h). Moreover, doxorubicin-conjugated (T-tags; >0.1 mg/mL) induced death in cancer cells (HepG2 MCF-7) in-vitro...
The conventional carbonization process for synthesizing hard carbons (HCs) requires high-temperature furnace operations exceeding 1000 °C, leading to excessive energy consumption and lengthy processing times, which necessitates the exploration of more efficient synthesis methods. This study demonstrates rapid preparation HC anodes using intense pulsed light (IPL)-assisted photothermal without prolonged complex typical traditional A composite film microcrystalline cellulose (MCC)...
Two-dimensional SnSeX (X = 1, 2) has emerged as a promising candidate for NO2 chemiresistive sensor due to remarkable affinity gas adsorption. Although their sensing mechanism primarily relies on direct charge transfer, the underlying mechanisms of SnSe and SnSe2 remain unclear, despite various reported successes in phase engineering SnSeX. Here, we investigate hydrothermal route via 1-dodecanethiol (1-DDT), which served stabilizer, comprehensively demonstrate phase-dependent detection...
Background— Surgical indications to prevent systemic embolism in infective endocarditis (IE) remain controversial. We sought compare clinical outcomes of early surgery with conventional treatment IE patients embolic only. Methods and Results— From 1998 2006, we prospectively enrolled 132 consecutive (86 men; age, 49±17 years) definite IE. Patients were included if they had a left-sided native valve vegetation. The choice or was at the discretion attending physician. Early performed on 64 (OP...
Docosahexaenoic acid (DHA) is an ω-3 polyunsaturated fatty that essential in brain development and has structural signaling roles. Acute DHA administration neuroprotective promotes functional recovery animal models of adult spinal cord injury (SCI). However, the mechanisms underlying this have not been fully characterized. Here we investigated effects acute intravenous bolus delivered after SCI characterized DHA-induced neuroplasticity within injured cord. We found robust sprouting uninjured...
The persistence of significant tricuspid regurgitation (TR) after percutaneous mitral valvuloplasty (PMV) is known to be an independent predictor adverse outcome in stenosis (MS). However, it remains unclear whether valve (MV) surgery combined with surgical correction TR the better treatment option than PMV patients severe MS and functional TR.We included a total 92 consecutive (18 men, age 49+/-13 years) TR, who were potential candidates for from 1997 2005, exclusion criteria defined as...
Avicularin, quercetin-3-<TEX>${\alpha}$</TEX>-L-arabinofuranoside, has been reported to possess diverse pharmacological properties such as anti-inflammatory and anti-infectious effects. However, the underlying mechanism by which avicularin exerts its activity not clearly demonstrated. This study aimed elucidate of in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Avicularin significantly inhibited LPS-induced excessive production pro-inflammatory mediators nitric oxide (NO)...
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there been few reports about the effect mechanism of compounds in colorectal cancer. Heat shock proteins (HSPs) are molecular chaperones that prevent cell death. Their expression significantly elevated many tumors accompanied by increased proliferation, metastasis poor response chemotherapy. In this study, we investigated cytotoxicity four bioactive coffee, namely, caffeine, caffeic acid, chlorogenic...
Stroke is a complex neurodegenerative disorder with clinically high prevalence and mortality. Despite many efforts to protect against ischemic stroke, its incidence related permanent disabilities continue increase. In this study, we found that pretreatment phlorofucofuroeckol (PFF), isolated from brown algae species, significantly increased cell viability in glutamate-stimulated PC12 cells. Additionally, cells showed irregular morphology, but PFF resulted improved which resembled cultured...
Cancer-related fatigue (CRF) is a common symptom and has negative impact on prognosis in cancer patients. CRF could be improved by Korean red ginseng (KRG).For this randomised double-blinded trial, colorectal patients who received mFOLFOX-6 were randomly assigned to either KRG 2000 mg/day (n = 219) or placebo for 16 weeks. was evaluated using the mean area under curve (AUC) change from baseline of brief inventory (BFI) as primary endpoint. Fatigue-related quality life, stress, adverse events...