A5032748127- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Diabetes Treatment and Management
- Adrenal and Paraganglionic Tumors
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Nuclear Receptors and Signaling
- Neurological and metabolic disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Thyroid Disorders and Treatments
- Obstructive Sleep Apnea Research
- Electrolyte and hormonal disorders
- Microbial metabolism and enzyme function
- Intracranial Aneurysms: Treatment and Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- Regulation of Appetite and Obesity
- Apelin-related biomedical research
- Mast cells and histamine
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Renin-Angiotensin System Studies
Asanogawa General Hospital
2021-2025
Kanazawa University
2015-2025
Fukui Prefectural Hospital
2021-2024
Kanazawa University Hospital
2012
Adrenal vein sampling (AVS) is essential for identifying a surgically curable form of primary aldosteronism (PA), but accurate placement the catheter technically challenging. Intraprocedural cortisol measurement can confirm catheter's position, thereby increasing AVS success rate. We developed quick assay (QCA) that uses immunochromatography and gold nanoparticles be performed either semiquantitatively or quantitatively. The was evaluated in two studies. In single-center study, PA patients...
Obstructive sleep apnea syndrome (OSAS) is often associated with metabolic disorders such as obesity and type 2 diabetes may contribute to cardiovascular events. A novel class of antidiabetic drugs, the sodium glucose cotransporter inhibitors (SGLT2i) reduce body weight (BW), although there limited data on their impact OSAS. We therefore evaluated effect SGLT2i OSAS in patients diabetes. The presented study was a retrospective design 18 (4 males, age range 39-81 yr) administrated SGLT2i....
Key Clinical Message Recently, hypoxia‐inducible factor prolyl hydroxylase (HIF‐PH) inhibitors have been used for renal anemia, but side effects also reported. We report on the association of central hypothyroidism and cholesterol with roxadustat. Based this case previous reports, we believe that patients receiving roxadustat should their thyroid function levels checked regularly.
Abstract Objectives Tirzepatide belongs to a new class of anti-diabetic agents that stimulate both glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors, resulting in greater blood glucose-lowering effect body weight reduction than analogs. However, data on the effects switching from analogs tirzepatide glucose level, weight, liver functions are unavailable. Methods Data 40 patients with type 2 diabetes who received prescription change dulaglutide were...
Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the PA in general population. Therefore, we examined population including normotensive subjects.Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and ratio (ARR) were determined 309 subjects aged >40 years Horimatsu Higashi-Matsuho district, Shika-machi, Ishikawa, Japan.Among them, 195 (78 males, mean age: 62 ± 11 years) did not...
Abstract Background Plasma aldosterone-to-renin ratio (ARR) is popularly used for screening primary aldosteronism (PA). Some medications, including diuretics, are known to have an effect on ARR and cause false-negative false-positive results in PA screening. Currently, there no studies the effects of sodium–glucose cotransporter-2 (SGLT2) inhibitors, which diuretic effects, ARR. We aimed investigate SGLT2 inhibitors Methods employed a retrospective design; study was conducted from April 2016...
Experimental models recently suggested an interaction between aldosterone and adipose tissue, but clinical investigation has been limited. We studied the effects of eplerenone compared to hydrochlorothiazide (HCTZ) on blood pressure (BP), glucose, lipid levels in 50 patients with essential hypertension (EHT) type 2 diabetes mellitus whose BP failed reach target 8 mg candesartan alone. improved similarly both groups over 12-month study period, BMI, waist circumference, LDL-cholesterol were...
A man in his early 70s was admitted to our hospital with uncontrollable bilateral arm movements that had started 2 days prior the presentation. He a negative history of chorea, diabetes mellitus, and exposure manganese organic mercury. also no family chorea.
An early 30s woman with a history of bipolar disorder presented to our hospital, having abdominal pain for the previous 4 days. Her body weight had increased over years, and type 2 diabetes hypertension developed years ago. medication includes as follows: tofogliflozin 20 mg,
Nuclear receptors are involved in a wide variety of functions, including aldosteronogenesis. receptor families NR4A [nerve growth factor-induced clone B (NGFIB), Nur-related factor 1 (NURR1) and neuron-derived orphan (NOR1)] NR2F [chicken ovalbumin upstream promoter-transcription (COUP-TFI), COUP-TFII NR2F6) activate, whereas NR5A1 [steroidogenic (SF1)] represses CYP11B2 (aldosterone synthase) gene transcription. The present study was undertaken to elucidate the mechanism differential...
Summary Fulminant type 1 diabetes (FT1D) is a subtype of characterized by rapid progression β-cell destruction, hyperglycemia, and diabetic ketoacidosis (DKA). The pathogenesis this disease remains unclear. However, viral infections, HLA genes, immune checkpoint inhibitor use were reportedly involved in disease. A 51-year-old Japanese man with no chronic medical condition was admitted to our hospital complaints nausea vomiting. Cough, sore throat, nasal discharge, diarrhea not noted. He had...
Primary aldosteronism (PA) is a major cause of secondary hypertension, divided into two subtypes: unilateral and bilateral. Unilateral PA (u-PA) surgically-curable. Medical treatment with mineralocorticoid receptors antagonists recommended as second-line when the patients are not candidate for surgical treatment. The present case was 39-year-old woman u-PA, who had refused surgery, suffered from adverse effects medical She treated transcatheter adrenal arterial embolization (TAAE). Her blood...
Introduction: Individuals who have had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may develop post-coronavirus disease conditions, also known as long COVID. The symptoms of COVID are nonspecific, and there similarities between the those Graves’ (GD). Therefore, it is important to rule out GD in patients suspected having Telemedicine widely used avoid risk SARS-CoV-2 infection. However, owing lack in-person examinations, diagnostic errors can occur. Case...
Background and Objectives: Degludec (Deg) glargine U300 (Gla-300) are insulin analogs with longer smoother pharmacodynamic action than U100 (Gla-100), a long-acting that has been widely used for many years in type 1 2 diabetes. Both improve glycemic variability (GV) the frequency of hypoglycemia, unlike Gla-100. However, it is unclear which analog affects GV hypoglycemia better patients insulin-dependent We evaluated effects switching from Deg to Gla-300 on day-to-day diabetes treated...
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by polyarthritis and limb edema. Although the detailed mechanisms of this have not been clearly understood, some agents including dipeptidyl peptidase-4 inhibitors reported to induce RS3PE syndrome. However, glucagon-like peptide-1 (GLP-1) analogues be associated A 91-year-old woman was admitted our hospital complaints severe She diagnosed Oral prednisolone improved her symptoms. symptoms...
Hyperosmolar hyperglycemic syndrome (HHS) is a severe diabetes-related condition. Patients with HHS can present abnormal magnetic resonance imaging (MRI) findings similar to those of fresh cerebral infarction. Here, we the case 95-year-old woman who was initially misdiagnosed seizures due infarction pons. Her MRI revealed small lesions in bilateral pons which showed hyperintensity on T2-weighted and diffusion-weighted imaging. Thus, patient diagnosed associated However, hyperglycemia...
Low cholesterol levels are good markers for central hypothyroidism in case with dialysis using roxadustatSerina Kita1，Hiroshi Okuyama2，Takaya Kondo1，Mizuki Hayashi1，Shinichiro Nakao1，Toshitaka Sawamura2，Keiji Fujimoto1，Atsushi Nakagawa3，Hitoshi Yokoyama1，Kengo Furuichi1Department of Nephrology, Kanazawa Medical University1，Asanogawa General Hospital2，Department Diabetology and endocrinology, University3Corresponding author Kengo FuruichiKanazawa University Department Nephrology1-1 Daigaku,...
Objective: The mineralocorticoid Receptor (MR) is expressed not only in the kidneys but also adipose tissue, and primary aldosteronism (PA) associated with metabolic syndrome. This study assessed effects of aldosterone blockade on factors patients PA. Method: Sixty-five PA were treated one two MR antagonists; eplerenone (50-100 mg, daily, n=38) or spironolactone (25-50 n=27) for 14 months. Visceral (VAT) subcutaneous tissue (SAT) quantified using CT “Fat Scan” imaging analysis software. Body...
Purpose: Adrenal vein sampling (AVS) after ACTH stimulation is recommended for identifying the primary aldosteronism subtypes in Japan, but cutoff values ascertaining lateralization of aldosterone secretion remain controversial. Methods: We examined index ((1) plasma concentration (PAC)dominant/ cortisol (PCC)dominant /PACnondominant/PCCnondominant>2 before stimulation, (2) PACdominant>14000 pg/mL (3) PACdominant/PCCdominant/ PACnondominant/PCCnondominant>2.6, where “dominant” and...
The activation of local renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the overall pathophysiology cardiorenal syndrome. We have reported increased mRNA levels angiotensinogen, angiotensin converting enzyme (ACE) and CYP11B2 (aldosterone synthase gene) heart kidney salt-sensitive hypertensive rats complicated with cardiac hypertrophy renal injury. However, mechanism control gene expression each component RAAS is unknown. analyzed epigenomic alteration, which controls...