A5100453121- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Multiple Myeloma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Protein Degradation and Inhibitors
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
- Ferroptosis and cancer prognosis
- Chronic Lymphocytic Leukemia Research
- Histone Deacetylase Inhibitors Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Anomalies and Treatments
- Toxin Mechanisms and Immunotoxins
- Immune cells in cancer
- Antifungal resistance and susceptibility
- RNA and protein synthesis mechanisms
- Medical Imaging Techniques and Applications
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Foreign Body Medical Cases
- Fungal Infections and Studies
- Neurosurgical Procedures and Complications
- Neurogenetic and Muscular Disorders Research
- Cancer Mechanisms and Therapy
Nanjing Traditional Chinese Medicine Hospital
2025
Wuhan Pulmonary Hospital
2024
Nanjing Medical University
2015-2023
Changzhou No.2 People's Hospital
2020-2023
Suzhou Municipal Hospital
2022
Heidelberg University
2022
Wuhan University
2020
Renmin Hospital of Wuhan University
2020
Union Hospital
2020
Huazhong University of Science and Technology
2020
Abstract Children treated for medulloblastoma (MB) exhibit long-term impairments in declarative memory, but the pathophysiology underlying this is unclear. Previous studies report declines global white matter volume, have failed to link memory performance. We examined effects of treatment on measures brain structure (i.e., total and gray volume) specific structures hippocampus uncinate fasciculus). used volumetric MRI diffusion tensor imaging pediatric survivors MB one survivor astrocytoma...
Little is known about cognition and predictors of neuropsychological outcomes in pediatric low-grade glioma (PLGG) survivors treated without radiation therapy. This research expands upon our previous work by further identifying the cognitive profile PLGG patients therapy, investigating specific medical demographic variables that predict functioning, examining white matter structure its relationship to performance.Nineteen (11-19 years) were administered Wechsler Intelligence Scale for...
Objective: To investigate the predictive value of prognosis primary GBM patients using TMT on three-dimensional (3D) MR images brain. Methods: Data 130 with from TCGA-GBM database were analyzed retrospectively. was measured axial plane by multi-planar reformation (MPR) T1WI perpendicular to long axis temporal muscle at level orbital roof. The oriented parallel anterior commissure-posterior commissure line. Student᾽s t-test or Mann-Whitney U test utilized determine whether there significant...
As a primary brain cancer, glioma presents significant challenges in treatment and prognosis. Identifying reliable biomarkers is crucial for improving patient outcomes. This study focuses on the ABCC3 gene, exploring its function as standalone predictive indictor correlation with immune infiltration resistance to chemotherapy glioma. A multi-faceted approach was adopted this analysis. We scrutinized RNA expression patterns of gene across spectrum cancer types, concentrated focus Our...
Abstract Purpose: To date, there are no systemic treatment options for patients with recurrent or refractory meningioma. Experimental Design: identify effective drugs, we performed a large-scale drug screening using FDA-approved drugs on several meningioma cell lines. The impact of the top four compounds was assessed viability, proliferation, colony formation, migration, and apoptosis. In addition, antineoplastic effects selected were validated in heterotopic xenograft mouse model. Results:...
The neutrophil-to-lymphocyte ratio (NLR) is an independent predictor of clinical outcome different diseases, such as acute ischemic stroke, intracerebral hemorrhage, malignant tumor, and traumatic brain injury. However, the prognostic value NLR plus admission Glasgow Coma Scale score (NLR-GCS) still unclear in patients with diffuse axonal injury (DAI). Therefore this study assessed relationship between NLR-GCS 6-month DAI patients.The characteristics admitted to our department January 2014...
One patient with rifampin-resistant tuberculosis underwent emergency left pneumonectomy and thoracic gauze packing for hemoptysis due to recurrent after transcatheter arterial embolization. Vital signs were maintained by mechanical ventilation medication. Tracheotomy anti-tuberculosis treatment performed. After half a year of follow-up, the patient's condition was stable.
Although patients with lower-grade gliomas (LGGs; grades II and III) have a relatively favorable prognosis, frequently relapse tend to progress higher-grade gliomas, leading treatment resistance, poor survival, ultimately failure. However, until now, thorough research has not yet been reported on the relationship between PD-L2 immune infiltration therapeutic sensitivity immunotherapy TMZ-based chemotherapy of LGGs. In this study, we found that expression is upregulated in glioma, high...
Lower-grade gliomas (LGGs) have a good prognosis with wide range of overall survival (OS) outcomes. An accurate prognostic system can better predict time. RNA-Sequencing (RNA-seq) signature showed predictive power than clinical predictor models. A constructed using gene pairs transcend changes from biological heterogeneity, technical biases, and different measurement platforms. RNA-seq coupled corresponding information were extracted The Cancer Genome Atlas (TCGA) the Chinese Glioma (CGGA)....
Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. exhibit cytotoxicity have been approved by the FDA treat multiple hematological malignancies, such as hairy cell leukemia cutaneous T-cell lymphoma. However, most of internalized immunotoxin is degraded in lysosomes, only approximately 5% free toxin escapes cytosol cytotoxicity. Many studies improved immunotoxins engineering fragment reduce...
Candida albicans is the most frequently isolated opportunistic fungal pathogen in humans. However, patients with cervical lymphadenitis caused by infection are rarely reported, and few studies have focused on mechanisms underlying chronic infection. In this study, we a C. strain (JL01) from recurrent patient. The clinical isolate was identified morphological observation confirmed DNA sequencing of internal transcribed spacer (ITS) regions. Strain JL01 resistant to azole antifungal drugs, but...
Diffuse Intrinsic Pontine Glioma (DIPG) remains to be a lethal type of pediatric brain tumor date, indicating an urgent need finding novel therapeutic strategy. Through screening collection anti-tumor agents against patient-derived DIPG primary cell line, we identified few candidates for treating DIPG, among which BIRC5 inhibitor YM155 was the top potent agent. Next, confirmed that could selectively inhibit multiple lines with IC50 less than 10nM. Moreover, our gene expression analyses...
NIP patients (n = 106) admitted between January 2020 and March 2021 were selected grouped as follows according to the random number table method: a dissection group treated with dynamical-system surgery under nasal endoscope an ablation LTPRA. The clinical curative effects of two procedures compared, related indexes (operation time (OT), intraoperative blood loss (IBL), length stay (LOS)) postoperative adverse reactions (ARs) counted. In addition, fasting venous samples collected before...
Abstract Background : Lower grade gliomas (LGGs) with codeletion of chromosomal arms 1p and 19q (1p/19 codeletion) has a favorable outcome. However, its overall survival (OS) varies. Here, we established an immune signature associated 1p/19q for accurate prediction prognosis LGGs. Methods We extracted RNA sequencing corresponding clinical data LGGs from the Chinese Glioma Genome Atlas (CGGA) The Cancer (TCGA). CGGA TCGA databases were dichotomized into training group testing group....
Objective To improve the recognition for infantile spinal muscular atrophy (SMA-I) and level of early diagnosis, intervention treatment SMA-I. Methods The clinical data 39 patients with SMA-I were analyzed retrospectively, including manifestations, neural electrophysiological characteristics, genotype, prognosis SMA-I. Results Of cases , 37 cases(94.9%) had onset in 6 months after birth.The paralyses limbs symmetrical flaccid.The lower was more severe than upper proximal distal,...
A 76-year-old female patient complained of right chest pain for three months. CT scan showed a clump-like high-density shadow measuring 4.8 cm × 3.0 in size the dorsal portion lower lobe lung. Aspiration biopsy was performed, and samples were subjected to fungal culture histopathological examination. Histopathological examination chronic granulomatous inflammation with hyaline septate hyphae. After 4-day culture, white villous dense colonies formed on Sabouraud′ s agar medium. The center...
<div>AbstractPurpose:<p>To date, there are no systemic treatment options for patients with recurrent or refractory meningioma.</p>Experimental Design:<p>To identify effective drugs, we performed a large-scale drug screening using FDA-approved drugs on several meningioma cell lines. The impact of the top four compounds was assessed viability, proliferation, colony formation, migration, and apoptosis. In addition, antineoplastic effects selected were validated in...
The albumin/fibrinogen ratio (AFR) is an independent predictor of clinical outcomes some diseases; however, the prognostic value AFR and admission Hunt-Hess (HH) score still unclear for patients with aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to assess relationship between AFR-HH 6-month aSAH patients.
<p>Supplementary Figure Legends</p>
<div>AbstractPurpose:<p>To date, there are no systemic treatment options for patients with recurrent or refractory meningioma.</p>Experimental Design:<p>To identify effective drugs, we performed a large-scale drug screening using FDA-approved drugs on several meningioma cell lines. The impact of the top four compounds was assessed viability, proliferation, colony formation, migration, and apoptosis. In addition, antineoplastic effects selected were validated in...
<p>Supplementary Figures</p>