A5102483925- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Toxoplasma gondii Research Studies
- Air Quality Monitoring and Forecasting
- Energy and Environment Impacts
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Cardiac Valve Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Animal Nutrition and Physiology
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Transplantation: Methods and Outcomes
- Pesticide Residue Analysis and Safety
- Gout, Hyperuricemia, Uric Acid
- Turtle Biology and Conservation
- Lipid metabolism and disorders
- Sirtuins and Resveratrol in Medicine
- Water Quality Monitoring Technologies
- FOXO transcription factor regulation
- Neurological Disease Mechanisms and Treatments
Guangdong Medical College
2019-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
Tianjin Agricultural University
2021-2024
Wuhan University
2021-2023
Affiliated Hospital of Guangdong Medical College Hospital
2023
Wuhan Donghu University
2021-2022
Chinese Academy of Fishery Sciences
2021
Weatherford College
2021
Second Hospital of Shandong University
2016-2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020
Abstract Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in elderly. Reactive oxygen species (ROS) play important role OA development; they may activate NLRP3 inflammasome, thereby inducing secretion proinflammatory IL-1β and IL-18, leading to aggravation downstream response. Nrf2 a key transcription factor regulates expression antioxidant enzymes protect against oxidative stress tissue damage. We aimed explore underlying mechanism...
Exposure to fine particulate matter (PM2.5) has been reported increase the risks of chronic kidney disease. However, limited research assessed effect PM2.5 and its constituents on renal function, underlying mechanism not well characterized. We aimed evaluate association with indicators explore roles systematic oxidative stress inflammation in association. conducted a longitudinal panel study among 35 healthy adults before-, intra- after-the 2019 Wuhan Military World Games. repeatedly...
Three hundred twenty Cobb 500 broiler breeder pullets at 21 wk of age were selected from a flock fed according to Breeder Management Guide specifications. One sixty switched ad libitum feeding, and the remaining 160 continued be control-fed. The photostimulated 22 maintained until 36.5 wk. Plasma samples obtained, BW was determined, hens killed for determination body composition following periods: 24 h prior photostimulation, 2.5 after first egg, peak egg production. Compared with...
Aberrant alternative splicing (AS) has been highly involved in the tumorigenesis and progression of most cancers. The potential role AS invasive breast cancer (IBC) remains largely unknown. In this study, RNA sequencing IBC samples from Cancer Genome Atlas was acquired. events were screened by conducting univariate multivariate Cox analysis least absolute shrinkage selection operator regression. total, 2146 survival-related identified 1551 parental genes, which 93 related to prognosis, a...
Particulate matter pollution could increase the risk of kidney disease, while evidence for ozone exposure is less well-established. Here, we aimed to evaluate effect on renal function and explore mechanisms. We first conducted a cross-sectional study based Wuhan Chronic Disease Cohort Study baseline information. recruited 2699 eligible participants, estimated their residential concentrations, collected fasting peripheral blood samples biochemical analysis calculated glomerular filtration...
Results of previous studies about the acute effects fine particulate matter (PM2.5) on blood lipids were inconsistent. This study aimed to quantify short-term PM2.5 and estimate modifying role insulin resistance, reflected by homeostasis model assessment resistance (HOMA-IR). From September 2019 January 2020, recruited 70 healthy adults from Wuhan University for a total eight repeated data collections. At each visit, three consecutive days monitored personal exposure PM2.5, then physical...
BACKGROUND:This study, by regulating the expression level of microRNA-21 (miRNA-21) in antigen-1+ (Sca-1+) cardiac stem cells (CSCs), examined role miRNA-21 migration, proliferation, and differentiation Sca-1+ CSCs, explored use treatment heart-related diseases mice. MATERIAL AND METHODS:The CSCs 20 healthy 2-month-old C57BL/6 mice were collected our study. Immunomagnetic beads used to separate prepare pure which further flow cytometry. The samples assigned 4 groups: blank group, mimic...
This study was designed to investigate the long non‑coding RNA (lncRNA)‑metastasis associated lung adenocarcinoma transcript 1 (MALAT1) expression in patients with coronary atherosclerosis and its predictive value for in‑stent restenosis. Ninety‑five heart disease who came our hospital treatment underwent stent implantation were selected as a research group (RG), 95 volunteers undergoing physical examination did not suffer from during same period control (CG). MALAT1 of subjects both groups...
Toxoplasma gondii is a parasite that primarily infects through the oral route. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) play crucial roles in immune responses generated during parasitic infection and also drive inflammatory response against invading parasites. However, little known about regulation of NLRs inflammasome activation T. gondii-infected human small intestinal epithelial (FHs 74 Int) cells. FHs Int cells infected with were subsequently evaluated for...
Epidemiological evidence of short-term fine particulate matter (PM2.5) exposure on blood pressure (BP), heart rate (HR) and related inflammation biomarkers has been inconsistent. We aimed to explore the acute effect PM2.5 BP, HR mediation biomarkers. A total 32 healthy college students were recruited perform 4 h at two sites with different concentrations in Wuhan between May 2019 June 2019. The individual levels concentration, BP measured hourly for each participant. Blood was drawn from...
Abstract The biodegradable polymer poly-β-hydroxybutyrate (PHB) is a promising carbon source for biological mitigation of nitrogen pollution, significant problem in aquaculture that physical and chemical methods have not provided comprehensive solution. Here we investigated the impact PHB on zero-water-change largemouth bass culture by 30- 40-day experiments. loaded into filter circulation pump at 4 g L − 1 , optimum value determined first experiment, significantly reduced levels nitrate...
Background: PI3K/AKT pathway plays major roles in regulating cardiomyocyte metabolism.The of and FOXO3a mediating high glucose-induced apoptosis cardiomyocytes remain unclear.Objectives: In this experimental study, we investigated the mechanisms hyperglycemiainduced neonatal rat ventricular myocytes (NRVMs).Materials Methods: NRVMs were adopted as cell model to investigate hyperglycemia-induced cardiomyocytes.Annexin-V-FITC staining PI used evaluate under indicated conditions serum...
Toxoplasma gondii, an intracellular protozoan parasite that infects one-third of the world's population, has been reported to hijack host cell apoptotic machinery and promote either anti- or proapoptotic program depending on virulence load type. However, little is known about regulation human FHs 74 small intestinal epithelial viability in response T. gondii infection. Here we show RH strain tachyzoite infection ESP treatment Int cells induced apoptosis, mitochondrial dysfunction ER stress...
Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Adenosine a purine nucleoside involved in numerous physiological processes; however, role of adenosine receptors T. gondii-induced trophoblast cell function has not been investigated until now. The goal present study was to evaluate signaling pathways regulated by using HTR-8/SVneo model infection. HTR8/SVneo human extravillous cells were infected with or without and then...
This study aimed at observing the expression of lncRNA‐ANRIL (ANRIL) before and after treatment its predictive value for short‐term survival in patients with coronary heart disease (CHD). Altogether, 112 CHD admitted to hospital were enrolled as a group (SG), which was divided into pretreatment (preSG) posttreatment (postSG). Further 72 healthy people undergoing physical examinations during same period control (CG). Peripheral blood collected from subjects three groups, detect level serum...