A5041264578- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Gout, Hyperuricemia, Uric Acid
- Signaling Pathways in Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Prenatal Screening and Diagnostics
- Diabetes Management and Research
- Assisted Reproductive Technology and Twin Pregnancy
- Cytomegalovirus and herpesvirus research
- Antimicrobial Resistance in Staphylococcus
- Dialysis and Renal Disease Management
- Pregnancy and preeclampsia studies
- Toxin Mechanisms and Immunotoxins
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Renal Diseases and Glomerulopathies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Ocular Infections and Treatments
- Birth, Development, and Health
- Cerebrospinal fluid and hydrocephalus
- Cytokine Signaling Pathways and Interactions
Nagoya University
2012-2025
Shizuoka University
2025
Fukushima Medical University
2005-2024
Aichi Medical University
2024
The University of Tokyo
2013-2022
Kyushu University
2005-2022
Fukushima Medical University Hospital
2022
Saitama Municipal Hospital
2014-2021
Aizawa Hospital
2013-2020
University of Colorado Anschutz Medical Campus
2016-2020
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases stroke. However, the risk factors for developing hypertension prehypertension remain poorly understood. We conducted retrospective cohort study using data 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found be in 2004 reexamined 2009. calculated cumulative incidences of over 5 examined factors, odds ratios (ORs) after adjustments age,...
Whether asymptomatic hyperuricemia in the absence of comorbidities increases risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify association between conditions. Subjects consisting Japanese adults 30 85 years age were enrolled at Center Preventive Medicine, St Luke's International Hospital, Tokyo, available enrollment (2004) 5-year follow-up (2009). excluded if they overweight or obese, hypertensive, diabetic, dyslipidemic,...
Objective Whether obesity without metabolic syndrome (i.e., “metabolically healthy” obesity) confers similar or less risk remains controversial. Methods A retrospective 5‐year cohort study of 9,721 Japanese subjects (48.5 ± 10.5 years, 4,160 men) was conducted in 2004 and reevaluated 5 years later. Subjects were excluded if they hypertensive diabetic receiving medications for dyslipidemia and/or gout hyperuricemia 2004. Study categorized according to baseline BMI ≥ 25 kg/m 2...
Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.
<b><i>Background:</i></b> While elevated serum uric acid level (SUA) is a recognized risk factor for chronic kidney disease, it remains unclear whether change in SUA independently associated with estimated glomerular filtration rate (eGFR) over time. Accordingly, we examined the longitudinal associations between and eGFR 5 years general Japanese population. <b><i>Methods:</i></b> This was large, single-center, retrospective 5-year cohort study...
Abstract Dendritic spines are the postsynaptic sites that receive most of excitatory synaptic inputs, and thus provide structural basis for function. Here, we describe an accurate method measurement analysis spine morphology based on structured illumination microscopy (SIM) computational geometry in cultured neurons. Surface mesh data converted from SIM images were comparable to reconstructed electron microscopic images. Dimensional reduction machine learning applied large sets enabled...
An epidemic of chronic kidney disease unknown etiology (Mesoamerican nephropathy) has emerged in hot regions Central America. We have demonstrated that dehydration associated with recurrent heat exposure causes animal models. However, the independent influence core body temperature on injury not been explored. In present study, we tested hypothesis could be accelerated by increasing external temperature. Wild-type mice were exposed to (39.5°C, 30 min, 2 times daily) or without mitochondrial...
Abstract Climate change should be of special concern for the nephrologist, as kidney has a critical role in protecting host from dehydration, but it is also favorite target heat stress and dehydration. Here we discuss how rising temperatures extreme events may affect kidney. The most severe presentation stroke, which can result electrolyte disturbance both acute chronic disease (CKD). However, lesser levels have multiple effects, including exacerbating precipitating cardiovascular subjects...
Aim of the study was to clarify relationship between metformin-induced vitamin B12 (B12) deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. Serum concentrations, homocysteine plasma levels, presence retinopathy history macroangiopathy (stroke or coronary heart disease) were analyzed without renal dysfunction (serum creatinine<115 μmol/L). Firstly, status 62 consecutive metformin-treated patients. Secondly, B12, 46 38 age- sex-matched...
Classical swine fever virus (CSFV) is the causative agent of classical (CSF), a highly contagious disease pigs. There are numerous CSFV strains that differ in virulence, resulting clinical with different degrees severity. Low-virulent and moderately virulent isolates cause mild often chronic disease, while an acute mostly lethal hemorrhagic fever. The live attenuated vaccine strain GPE(-) was produced by multiple passages ALD cells swine, bovine, guinea pig origin. With aim identifying...
Global spread and evolutionary links of an epidemic Clostridium difficile strain (PCR-ribotype 027) have been noted in recent decades. However, Japan, no outbreaks caused by type 027 reported to date. A total 120 C. isolates from patients at 15 hospitals during non-outbreak seasons between 2011 2013 as well 18 21 collected two 2010 2009, respectively, outbreak periods were examined. Among these isolates, Japan-ribotypes smz ysmz (subtype variant smz) the most predominant (39.2 %) followed...
We aimed to clarify the onset of diabetes.Data from 27,392 nondiabetic health examinees were retrospectively analyzed for a mean 5.3 years. Trajectories fasting plasma glucose (FPG), body mass index (BMI), and single point insulin sensitivity (Si) estimator (SPISE), an Si, 10 years before diagnosis prediabetes (PDM; n = 4781) or diabetes (n 1061) separately assessed by mixed effects model. Diabetes PDM diagnosed American Association definition on basis FPG glycosylated hemoglobin A1c...
Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with risk for kidney stones. We hypothesized that intake alters serum urinary components involved stone formation. analyzed a previously published randomized controlled study included 33 healthy male adults (40–65 years of age) who ingested 200 g (supplied 2-L volume 10% water) daily 2 weeks. Participants were evaluated at the Unit Nephrology Mateo Orfila Hospital Menorca....
An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers the sugarcane fields. One hypothesis is that CKD may be caused by recurrent heat stress and dehydration, potentially hyperuricemia. Accordingly, we developed a murine model injury associated with stress. In current experiment, tested whether treatment allopurinol (a xanthine oxidase inhibitor reduces serum urate) provides renal protection against dehydration. Eight-week-old male C57BL/6 mice were...
The clinical effectiveness of carbapenem and tigecycline, which are last-resort antimicrobials used to treat multidrug-resistant bacterial infections, faces challenges due emerging plasmid-borne resistance mechanisms, including the enzymatic inactivation antimicrobials. Here, we investigate report co-occurrence blaNDM-1 tet(X7) genes in an Acinetobacter towneri isolate from hospital wastewater Philippines. An A. PT23-B2 was obtained a treatment plant Tacloban, Philippines 2023. Whole-genome...
Fabry disease (FD) is a rare X-linked lysosomal storage disorder. Enzyme replacement therapies (ERT), such as agalsidase α and β, are available treatment options. While infusion-related reactions (IRRs) known to occur at the initiation of ERT owing immune responses, there limited information on IRRs during long-term ERT. We report case female patient with who developed unexpected hypotension after six years stable α, leading switch β. Continuous monitoring may be essential identify potential...
Regardless of their primary causes, progressive renal fibrosis and tubular atrophy are the main predictors progression to end-stage disease. Basigin/CD147 is a multifunctional molecule–it induces matrix metalloproteinases hyaluronan, for example–and has been implicated in organ fibrosis. However, relationship between basigin poorly studied. We investigated basigin's role using unilateral ureteral obstruction model. Basigin-deficient mice (Bsg−/−) demonstrated significantly less after surgery...
Abstract The prevalence of fatty liver disease (FLD) is increasing. To clarify risk factors for developing FLD, we analyzed a database from healthy Japanese adults who had annual medical check-ups in 2004 and reexamined 2009. We used the index (FLI) to classify participants as FLD (FLI ≥60), borderline (30≤ FLI <60), normal <30). Subjects with hepatitis B or C virus infection subjects at baseline were excluded. cumulative incidence over five years 0.65% (52/8,025) 12.9% (244/1,888),...
Obesity and metabolic syndrome are well-known risk factors for chronic kidney disease (CKD); however, less is known about the mechanism(s) by which might accelerate disease. We hypothesized that should development of it be associated with alterations in energy metabolism. studied pound mouse (which develops early due to a leptin receptor deletion) wild-type littermates compared level renal injury muscle wasting after equivalent oral adenine. Renal function, histology, biochemical analyses...
The feline infectious peritonitis virus (FIPV) is a member of the coronavirus family that causes FIP, which incurable and fatal in cats. Cyclosporin A (CsA), an immunosuppressive agent targets nuclear factor pathway activated T-cells (NF-AT) to bind cellular cyclophilins (CyP), dose-dependently inhibited FIPV replication vitro. FK506 (an immunosuppressor binds FK506-binding protein (FKBP) but not CyP) did affect replication. Neither cell growth nor viability changed presence either CsA or...