A5082996108- Influenza Virus Research Studies
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
- Mosquito-borne diseases and control
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- interferon and immune responses
- HIV Research and Treatment
- Immune Response and Inflammation
- Synthesis and Characterization of Heterocyclic Compounds
- Viral Infections and Immunology Research
- Synthesis and biological activity
- Plant Virus Research Studies
- Hepatitis B Virus Studies
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
Utah State University
2012-2023
Sarepta Therapeutics (United States)
1993-2009
University of Georgia
2008
Soroka Medical Center
2007
United States Army Medical Research Institute of Infectious Diseases
2001
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT9-(1,3-Dihydroxy-2-propoxymethyl)guanine: a new potent and selective antiherpes agentJohn C. Martin, Charles A. Dvorak, Donald F. Smee, Thomas R. Matthews, Julien P. H. VerheydenCite this: J. Med. Chem. 1983, 26, 5, 759–761Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 1983https://pubs.acs.org/doi/10.1021/jm00359a023https://doi.org/10.1021/jm00359a023research-articleACS PublicationsRequest...
ABSTRACT Influenza is a highly infectious disease characterized by recurrent annual epidemics and unpredictable major worldwide pandemics. Rapid spread of the pathogenic avian H5N1 strain escalating human infections virus have set off alarm for global pandemic. To provide an urgently needed alternative treatment modality influenza, we generated recombinant fusion protein composed sialidase catalytic domain derived from Actinomyces viscosus fused with cell surface-anchoring sequence. The to...
The efficacy of cidofovir for treatment cowpox virus infection in BALB/c mice was investigated an effort to evaluate new therapies virulent orthopoxvirus infections the respiratory tract a small animal model. Exposure 2–5 × 106 pfu by aerosol or intranasally (inl) lethal 3- 7-week-old animals. One inoculation 100 mg/kg on day 0, 2, 4, with respect infection, resulted 90%–100% survival. Treatment 0 reduced peak pulmonary titers 10- 100-fold, severity viral pneumonitis, and prevented...
The rapid emergence and subsequent spread of the novel 2009 Influenza A/H1N1 virus (2009 H1N1) has prompted World Health Organization to declare first pandemic 21st century, highlighting threat influenza public health healthcare systems. Widespread resistance both classes antivirals (adamantanes neuraminidase inhibitors) occurs in seasonal viruses, rendering these drugs be marginal utility treatment modality. Worldwide, virtually all H1N1 H3N2 strains are resistant adamantanes (rimantadine...
Arbidol (ARB) is a synthetic antiviral originally developed to combat influenza viruses. ARB currently used clinically in several countries but not North America. We have previously shown that inhibits vitro hepatitis C virus (HCV) by blocking HCV entry and replication. In this report, we expand the list of viruses are inhibited demonstrate suppresses infection mammalian cells with Ebola (EBOV), Tacaribe arenavirus, human herpesvirus 8 (HHV-8). also confirm suppression B poliovirus ARB. EBOV...
ABSTRACT The hepatitis C virus (HCV) NS5B RNA polymerase facilitates the synthesis step during HCV replication cycle. Nucleoside analogs targeting provide an attractive approach to treating infections because of their high barrier resistance and pan-genotype activity. PSI-7851, a pronucleotide β- d -2′-deoxy-2′-fluoro-2′- -methyluridine-5′-monophosphate, is highly active nucleotide analog inhibitor for which phase 1b multiple ascending dose study genotype 1-infected individuals was recently...
An improved sulfenylation method for the preparation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines from diketopiperazines has been developed. Employing NaHMDS related bases elemental sulfur or bis[bis(trimethylsilyl)amino]trisulfide (23) in THF, developed was applied to synthesis a series natural designed molecules, including epicoccin G (1), 8,8'-epi-ent-rostratin B (2), gliotoxin (3), (4), emethallicin E (5), haematocin (6). Biological screening selected synthesized...
Significance There is a pressing need for new antiinfluenza therapeutic agents. We show that molecularly engineered banana lectin (carbohydrate-binding protein) has broad-spectrum activity against all influenza strains tested, including drug-resistant and currently circulating strains; safe upon repeated administration in mice; and, moreover, efficacious at treating lethal infection via clinically pertinent routes of administration. demonstrate the binds to viral hemagglutinin glycoprotein...
ABSTRACT The novel antiviral protein cyanovirin-N (CV-N) was initially discovered based on its potent activity against the human immunodeficiency virus (HIV). Subsequent studies identified HIV envelope glycoproteins gp120 and gp41 as molecular targets of CV-N. More recently, mechanistic have shown that certain high-mannose oligosaccharides (oligomannose-8 oligomannose-9) found comprise specific sites to which CV-N binds. Such selective, carbohydrate-dependent interactions may account, at...
ABSTRACT A novel series of cyclopentane derivatives have been found to exhibit potent and selective inhibitory effects on influenza virus neuraminidase. These compounds, designated RWJ-270201, BCX-1827, BCX-1898, BCX-1923, were tested in parallel with zanamivir oseltamivir carboxylate against a spectrum (H1N1, H3N2, H5N1) B viruses MDCK cells. Inhibition viral cytopathic effect ascertained visually by neutral red dye uptake was used, 50% effective (virus-inhibitory) concentrations (EC 50 )...
T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) was inhibitory to four strains of avian H5N1 influenza virus in MDCK cells, with the 90% effective concentrations ranging from 1.3 7.7 microM, as determined by a yield reduction assay. The efficacy less than that exerted oseltamivir carboxylate or zanamivir but greater ribavirin. Experiments mice lethally infected A/Duck/MN/1525/81 (H5N1) showed administered per os once, twice, times daily for 5 days beginning 1 h after exposure highly...
We evaluated two types of compounds for efficacy in inhibiting SARSCoV replication vitro: calpain inhibitors (a class cellular cysteine proteinases) and a number nucleoside analogues. Cytopathic effect reduction assays visually determined with spectrophotometric verification by neutral red (NR) uptake assay were used to evaluate cytotoxicity antiviral potency the compounds. Significantly inhibitory then virus yield assays. Two inhibitors, Val-Leu-CHO (calpain inhibitor VI) Z-Val-Phe-Ala-CHO...
ABSTRACT Treatment with the nucleoside analog T-1106 was previously shown to be effective in a hamster model of yellow fever virus (YFV) disease, even though it had only slight activity cell culture. In study described this report, T-705, chemically related compound currently undergoing clinical trials for treatment influenza (FDANews 4:1, 2007), tested against YFV culture and model. The antiviral efficacy T-705 occurred at concentration 330 μM, which more than threefold lower efficacy, as...
ABSTRACT Cidofovir {[( S )-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] [HPMPC]}-resistant forms of camelpox, cowpox, monkeypox, and vaccinia viruses were developed by prolonged passage in Vero 76 cells the presence drug. Eight- to 27-fold-higher concentrations cidofovir required inhibit resistant than needed wild-type (WT) viruses. Resistant characterized determining their cross-resistance other antiviral compounds, examining different replication abilities two cell lines, studying...
The activities of the purine acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) against two human and five animal strains cytomegalovirus were compared with those acyclovir. DHPG was significantly more active than acyclovir all but one (mouse cytomegalovirus) tested, 50% effective doses ranging from 5 to 13 microM, as determined by plaque reduction assays in embryonic lung (MRC-5) tonsil cells. Both inhibited virus replication at concentrations considerably lower necessary...
The recurring emergence of influenza virus strains that are resistant to available antiviral medications has become a global health concern, especially in light the potential for new pandemic. Currently, virtually all circulating A United States either two major classes anti-influenza drugs (adamantanes and neuraminidase inhibitors). Thus, therapeutic approaches can be rapidly deployed will address issue resistance should developed. We have tested double triple combinations approved...
Background Lassa and Junín viruses are the most prominent members of Arenaviridae family that cause viral hemorrhagic fever syndromes Argentine fever, respectively. At present, ribavirin is only antiviral drug indicated for use in treatment these diseases, but because its limited efficacy advanced cases disease toxicity, safer more effective antivirals needed. Methodology/Principal Findings Here, we used a model acute arenaviral infection outbred guinea pigs based on challenge with an...