A5102708203- Hydrogen embrittlement and corrosion behaviors in metals
- Corrosion Behavior and Inhibition
- Non-Destructive Testing Techniques
- Surface Modification and Superhydrophobicity
- Cardiac Valve Diseases and Treatments
- Concrete Corrosion and Durability
- Cardiac electrophysiology and arrhythmias
- Fatty Acid Research and Health
- Analytical Methods in Pharmaceuticals
- Material Properties and Applications
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Viral gastroenteritis research and epidemiology
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Cardiac tumors and thrombi
- SARS-CoV-2 and COVID-19 Research
- Aortic Disease and Treatment Approaches
- Antioxidant Activity and Oxidative Stress
- Material Properties and Failure Mechanisms
- Iron Metabolism and Disorders
- Viral Infections and Immunology Research
- Welding Techniques and Residual Stresses
- Virology and Viral Diseases
Toho University
2017-2024
LTT Bio-Pharma (Japan)
2023-2024
Nara Prefectural Institute of Public Health Research Center
2005-2024
Fukushima Medical University
1998-2024
Nagaoka University of Technology
2024
Saitama Prefecture
2024
Nagaoka University
2024
Tokyo Denki University
2016-2023
Gunma University
2021-2023
National Institute of Occupational Safety and Health
2006-2022
Epirubicin is widely used to treat various human tumors. However, it difficult achieve a sufficient antitumor effect because of dosage limitation prevent cardiotoxicity. We hypothesized that epirubicin-incorporating micelle would reduce cardiotoxicity and improve the effect. NC-6300 comprises epirubicin covalently bound PEG polyaspartate block copolymer through an acid-labile hydrazone bond. The conjugate forms micellar structure 40-80 nm in diameter aqueous milieu. (10, 15 mg/kg) (10 were...
Background: It is common for alcoholic patients to have excess iron accumulation in the liver, which may contribute development of liver disease (ALD). However, mechanism hepatic uptake ALD still obscure. Recently, a novel iron‐regulatory hormone hepcidin was found that suppresses absorption from small intestine and release macrophages. To elucidate contribution toward ALD, we examined whether alcohol loading affects expression both an ethanol‐fed mouse model. Methods: Serum prohepcidin...
An outbreak of gastroenteritis occurred at a kindergarten in Yokote City, Japan, between February 2006 and March 2006. Sapovirus was identified 19 26 stool specimens by reverse transcription-PCR. A high viral shedding pattern found for this strain, which shown to be antigenically distinct from other genogroups.
[Purpose] To evaluate the association between foot sole two-point discrimination and dynamic standing balance. [Participants Methods] This cross-sectional, observational study included 50 healthy adults. Participants were made to stand on a firm or foam surface with eyes open closed, center of pressure length was measured for static balance limits stability Two-point muscle strength assessed using test toe grip strength, respectively. We then analyzed sensory-motor assessment [Results]...
Background Hepatic iron overload is often seen in alcoholic liver disease (ALD). We previously reported that the expression of 4‐hydroxy‐2‐nonenal‐protein adducts, which a lipid peroxidative product and can be used as marker radical‐mediated cellular damage, was increased iron‐overloaded hepatocytes with ALD. However, mechanism hepatic ALD has not been clarified. In this study, to elucidate ALD, we immunohistochemically investigated transferrin receptor (TfR), mainly acts for uptake. Methods...
Visible light of short wavelength (blue light) may cause a photochemical injury to the retina, called photoretinitis or blue-light hazard. In this study, various sources were evaluated for These include sun, arc associated with welding and plasma cutting, molten steel, iron glass, interior furnaces, envelope discharge lamps, filament incandescent fluorescent lamps light-emitting diodes. The spectral radiance each source was measured, effective corresponding permissible exposure time per day...
Significance Human sapoviruses (HuSaV) are an important cause of diarrhea and foodborne infections worldwide. Despite the discovery HuSaVs over 40 y ago, no in vitro cell culture system has been established, limiting research on this pathogen. In study, we report successful propagation HuSaV a human duodenum line presence bile acids. Bile acids biological components intestinal tract, they recapitulate key physiologic factors present viral infection site intestine. This inexpensive,...
Findings of the available studies regarding roles branched-chain amino acids (BCAAs) and aromatic (AAAs) in hypertension are inconsistent, conflicting inconclusive. The purpose this study was to explore clarify existence any relationships individual BCAAs AAAs with adjustments for potential relevant confounders. A total 2805 healthy controls 2736 hypertensive patients were included current analysis. associations between explored by logistic regression analyses adjusted confounding variables....
It is unclear whether molnupiravir has a beneficial effect on vaccinated patients infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We here evaluated efficacy in mild-to-moderate disease 2019 (COVID-19) during surge Fukushima Prefecture, Japan. enrolled COVID-19 who were admitted to hospitals between January and April, 2022. Clinical deterioration after admission was compared users (n = 230) non-users 690) 1:3 propensity score matching....
Effects of host-cell adaptation the hemagglutinin (HA) protein were evaluated by analyses four pairs recent influenza B field isolates, each pair consisting an Madin Darby canine kidney (MDCK)- and embryonated chicken egg-derived isolates from same clinical specimen. Among examined, all MDCK-derived retained glycosylation site at amino acid 197 on HA1 molecule, whereas three lost it. Antigenic difference in HA molecule between MDCK- these was demonstrated to be associated with 197....