A5061168356- Amino Acid Enzymes and Metabolism
- Eosinophilic Esophagitis
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Gastric Cancer Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Diabetes and associated disorders
- Electrical Fault Detection and Protection
- High voltage insulation and dielectric phenomena
- Peripheral Nerve Disorders
- Thyroid Disorders and Treatments
- Muscle and Compartmental Disorders
- Circadian rhythm and melatonin
- Apelin-related biomedical research
- Renin-Angiotensin System Studies
- Pituitary Gland Disorders and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
Kanazawa University
2012-2024
Niigata University Medical and Dental Hospital
2021-2023
Aichi Medical University
2009-2021
Osaka Hospital
2020-2021
Sanyo (Japan)
2021
Osaka City University
2017-2019
Sumitomo Heavy Industries (Japan)
2019
Virginia Commonwealth University
2014
TEPCO (Japan)
2009-2013
Kitasato University
2004-2013
OBJECTIVES: No bowel preparation for colonoscopy achieves optimal efficacy and tolerability. Combining polyethylene glycol plus ascorbic acid (PEG-Asc) with adjuvants has been explored to enhance cleansing reduce the required volume. This study aimed evaluate whether adding 0.5 mg linaclotide 1-L PEG-Asc (1 L-PEG/AL) improves superior compared 24 senna L-PEG/AS), which we previously reported be non-inferior standard regimen of 2 L PEG-Asc. METHODS: A multicenter, endoscopist-blinded,...
Abstract: We have analyzed free chiral amino acids (aspartate and serine) in the human frontal cortex at different ontogenic stages (from 14 weeks of gestation to 101 years age) by HPLC with fluorometric detection after derivatization N‐tert ‐butyl‐oxycarbonyl‐ l ‐cysteine o ‐phthaldialdehyde. Exceptionally high levels d ‐aspartate ‐serine were demonstrated fetal gestational week 14. The ratios total corresponding also high, 0.63 0.27, respectively. concentration dramatically decreased a...
Abstract We have investigated the anatomical distribution and postnatal development of D‐aspartate D‐serine in rat brain periphery using HPLC techniques. D‐Serine was confined predominantly to throughout life. At birth, a substantial quantity observed areas. The cerebral content increased from birth week (PW) 3 remained constant thereafter, whereas cerebellar peaked at PW1. In contrast, transient emergence found almost all peripheral organs. A also seen areas cerebrum cerebellum decreased...
A matured megakaryocyte releases thousands of platelets through a drastic morphological change, proplatelet formation (PPF). The megakaryocyte/erythrocyte-specific transcription factor, p45 NF-E2, is essential for initiating PPF, but the factor regulating PPF has not been identified. Here we report that estradiol synthesized in megakaryocytes triggers PPF. We demonstrate key enzyme steroid hormone biosynthesis, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), target and rescues...
We have examined the effects of schizophrenomimetic drugs including phencyclidine (PCP) and methamphetamine (MAP) on cortical striatal dopamine (DA) metabolism using an in vivo dialysis technique rat. An acute systemic injection PCP (2.5–10 mg/kg, intraperitoneally (i.p.)) dramatically increased concentrations DA, 3,4-dihydroxy-phenylacetic acid, homovanillic acid dialysates from medial frontal cortex a dose-dependent fashion. However, i.p.) caused much lower augmentation extracellular DA...
DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all patterns are not stable. We demonstrate stimulatory signals can change the status around transcription factor binding sites and a start site activate expression of aldosterone synthase gene (CYP11B2).DNA CYP11B2 was analyzed aldosterone-producing adenomas, nonfunctioning adrenal glands compared with levels. CpG dinucleotides promoter were found hypormethylated tissues high...
Cardiovascular and cerebrovascular diseases (CCVD) are prominent mortality causes in Japan, necessitating effective preventative measures, early diagnosis, treatment to mitigate their impact. A diagnostic model was developed identify patients with ischemic heart disease (IHD), stroke, or both, using specific health examination data. Lifestyle habits affecting CCVD development were analyzed five causal inference methods. This study included 473,734 aged ≥ 40 years who underwent examinations...
An immunofluorescence study using unfixed cryostat sections of rat pituitary glands was carried out on sera from 34 patients with Hashimoto's thyroiditis, 28 Graves' disease, 10 thyroid adenoma and 50 healthy subjects. After absorption liver tissues, 19 retained reactivity to anterior cell antibodies (PCA, 55.8%). On the other hand, in cells faint detected only 2 disease (7.1%) after their aceton powder. A similar result also obtained when PCA were compared thyroiditis high titers microsomal...
Recent guidelines propose that both proton pump inhibitor (PPI) responders and nonresponders are included in eosinophilic esophagitis (EoE). Although multiple biopsies should be required to diagnose EoE because of patchy distribution esophageal eosinophils, it is unclear whether evaluate histological effectiveness PPI therapy. This study aimed determine the optimal biopsy protocol after therapy patients with EoE.Of 110 patients, 22 were enrolled. Intraepithelial eosinophils counted areas...
Helicobacter pylori is the leading cause of gastric cancer, but it still uncertain whether eradicating H. in early cancer (EGC) patients who underwent endoscopic resection can prevent metachronous (MGC). This study aimed to investigate effect eradication MGC after submucosal dissection (ESD).In this propensity-matched retrospective observational study, 770 with EGC received ESD were enrolled. The outcome was incidence MGC; compared between persistent and eradicated groups.MGC detected 27...
Background and study aims Endoscopic findings of esophageal eosinophilia sometimes localize to small areas the esophagus. A previous suggested that pathogenesis localized-type eosinophilic esophagitis (LEoE) was associated with acid reflux. However, LEoE treatment outcomes have not been studied. We aimed analyze clinical histologic significance in comparison diffuse-type (DEoE). Patients methods This included 106 patients eosinophilia. Esophageal defined as a condition where maximum number...
Chronic administration of morphine results in the development tolerance to analgesic effects and inhibition upper gastrointestinal motility but not colonic motility, resulting persistent constipation. In this study we examined effect chronic myenteric neurons from adult mouse colon. Similar ileum, distinct neuronal populations exhibiting afterhyperpolarization (AHP)-positive AHP-negative were identified Acute (3 μM) decreased number action potentials, increased threshold for potential...