A5100718491- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Anomalies
- Pituitary Gland Disorders and Treatments
- BRCA gene mutations in cancer
- Radiation Dose and Imaging
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Cardiovascular Disease and Adiposity
- Glaucoma and retinal disorders
- Biomarkers in Disease Mechanisms
- Vitamin D Research Studies
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Korean Urban and Social Studies
- Carbon Nanotubes in Composites
- Sympathectomy and Hyperhidrosis Treatments
- Nanotechnology research and applications
- Ophthalmology and Eye Disorders
Pusan National University Hospital
2018-2025
Pusan National University
2023-2025
Biomedical Research Institute
2020-2024
Asan Medical Center
2015-2024
Ulsan College
2015-2024
University of Ulsan
2015-2024
Pusan National University Yangsan Hospital
2024
Amorepacific (South Korea)
2023-2024
University of Pennsylvania
2008-2023
Jeju National University
2023
Papillary thyroid microcarcinoma (PTMC) usually has an excellent prognosis.To evaluate the three-dimensional structures of PTMCs, using serial neck ultrasonography (US) in patients under active surveillance.A retrospective cohort study.In total, 192 diagnosed with PTMC surveillance for >1 year were included a median 30-month follow-up. Changes tumor size evaluated not only maximal diameter but also volume.The age was 51.3 years and 145 (76%) female. The initial volume 5.5 mm 48.8 mm3,...
Purpose: Drugs that blockade interaction between programmed cell-death protein 1 (PD-1) and its ligand (PD-L1) are promising. Immune-related adverse events (irAEs) might be associated with favorable clinical outcomes, thyroid dysfunction is one of the most common irAE. We evaluated association during PD-1 treatment efficacy in patients non-small cell lung cancer (NSCLC).Experimental Design: A total 58 stage IV NSCLC treated were enrolled. Patients categorized into euthyroid groups. Overall...
Objective: To evaluate the efficacy and prognostic validity for disease-specific survival (DSS) of eighth edition American Joint Committee on Cancer/Union International Cancer Control tumor-node-metastasis (TNM) staging system (TNM-8) compared to seventh (TNM-7) in patients with differentiated thyroid carcinoma (DTC). Methods: The editions TNM were applied 1613 DTC who underwent surgery between 1996 2003. proportion variation explained Harrell's c-index evaluated compare predictive...
To investigate the glaucoma diagnostic abilities of vessel density parameters as determined by optical coherence tomography (OCT) angiography in different stages glaucoma.A total 113 healthy eyes and 140 glaucomatous were enrolled. Diagnostic OCT optic nerve head (ONH), peripapillary, macular regions evaluated calculating area under receiver operation characteristic curves (AUCs). AUCs peripapillary circumpapillary retinal fiber layer (RNFL) thickness compared.OCT densities ONH,...
Objective Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in cancer recent decades. We compared clinical outcomes and surgical complications lobectomy total thyroidectomy (TT) PTMC patients. Design methods In this retrospective individual risk factor-matched cohort study, 2031 patients with were initially included. Patients who underwent or TT one-to-one matched according to factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality...
Background: Large-volume lymph node metastasis (LNM) is associated with poor clinical outcomes in papillary thyroid microcarcinoma (PTMC) patients. However, sensitivity the detection of central neck LNM on preoperative ultrasonography (US) believed to be low. The aim this study investigate factors large-volume N0 PTMC Methods: In all, 2329 patients who underwent total thyroidectomy prophylactic (LN) dissection were evaluated. status these was divided into three groups by number metastatic...
Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management these low DTCs. The aim this study was to validate a new dynamic (DRS) system prediction structural recurrent/persistent in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy.This historical cohort included 357 lobectomy or total thyroidectomy RAI therapy. We stratified patient response initial treatment as...
Lobectomy is preferred in thyroid cancer to decrease surgical complications and avoid lifelong thyroid-hormone replacement. However, postoperative hypothyroidism, requiring replacement, may occur. We aimed identify the incidence risk factors of hypothyroidism develop a surveillance strategy after lobectomy for papillary microcarcinoma (PTMC). This historical cohort study involved 335 patients with PTMC treated by lobectomy. Postoperative functions were measured regularly, prescribed...
Background: Sorafenib and lenvatinib have been widely adopted to treat radioactive iodine (RAI)-refractory differentiated thyroid carcinoma (DTC). However, limited data exist regarding a direct comparison of these tyrosine kinase inhibitors (TKIs). We aimed evaluate the clinical efficacy safety two TKIs as first-line therapy in patients with distant metastatic or locally advanced, progressive, RAI-refractory DTC real-world practice. Methods: In this multicenter, retrospective cohort study,...
Young Joo Park, Eun Kyung Lee, Shin Song, Bon Seok Koo, Hyungju Kwon, Keunyoung Kim, Mijin Bo Hyun Won Gu Bae Woong Jung-Han Hee Na, Je Moon, Jung-Eun Sohyun Jun-Ook Ji-In Bang, Kyorim Back, Youngduk Seo, Dong Yeob Shin, Su-Jin Hwa Ahn, So Oh, Seung Hoon Woo, Ho-Ryun Won, Chang Hwan Ryu, Jee Yoon, Ka Yi, Min Kyoung Sang-Woo Sihoon Ah Joon-Hyop Ji Ye Jieun Cho Rok Dong-Jun Lim, Jae-Yol Yun Jeon, Kyong Yeun Jung, Ari Chong, Jae Chung, Chan Kwon Kwanhoon Jo, Yoon Cho, A Ram Hong, Chae Moon...
Summary Objectives Papillary thyroid microcarcinoma ( PTMC ) has an excellent prognosis with indolent disease course. However, some s have aggressive course lateral cervical lymph node LCLN metastasis or distant metastasis. This study aimed to evaluate the pre‐operative features of associated Design and Patients retrospective cohort a nested, matched case–control design included 199 patients at initial surgery (N1b group) 196 without any LN persistent (N0 NED as controls; primary tumour...
Background: Thyrotropin (TSH) suppression has improved the clinical outcomes of patients with differentiated thyroid cancer (DTC). However, efficacy TSH suppressive therapy (TST) is unclear in low-risk DTC. This study aimed to evaluate TST and optimal levels Methods: retrospective propensity score–matched cohort included DTC (n = 446) who underwent lobectomy from 2002 2008 or without (TST group No-TST group). Disease-free survival (DFS) dynamic risk stratification were compared between both...
Age >45 years is included as a variable in the tumor, node, metastases (TNM) staging of differentiated thyroid cancer (DTC), but higher cut-off value has been suggested to be more clinically relevant and prevent over-staging. We evaluated optimal age predict disease-specific survival (DSS) patients with DTC.This cohort study 6333 DTC who underwent surgery at two tertiary referral centres between 1996 2005. The 45 65 for prediction DSS was assessed. proportion variation explained (PVE)...
Iodine intake is associated with various thyroid diseases and serum thyrotropin (TSH) levels. The aim of this study was to investigate iodine its impact on the distribution TSH levels using nationwide data from Korea, a country known be replete.The sixth Korean National Health Nutrition Examination Survey (2013-2015) nationwide, cross-sectional survey general population. Participants were selected two-stage stratified cluster sampling population housing census data. A total 6564 participants...
Sorafenib, a multi-kinase inhibitor, is approved for the treatment of patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). This study evaluated efficacy and safety sorafenib in real-world clinical practice compared results to those DECISION trial. The features associated better outcomes after were also evaluated.This multicenter, retrospective cohort 98 progressive RAI-refractory DTC who treated six tertiary hospitals Korea. primary objective was...
Active surveillance is an option for patients with papillary thyroid microcarcinoma (PTMC). However, the long-term clinical outcomes after delayed surgery remain unclear. We compared of PTMC according to time interval between initial diagnosis and surgery.In this individual risk factor-matched cohort study, were classified into three groups delay period: ≤6 months, 6-12 months >12 months. Patients matched by age, sex, extent surgery, tumor size as measured ultrasonography (US), presence...
Background: Combination therapy with liothyronine (LT3) and levothyroxine (LT4) is used in patients persistent symptoms, despite being administered an adequate dose of LT4. LT3 may also be some thyroid cancer preparing for radioactive iodine therapy. However, there a controversy regarding the safety use, has been no definite evidence long-term Asian populations. The aim this study was to examine using Common Data Model (CDM). Methods: We conducted retrospective multicenter across four...
Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive lobectomy. The association of TSH on health-related quality life (HR-QoL) in after lobectomy is not well studied. This study aimed evaluate the effect patient HR-QoL
Background: Fibrocartilage metaplasia in tendons and ligaments is an adaptation to compression as well a pathological feature during degeneration. Medial meniscus posterior roots are unique that resist multidirectional forces, including compression. Purpose: To characterize the degeneration of medial root tears osteoarthritic knees, with emphasis on fibrocartilage calcification. Study Design: Cross-sectional study; Level evidence, 3. Methods: Samples were harvested from cadaveric specimens...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent tumor previously known as noninvasive subtype of encapsulated variant papillary carcinoma (EFVPTC). The absence BRAFV600E mutations has been considered characteristic NIFTPs. However, a recent study from Korea found that 28.6% NIFTPs harbored BRAF mutation. This evaluated and RAS in invasive EFVPTCs.This enrolled 32 patients NIFTP 48 EFVPTC. BRAF, NRAS, HRAS, KRAS were by direct sequencing...
Previous studies did not focus on the differences in extent of cervical lymph node (LN) dissection according to coexistent Hashimoto's thyroiditis (HT) patients with papillary thyroid carcinoma (PTC) and its clinical impact. We aimed determine whether extensive LN is responsible for favourable outcomes PTC HT coexistence itself has an independent protective effect regardless status.Retrospective cohort study.1369 who underwent total thyroidectomy central compartment neck...