A5027366297- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Apelin-related biomedical research
- Neuroendocrine Tumor Research Advances
- Renin-Angiotensin System Studies
- Electrolyte and hormonal disorders
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion Transport and Channel Regulation
- Hormonal and reproductive studies
- Atherosclerosis and Cardiovascular Diseases
- Bacteriophages and microbial interactions
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Nuclear Receptors and Signaling
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Eicosanoids and Hypertension Pharmacology
- Single-cell and spatial transcriptomics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Axial and Atropisomeric Chirality Synthesis
Kanazawa Hospital
2023-2024
Kanazawa University
2000-2024
Kanazawa University Hospital
2021-2023
Takeda (Japan)
2016-2018
Kouseiren Takaoka Hospital
2004
Tokyo University of Science
1985
Adrenal vein sampling (AVS) is essential for identifying a surgically curable form of primary aldosteronism (PA), but accurate placement the catheter technically challenging. Intraprocedural cortisol measurement can confirm catheter's position, thereby increasing AVS success rate. We developed quick assay (QCA) that uses immunochromatography and gold nanoparticles be performed either semiquantitatively or quantitatively. The was evaluated in two studies. In single-center study, PA patients...
Obstructive sleep apnea syndrome (OSAS) is often associated with metabolic disorders such as obesity and type 2 diabetes may contribute to cardiovascular events. A novel class of antidiabetic drugs, the sodium glucose cotransporter inhibitors (SGLT2i) reduce body weight (BW), although there limited data on their impact OSAS. We therefore evaluated effect SGLT2i OSAS in patients diabetes. The presented study was a retrospective design 18 (4 males, age range 39-81 yr) administrated SGLT2i....
DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all patterns are not stable. We demonstrate stimulatory signals can change the status around transcription factor binding sites and a start site activate expression of aldosterone synthase gene (CYP11B2).DNA CYP11B2 was analyzed aldosterone-producing adenomas, nonfunctioning adrenal glands compared with levels. CpG dinucleotides promoter were found hypormethylated tissues high...
Adrenal venous sampling (AVS) is essential for identifying a surgically curable form of primary aldosteronism. Adrenocorticotropic hormone (ACTH) infusion or bolus has been reported to improve the success rate AVS, although effects on lateralization and its outcomes in unilateral aldosteronism are unclear.The indices were examined cohort 2197 Japanese patients with from 28 centres who underwent AVS. Outcomes analysed 267 aldosterone-producing adenomas (APAs).ACTH loading during AVS improved...
Aim . To characterize subjects with a nonpositive insulinogenic index and longitudinally observe changes in their glucose tolerance. Subjects Methods A historical cohort study was conducted using data from the medical checkups of public school workers. Indices insulin secretion sensitivity derived oral tolerance test (OGTT) incidences diabetes impaired (IGT) were compared among subgroups different (change insulin/change over first 30 min on OGTT). Results Of 1464 nondiabetic at baseline, 72...
A competitive ELISA procedure for the detection of Escherichia coli heat stable enterotoxin (ST) with monoclonal antibody has been developed. This test is 10 times more sensitive than suckling-mouse bioassay and it specific, simple cheap. set 882 strains E. isolated from man were tested both by ST-ELISA bioassay, latter serving as reference method. Positive results in tests obtained 152 strains. The remaining gave negative tests, exception two strains, known to be ST producers, that assay,...
Journal Article Synthesis of corticosterone in the vascular wall Get access Y Takeda, Takeda 1Second Department Internal Medicine, School Kanazawa University, Japan. Search for other works by this author on: Oxford Academic Google Scholar I Miyamori, Miyamori T Yoneda, Yoneda K Iki, Iki H Hatakeyama, Hatakeyama A Blair, Blair F Hsieh, Hsieh R Endocrinology, Volume 135, Issue 5, 1 November 1994, Pages 2283–2286, https://doi.org/10.1210/endo.135.5.7956952 Published: 01 1994
Urinary excretion of 19-noraldosterone, 18. 19-dihydroxycorticosterone (18, 19(OH)2-B), 18-hydroxy-19-norcorticosterone (18-OH-19-nor-B), 18-hydroxycorticosterone (18-OH-B), 18-hydroxycortisol (18-OH-F) and aldosterone were measured in 25 patients with primary aldosteronism, 16 an aldosterone-producing adenoma 9 idiopathic hyperaldosteronism. In hyperaldosteronism, urinary 19-noraldosterone (207 +/- 51 pmol/day), 18, 19(OH)2-B (21 4.2 nmol/day) 18-OH-19-nor-B (879 213 pmol/day) levels lower...
Adrenal venous sampling (AVS) is the gold standard technique for subtype differentiation of primary aldosteronism (PA) and to obtain aldosterone cortisol measurements; however, their secretion patterns show fluctuations during day.We aimed examine effects AVS timing on results.This multicenter, retrospective, observational study included a total 753 patients who were diagnosed with PA underwent in 4 centers Japan. Among them, 504 249 morning (AM-AVS) afternoon (PM-AVS), respectively. The...
19-Noraldosterone, which was recently shown to be synthesized and produced in the human adrenal gland, possesses potent mineralocorticoid activity. 18,19-Dihydroxycorticosterone [18,19-(OH)2B], a possible precursor of 19-noraldosterone, has also been identified urine. To elucidate regulatory mechanism for these newly described steroids, we studied effect sodium restriction on urinary excretion 19-noraldosterone 18,19-(OH)2B six normal subjects. were measured by specific RIAs after...
Summary Pheochromocytoma crisis results from the sudden release of large quantities catecholamines and leads to progressive multiple organ dysfunction. Here we report a case pheochromocytoma with symptoms associated acute coronary syndrome (ACS) severe fluctuations in blood pressure (BP). A 43-year-old Japanese man hypertension (240/120 mmHg) visited general hospital for chest pain. Echocardiogram showed ST segment depression test demonstrated elevated troponin T. However, emergent...
Background: Aldosterone synthase gene, CYP11B2 is regulated by potassium and angiotensin II (Ang II). We have reported that Ang could change the DNA methylation status around transcription factor-binding sites a start site (TSS) activate expression of . Similar to II, small increases in extracellular levels also increase mRNA levels. Methods results: Adrenocortical H295R cells were treated with different doses potassium. Methylation analysis promoter region was done bisulfite sequencing....
Objective Primary aldosteronism (PA) is a major cause of secondary hypertension. The association between PA and other hormone disorders unclear. present study aimed to evaluate whether the parathyroid (PTH) value associated with subtypes or specific treatments.
A 52-year-old man with a history of hypertension was referred to our hospital due persistent abdominal pain. Abdominal palpation revealed remarkable rigidity and rebound tenderness all over the abdomen. Enhanced computed tomography demonstrated superior mesenteric artery (SMA) dissection complete obstruction at middle part SMA. Intraoperative findings showed significant necrosis in most small intestine surgical resection performed. Emergent operation is warranted once pain becomes...
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