A5100604983- Gastric Cancer Management and Outcomes
- Silk-based biomaterials and applications
- Drug Transport and Resistance Mechanisms
- Knee injuries and reconstruction techniques
- Epigenetics and DNA Methylation
- Toxin Mechanisms and Immunotoxins
- Cancer Cells and Metastasis
- Chemotherapy-induced organ toxicity mitigation
- Colorectal Cancer Screening and Detection
- Wnt/β-catenin signaling in development and cancer
- Toxoplasma gondii Research Studies
- Helicobacter pylori-related gastroenterology studies
- melanin and skin pigmentation
- Tissue Engineering and Regenerative Medicine
- Total Knee Arthroplasty Outcomes
- Plant Gene Expression Analysis
- Phonetics and Phonology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Eosinophilic Esophagitis
- Neuroblastoma Research and Treatments
- Orthopaedic implants and arthroplasty
- Heme Oxygenase-1 and Carbon Monoxide
- Wireless Body Area Networks
- Insect symbiosis and bacterial influences
- Ovarian cancer diagnosis and treatment
Rutgers, The State University of New Jersey
2021-2024
Konyang University
2022-2024
Korea Institute of Science and Technology
2022-2023
Gangneung–Wonju National University
2023
Daejeon Sun Hospital
2020-2021
Quantitative BioSciences
2021
Seoul National University
2017-2020
Agency for Science, Technology and Research
2020
Kyungpook National University
2018
Kangwon National University
2015-2017
Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial–mesenchymal transition (EMT) programs and the induction of tissue-invasive activity, but pro-oncogenic events capable regulating activity remain largely uncharacterized. Herein, we demonstrate that p53 loss-of-function or mutation promotes EMT by de-repressing protein activity. In absence wild-type function, Snail1-dependent activated in colon, breast, lung carcinoma...
With the completion of human draft genome sequence, efforts are now devoted to identifying new genes. We have developed a computer-based strategy that utilizes EST database identify genes could be targets for immunotherapy cancer or involved in multistep process cancer.Utilizing our screening strategy, we identified cluster expressed sequence tags (ESTs) highly breast cancer. Northern blot and reverse transcriptase polymerase chain reaction (RT-PCR) analyses demonstrated tissue specificity...
Combining a computer-based screening strategy and functional genomics, we previously identified MRP9 (ABCC12), member of the ATP-binding cassette (ABC) superfamily. We now show that gene has two major transcripts 4.5 1.3 kb. In breast cancer, normal breast, testis, transcript is kb in size encodes 100-kDa protein. The protein predicted to have 8 instead 12 membrane-spanning regions. When compared with closely related ABC family members, it lacks transmembrane domains 3, 4, 11, second...
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there been few reports about the effect mechanism of compounds in colorectal cancer. Heat shock proteins (HSPs) are molecular chaperones that prevent cell death. Their expression significantly elevated many tumors accompanied by increased proliferation, metastasis poor response chemotherapy. In this study, we investigated cytotoxicity four bioactive coffee, namely, caffeine, caffeic acid, chlorogenic...
Bile acids are synthesized from cholesterol and play an important role in regulating intestinal microflora. The different degrees of hydrophobicity acidity individual bile may affect their antimicrobial properties. We examined the effects on various microorganisms vitro confirmed whether these remain consistent vivo. Using human acids, including ursodeoxycholic acid, cholic chenodeoxycholic deoxycholic lithocholic a disc diffusion test was performed, rodent model created to determine each...
MRSA is a multidrug-resistant bacterial pathogen of acute clinical importance, infecting many thousands individuals globally each year. The essential cell division protein FtsZ has been identified as an appealing target for the development new drugs to combat infections.
Consistent uptake of colorectal cancer (CRC) screening is important to reduce the incidence and mortality from advanced-stage CRC increase survival rate patients. We conducted a longitudinal study determine factors affecting compliance in Korean adults using individual-level linked data National Health Nutrition Examination Survey, Insurance Service, Review Assessment Service. selected 3,464 aged 50-79 years as population followed them for 12 (January 2007-December 2018). The outcome...
Toxoplasma gondii is a parasite that primarily infects through the oral route. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) play crucial roles in immune responses generated during parasitic infection and also drive inflammatory response against invading parasites. However, little known about regulation of NLRs inflammasome activation T. gondii-infected human small intestinal epithelial (FHs 74 Int) cells. FHs Int cells infected with were subsequently evaluated for...
This study aimed to synthesize and evaluate the anti-inflammatory activity of 3-substituted-indolin-2-one derivatives. Cell viability derivatives was measured with EZ-Cytox reagent; interleukin (IL)-6, tumor necrosis factor (TNF)-α, inducible NOS mRNA levels were using Taqman qRT-PCR; pro-inflammatory cytokine IL-6 TNF-α determined ELISA kits; phosphorylation Akt, JNK, ERK, p38, p65, IκB protein by immunoblotting. Among nineteen synthesized, 3-(3-hydroxyphenyl)-indolin-2-one showed highest...
Krukenberg tumor, a rare metastatic ovarian tumor arising from gastrointestinal adenocarcinoma mainly, tends to occur in premenopausal females.Finding the origin of is crucial for determining prognosis.In Eastern countries, most common stomach cancer, which
Narrow band imaging provides an accurate diagnosis of colonic polyps. However, these diagnostic modalities are not used as standard endoscopic tools in most institutions. This study aims to investigate whether the chicken skin mucosa (CSM) surrounding colon polyp yields additional information about colorectal polyps, including histological differentiation neoplastic and non-neoplastic under conventional white light colonoscopy.This prospectively observed 173 patients who underwent...
Purpose:The object of this study was to determine the shortest possible distances antero-medial (AM) and postero-lateral (PL) guide wire tunnel positions required prevent femoral bone communication in double-bundle anterior cruciate ligament (ACL) reconstruction using human cadaver knees.Materials Methods: The centers AM PL bundles 16 cadaveric knees were drilled with wires wires, measured upon entrance into bone.Femoral drilling performed transportal technique.The diameters graft 8 mm 6 mm,...
This study aimed to explore socio-economic factors and medical conditions that affect regular stomach cancer (SC) screening among Korean adults.
Background and Objectives Acoustic analysis of voice could be influenced so much by the quality files which were recorded recording device. In clinical practice, that program directly or portable digital device analyzed mostly. This study examined feasibility using Galaxy smartphone recordings for acoustic voice. Materials Methods measures compared between signals from 30 normal speakers (15 males 15 females) through smartphone, CSL. Fo, jitter, shimmer, NHR (Noise-Harmony ratio) Formant...
Gastric carcinoid tumor is a rare neoplasm and it accounts for only 0.3% of all the gastric neoplasms. has high incidence in patients who are aged between 50 70 years, usually develops over long period time. Type I tumors associated with autoimmune atrophic gastritis pernicious anemia, there few cases carcinoids other diseases like Sjögren's syndrome thyroiditis. Here, we report on case recurrent type 42-years old woman suffered systemic lupus erythematosus.
Abstract Twenty novel cardamonin derivatives were synthesized and evaluated for antiproliferative activity against four cancer cell lines (HT‐29, DLD‐1, MDA‐MB‐231, HepG2). Among the derivatives, SWA2 showed most potent effects with an IC 50 value of 4.43–11.0 μM three except HepG2. Further investigation that induced death by apoptosis. Flow cytometry analysis treatment increased ratio apoptotic dead cells. western blot revealed cleaved PARP. In summary, can be utilized as a lead structure...
The diagnostic value of ileoscopy is not well established, and its routine practice controversial. We aimed to investigate the biopsy for macroscopically abnormal lesions in terminal ileum identify association between endoscopic indications findings presence significant disease. This retrospective study included 551 patients who underwent (TI) during colonoscopy February 2000 June 2019. Biopsy results were analyzed relation gross findings. Significant disease was defined as a case which...
Background/Aims: In 2019, the American Society for Gastrointestinal Endoscopy (ASGE) established clinical predictors choledocholithiasis.Our study was designed to evaluate these within Korean context, establish cutoff values, and develop a predictive model. Methods:This retrospective analyzed patients who underwent laparoscopic cholecystectomy.The relationships between choledocholithiasis including age, blood tests, imaging findings were assessed through univariate multivariate logistic...