A5101698369- Lipoproteins and Cardiovascular Health
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Eicosanoids and Hypertension Pharmacology
- thermodynamics and calorimetric analyses
- Lipid metabolism and disorders
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Liver Disease Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Fungal Plant Pathogen Control
- Aldose Reductase and Taurine
National Institute of Advanced Industrial Science and Technology
2024
University of Electro-Communications
2020-2024
Japan Society for the Promotion of Science
2023
Yokohama Rosai Hospital
2015
Kanazawa University
1982-2009
Instituto de Moléstias Cardiovasculares
2007
Futaba (Japan)
2001
Shionogi (Japan)
2001
Tohoku Medical and Pharmaceutical University
1996
Hokuriku University
1977-1995
Extra-adrenal steroid 21-hydroxylation and 11 beta-hydroxylation occur in a variety of human tissues. This study was undertaken to determine whether the rat mesenteric artery produces corticosterone demonstrate CYP11B1 mRNA vascular tissue. Isolated arteries were perfused with Krebs-Ringer solution for 4 h. The perfusate collected chromatographed reverse-phase HPLC system. fraction corresponding synthetic analyzed by mass spectrometry. concentration from adrenalectomized rats measured using...
The hemolytic activity of the thermostable direct hemolysin produced by Vibrio parahaemolyticus was inhibited a ganglioside mixture. component which not FM1 ganglioside.
A new variant of the low density lipoprotein receptor (LDLR) gene was ascertained through Southern blotting analysis LDLR genes 35 unrelated Japanese patients with heterozygous familial hypercholesterolemia (FH). This mutant had a 6 kilobase deletion which eliminated only exon 15, an that encodes O-linked sugar domain. The mutation recognized in two FH. We refer to these as 'FH-Tonami', since they were both born district Tonami. Although there is no evidence relation between families,...
Chronic endurance exercise training induces morphological and metabolic alterations including mitochondrial biogenesis in white adipose tissue (WAT) brown (BAT) rodents. A myokine called meteorin-like (Metrnl) is associated with adaptation increased blood after acute resistance exercise. However, the effects of chronic (RT), which aims to increase muscle mass strength, on WAT BAT are unclear. Therefore, we aimed clarify RT parameters plasma Metrnl concentrations. We applied electrical...
Hydrogen peroxide (H
Abstract Resistance exercise upregulates and downregulates the expression of a wide range genes in skeletal muscle. However, detailed analysis mRNA dynamics such as response rates temporal patterns transcriptome after resistance has not been performed. We aimed to clarify time‐series transcriptomics exercise. used electrical stimulation‐induced muscle contraction model (5 sets × 10 times 3 s 100‐Hz stimulation) on tibialis anterior rats measured before at 0, 1, 3, 6, 12 h contractions by RNA...
Abstract Lactate production is an important clue for understanding metabolic and signal responses to exercise but its measurement difficult. Therefore, this study aimed (1) develop a method of calculating lactate volume during based on blood concentration compare the effects between endurance training (EX) PGC-1α overexpression (OE), (2) elucidate which proteins enzymes contribute changes in due EX muscle OE, (3) relationship signaling phosphorylations involved mitochondrial biogenesis. OE...
Urinary excretion of 19-noraldosterone, 18. 19-dihydroxycorticosterone (18, 19(OH)2-B), 18-hydroxy-19-norcorticosterone (18-OH-19-nor-B), 18-hydroxycorticosterone (18-OH-B), 18-hydroxycortisol (18-OH-F) and aldosterone were measured in 25 patients with primary aldosteronism, 16 an aldosterone-producing adenoma 9 idiopathic hyperaldosteronism. In hyperaldosteronism, urinary 19-noraldosterone (207 +/- 51 pmol/day), 18, 19(OH)2-B (21 4.2 nmol/day) 18-OH-19-nor-B (879 213 pmol/day) levels lower...
Maintaining blood insulin levels is important for patients with diabetes because secretion capacity declines the development of disease. Calorie restriction (CR) effective improvement glucose tolerance, but it not clear whether CR can maintain in late stage diabetes. We examined effect on whole-body tolerance and fasting concentrations Male db/db mice were subjected to either a standard laboratory diet ad libitum 3 weeks (dbdb group) or 40% (dbdb+CR group). significantly decreased body mass...
The present study examined whether hypolipidemic therapy with a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pravastatin, influences corticosteroid metabolism in patients heterozygous familial hypercholesterolemia (FH). Urinary excretion of tetrahydrocortisone, tetrahydrocortisol, 6β-hydroxycortisol and free cortisol were determined 22 FH before after pravastatin administration (10 mg/day for 2 months). Pravastatin induced statistically significant decrease serum total...
The Watanabe Heritable Hyperlipidemic rabbit (WHHL rabbit) and the cholesterol-fed have been reported to show elevations of very low density (VLDL), intermediate (IDL), lipoproteins (LDL), a broad-beta band on agarose-gel electrophoresis.We studied lipid lipoprotein composition WHHL rabbits using ultracentrifugal analysis isoelectric focusing.The total cholesterol (TC)/triglyceride (TG) ratios VLDL, IDL, LDL in were slightly elevated, but almost normal compared with those ofcholesterolfed...
In order to evaluate the effects of aldose reductase inhibitor, ONO-2235, on short-term response human erythrocyte sorbitol hyperglycemia in vivo, eleven diet-treated Type 2 (non-insulin-dependent) diabetic patients were studied twice 75 g oral glucose tolerance tests - with and without ONO-2235 (200 mg p.o.) premedication. The concentrations increased increments blood test performed ONO-2235. administration 30 min prior load was lower than that (F = 5.782, P less 0.05). No significant...
We investigated the susceptibility of three inbred strains rats to hepatocarcinogen, N-nitrosomorpholine (NNM), establish a spontaneous metastatic model hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj were given 0.02% NNM in drinking water for 8 weeks thereafter left without any treatment. The experiment ceased at week 20, because mortality markedly increased after this time point WS/Shi rats. Liver weight was highest among examined. incidence HCC 15/15 (100%) rats, 1/16 (6%)...
Effect of metoclopramide (MCP), a dopaminergic antagonist, on orthostatic hypotension associated with diabetes mellitus, was investigated to prove its plausible role renin-angiotensin-aldosterone and catecholamine activation by comparative study in 6 diabetics (OH) 9 without OH. With MCP treatment, drop systolic blood pressure (SBP) standing significantly improved. However, the postural responses plasma renin activity (PRA), aldosterone norepinephrine were not enhanced treatment. Moreover,...
Introduction: The dynamics of reactive oxygen species (ROS) in the cytosol and mitochondria function as signaling factors that regulates diverse cellular adaptations. Hydrogen peroxide (H 2 O ) is considered one most influential ROS regulating physiological function; being a ubiquitous molecule with long half-life high diffusing capacity compared to other (e.g., superoxide hydroxyl radicals). Temperature changes within skeletal muscle myocytes constitute an environmental factor modulates...
Abstract This study aimed to determine effects of cooling on contraction‐induced peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) and vascular endothelial growth factor (VEGF) gene expression, phosphorylations its related protein kinases, metabolic responses. Male rats were separated into two groups; room temperature (RT) or ice‐treated (COLD) the right tibialis anterior (TA). The TA was contracted isometrically using nerve electrical stimulation (1‐s × 30 contractions,...