A5003078392- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Lipid Membrane Structure and Behavior
- Ocular Surface and Contact Lens
- Microfluidic and Capillary Electrophoresis Applications
- Venous Thromboembolism Diagnosis and Management
- Toxin Mechanisms and Immunotoxins
- Atrial Fibrillation Management and Outcomes
- Molecular Communication and Nanonetworks
- Blood Coagulation and Thrombosis Mechanisms
- Skin and Cellular Biology Research
- Neuroscience and Neural Engineering
- Wireless Body Area Networks
- Wound Healing and Treatments
- Photonic Crystals and Applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Polydiacetylene-based materials and applications
- Hair Growth and Disorders
- Contact Dermatitis and Allergies
- Tea Polyphenols and Effects
- Bee Products Chemical Analysis
- Digital Imaging for Blood Diseases
- Hemophilia Treatment and Research
- Clinical Laboratory Practices and Quality Control
- Advanced Drug Delivery Systems
University College Dublin
2018-2019
Yonsei University
2012-2018
Abstract We present a simple and customizable microneedle mold fabrication technique using low-cost desktop SLA 3D printer. As opposed to conventional methods, this neither requires complex expensive manufacturing facilities nor expertise in microfabrication. While most 3D-printed microneedles date display low aspect ratios poor tip sharpness, we show that by introducing two-step “Print & Fill” method, it is possible obtain high-aspect ratio sharp needles are capable of penetrating...
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays superimposed onto patches facilitate their insertion into skin. However, due to wide variations skin elasticity and the amount of hair on skin, fabricated patch often not completely inserted large loaded materials delivered. Here, we report "Microlancer", novel micropillar based system by which patients can self-administer DMNs would also be...
Background: Direct oral anticoagulants (DOACs) cause unwanted interference in various hemostasis assays, including lupus anticoagulant (LA) testing, where false positive and negative identification may occur. DOAC Stop (DS) is an activated charcoal (AC) product used to specifically effectively adsorb DOACs from test plasma. This process normally requires plasma treatment, centrifugation separation prior tests, but inexperienced operators also inadvertently transfer residual AC particles,...
Blood is the gold standard sample medium that can provide a wide variety of useful biological information for diagnosis various diseases. For portable point-of-care diagnosis, blood extraction systems have attracted attention as easier, safer, and more rapid methods collecting small volumes. In this paper, we introduce novel self-powered one-touch system created by assembling smart polymer-capped hollow microneedle in pre-vacuum polydimethylsiloxane actuator. The optimized was precisely...
A minimally invasive blood-extraction system is fabricated by the integration of an elastic self-recovery actuator and ultrahigh-aspect-ratio microneedle. The simple converts finger force to energy provide power for blood extraction transport without requiring external source power. This device has potential utility in biomedical field within framework complete micro-electromechanical systems.
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the into body. However, because of limited loading capacity within microsized structures, only small dosage can be delivered, often insufficient for patients. We propose novel DMN application that combines topical simultaneously improve permeation efficiency. Drugs pretreated formulation patch...