A5031629673- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Lipid Membrane Structure and Behavior
- Toxin Mechanisms and Immunotoxins
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- RNA Interference and Gene Delivery
- Hair Growth and Disorders
- Nanofabrication and Lithography Techniques
- Botulinum Toxin and Related Neurological Disorders
- Nanoplatforms for cancer theranostics
- Protein Interaction Studies and Fluorescence Analysis
- Immune cells in cancer
- Pediatric Pain Management Techniques
- Nanoparticle-Based Drug Delivery
- Advanced Fluorescence Microscopy Techniques
- Cancer Immunotherapy and Biomarkers
- Tea Polyphenols and Effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pain Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
Hanyang University
2021-2025
Yonsei University
2015-2020
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays superimposed onto patches facilitate their insertion into skin. However, due to wide variations skin elasticity and the amount of hair on skin, fabricated patch often not completely inserted large loaded materials delivered. Here, we report "Microlancer", novel micropillar based system by which patients can self-administer DMNs would also be...
Abstract Advancements in micro‐resolution 3D printers have significantly facilitated the development of highly complex mass‐producible drug delivery platforms. Conventionally, due to limitations micro‐milling machineries, dissolvable microneedles (MNs) are mainly fabricated cone‐shaped geometry with limited accuracy. Herein, overcome conventional MNs, a novel projection micro‐stereolithography printer‐based self‐locking MN for precise skin insertion, adhesion, and transcutaneous microdose is...
Abstract Advancements in gene delivery systems are pivotal for gene‐based therapeutics oncological, inflammatory, and infectious diseases. This study delineates the design of a self‐assembled oligopeptoplex (SA‐OP) optimized shRNA to adipocytes, targeting obesity associated metabolic syndromes. Conventional face challenges, including instability due electrostatic interactions between genetic materials cationic oligopeptides. Additionally, repeated injections induce discomfort compromise...
Polymeric microstructures encapsulating biopharmaceutics must be fabricated in a controlled environment to preserve the biological activity. There is increasing demand for simple methods designed activity by utilizing natural properties of polymers. Here, paper shows that centrifugal lithography (CL) can used fabrication such single centrifugation, engineering self-shaping hyaluronic acid (HA). In this method, HA drops are self-shaped into hourglass-microstructures produce two dissolving...
Microneedles are emerging drug delivery methods for painless treatment. The current study tested dissolving microneedles containing lidocaine (Li-DMN) use in local anesthesia. An Li-DMN patch was fabricated by centrifugal lithography with carboxymethyl cellulose as a structural polymer and assessed physical properties optical microscopy fracture force analyzer. biocompatibility evaluated histology section vitro ear thickness vivo. efficacy of the electrophysiological recordings primary...
Abstract The interest in safe and efficient transdermal drug delivery systems has been increasing recent decades. In light of that, polymeric dissolving microneedles (DMNs) were developed as an ideal platform capable delivering micro- macro-biomolecules across the skin a minimally invasive manner. A vast majority studies, however, suggest that shape DMNs, well elastic properties skin, affects efficiency materials encapsulated within DMNs. Likewise, dynamic tissues, DMNs would easily distend...
The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, elastic properties skin prevent DMNs from complete insertion accurate encapsulated compounds Moreover, adhesive materials used in patches may cause irritation, inflammation, redness. Therefore, we developed patchless, micro-pillar integrated DMN (P-DMN) that simple to...
The emergence of cancer immunotherapies, notably immune checkpoint inhibitors, has revolutionized anti-cancer treatments. These treatments, however, have been reported to be effective in a limited range cancers and cause immune-related adverse effects. Thus, for broader applicability enhanced responsiveness solid tumor immunotherapy, immunomodulation the microenvironment is crucial. Transforming growth factor-β (TGF-β) implicated reducing immunotherapy by promoting M2-type differentiation...
Abstract Dissolving microneedles (DMNs) have been widely studied in medical applications due to their pain‐free administration, superior efficiency, and safe drug delivery. In skin vaccination, preserving the activity of encapsulated antigen is an important consideration, as lost during DMN fabrication because various stress factors. These factors vary between methods each method affects antigen's different degrees. this study, antigens delivered by DMNs compared two recently developed...
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the into body. However, because of limited loading capacity within microsized structures, only small dosage can be delivered, often insufficient for patients. We propose novel DMN application that combines topical simultaneously improve permeation efficiency. Drugs pretreated formulation patch...
Abstract Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics DMNs is an efficacious approach; however, importance evaluating activity compounds, during fabrication process, has not been examined detail. Conducting analysis thermal, chemical, physical stress factors, including temperature, pH, interaction polymer mixture...
Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because incomplete insertion caused by stiffness elastic properties skin. Therefore, micropillar integrated overcome limitations DMN patches. Although micropillars designed applicators implant across skin, they can also become inserted into...
Clinical translation of current cancer vaccine research has been hampered by limited antitumor immune responses due to inefficient antigen delivery and presentation, suboptimal DC T cell activation. Biomaterial-based nanovaccine offers targeted delivery, protection from degradation in vivo, prolonged tumor therapeutic efficacy. This study introduces a lipid-coated deoxycholic acid-survivin nanoassembly (DA-L-DSA). Survivin, overexpressed several cells involved growth evasion, is selected as...
Subcutaneous (SC) insulin injection has been demonstrated to be the most effective method for treatment of diabetes mellitus but is conventionally performed by hypodermic needles, leading poor management because pain, needle phobia, and tissue trauma. Identification a viable, safe, pain-free alternative longstanding challenge in modern health care. Here, thermoplastic droplet stretching technique developed create an ultrahigh-aspect-ratio mold with simple microstructure control. The...
Abstract Metallic hollow microneedles (MHMs) are an ideal alternative to traditional insulin pen needles for innocuous self‐administration of into the subcutaneous layer. Nonetheless, MHMs present a number challenges, including restricted use biocompatible materials, biohazard issues, and limitations scale‐up fabrication. Here, novel MHM‐manufacturing technology that creates high‐aspect‐ratio microstructure by simple centrifugation is proposed. Instead thermoplastics, polyvinylpyrrolidone...
Drug Delivery In article number 2209966, Shayan Fakhraei Lahiji, Yong-Hee Kim, and co-workers introduce a novel projection micro-stereolithography 3D-printing-based self-locking microneedle platform for precise transcutaneous microdose drug delivery. The minimally invasive geometry, economical mass-producibility, improved delivery accuracy of microneedles highlight their potential as an alternative to conventional microneedles, oral administration, hypodermic injections in the near future.