A5100448699- interferon and immune responses
- Aquaculture disease management and microbiota
- Toxoplasma gondii Research Studies
- vaccines and immunoinformatics approaches
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Immune cells in cancer
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture Nutrition and Growth
- Amoebic Infections and Treatments
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- Heavy metals in environment
- Microbial Fuel Cells and Bioremediation
- Rabies epidemiology and control
- Transgenic Plants and Applications
- CAR-T cell therapy research
- Pregnancy and preeclampsia studies
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
Guangdong Medical College
2010-2024
Ministry of Agriculture and Rural Affairs
2022-2023
Chinese Academy of Fishery Sciences
2022-2023
Nanjing Medical University
2023
Nanjing Agricultural University
2022
Southern Medical University
2022
University of Waterloo
2022
Chungnam National University
2021
University of Toronto
2019
University of Jinan
2018
Transport is essential in cross-regional culturing of juvenile fish. Largemouth bass (Micropterus salmoides) often exhibit decreased vitality and are susceptible to disease after transportation. To study the effects transport stress on largemouth bass, juveniles (average length: 8.42 ± 0.44 cm, average weight 10.26 0.32 g) were subjected a 12 h simulated transport, then subsequently, allowed recover for 5 d. Liver intestinal tissues collected at 0, 6 d recovery. Oxidative immunological...
We attempted to augment immunity melanoma antigens using interleukin-12 (IL-12) with aluminum hydroxide (alum) for sustained release or granulocyte macrophage colony-stimulating factor (GM-CSF) added a multipeptide vaccine.Sixty patients high-risk resected were randomized receive peptides gp100(209-217) (210M), MART-1(26-35) (27L), and tyrosinase(368-376) (370D) adjuvant Montanide ISA 51 either IL-12 at 30 ng/kg alum (group A), 100 B), 250 mug GM-CSF C).Three had stage IIC (5%), 50 III...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses—including SARS-CoV, MERS-CoV, SARS-CoV-2—is the papain-like protease (PLpro). PLpro cleaves part viral replicase polyproteins into non-structural protein subunits, which are essential replication cycle. Additionally, can cleave both ubiquitin ubiquitin-like ISG15 host...
Dissolved oxygen (DO) is a key factor affecting the health of aquatic organisms in an intensive aquaculture environment. In this study, largemouth bass (Micropterus salmoides) were subjected to acute hypoxic stress for 96 h (DO: 1.00 mg/L) followed by recovery under sufficient DO conditions 7.50 h. Serum biochemical indices, intestinal histomorphology, transcriptome, and microbiota compared between hypoxia-treated fish those control group. The results showed that hypoxia caused oxidative...
Trichomonas vaginalis causes lesions on the cervicovaginal mucosa in women; however, its pathogenesis remains unclear. We have investigated involvement of endoplasmic reticulum (ER) induction apoptosis by T. and molecular mechanisms human cervical cancer SiHa cells.Apoptosis, reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), ER stress response Bcl-2 family protein expression were evaluated using immunocytochemistry, flow cytometry,...
The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly the intracellular formation its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at C-5' center were sought. This paper describes facile stereospecific synthesis, where necessary, such C-5'-methylated
To investigate the osteogenic potential of human embryonic stem cell-derived exosomes (hESC-Exos) and their effects on differentiation umbilical cord mesenchymal cells (hUCMSCs).
Toxoplasma gondii is an apicomplexan zoonotic protozoan parasite that infects most species of warm-blooded animals, including humans. The heavy incidence and severe or lethal damage caused by T. infection clearly indicate a need for the development effective vaccine. GRA8 member dense granules protein family used as marker acute infection. In present study, we evaluated protective immunity induced DNA vaccination based on recombinant eukaryotic plasmid, pDsRed2-GRA8, against toxoplasmosis in...
Toxoplasma gondii, an intracellular protozoan parasite that infects one-third of the world's population, has been reported to hijack host cell apoptotic machinery and promote either anti- or proapoptotic program depending on virulence load type. However, little is known about regulation human FHs 74 small intestinal epithelial viability in response T. gondii infection. Here we show RH strain tachyzoite infection ESP treatment Int cells induced apoptosis, mitochondrial dysfunction ER stress...
The HIV fusion inhibitor T20 has been approved to treat those living with HIV/AIDS, but treatment gives rise resistant viruses. Using combinatorial phage-displayed libraries, we applied a saturation scan approach dissect the entire sequence for binding prefusogenic five-helix bundle (5HB) mimetic of HIV-1 gp41. Our data set compares all possible amino acid substitutions at positions, and affords complete view complex molecular interactions governing 5HB. revealed that 12 its 36 positions...
Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Adenosine a purine nucleoside involved in numerous physiological processes; however, role of adenosine receptors T. gondii-induced trophoblast cell function has not been investigated until now. The goal present study was to evaluate signaling pathways regulated by using HTR-8/SVneo model infection. HTR8/SVneo human extravillous cells were infected with or without and then...
Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. exhibit cytotoxicity have been approved by the FDA treat multiple hematological malignancies, such as hairy cell leukemia cutaneous T-cell lymphoma. However, most of internalized immunotoxin is degraded in lysosomes, only approximately 5% free toxin escapes cytosol cytotoxicity. Many studies improved immunotoxins engineering fragment reduce...
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This study investigates the relationship between serum homocysteine, blood lipids, and perinatal outcomes in patients with diet-controlled gestational diabetes mellitus (GDM) those normal glucose tolerance (NGT). A prospective cohort of 150 GDM pregnant women NGT, all delivering at our hospital, were selected based on predefined criteria. Data demographics, physical parameters, compiled. Blood samples for fasting plasma (FPG), homocysteine (Hcy), total cholesterol (TC), triglycerides (TG),...
To establish an effective model for cellular senescence, human embryo lung fibroblast cells (MRC-5) were cultured in D-galactose (D-Gal) medium respectively, as control, same concentration of D-glucose (D-Glu) was used.Decrease cell proliferation, increase senescence associated β-galactosidase activity, up-expression p21 protein, and cycle arrest at S-phage observed D-Gal-treated cells.Meanwhile, showed the significant increased ROS MDA level decreased SOD activity.Furthermore, mitochondrial...
s: Abstracts for the 20th Annual Scientific Meeting of International Society Biological Therapy Cancer (Primary Authors are Italicized): CELLULAR THERAPIES FOR SOLID AND LIQUID TUMORS