A5065075607- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Stress Responses and Cortisol
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Pancreatitis Pathology and Treatment
- Sodium Intake and Health
- Fatty Acid Research and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gut microbiota and health
- Health disparities and outcomes
- Vitamin D Research Studies
- Diet, Metabolism, and Disease
- Child Development and Digital Technology
- Musculoskeletal pain and rehabilitation
- Health and Wellbeing Research
- Folate and B Vitamins Research
- Pain Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Eating Disorders and Behaviors
- Cardiovascular Disease and Adiposity
- Asthma and respiratory diseases
- Autism Spectrum Disorder Research
- Congenital Heart Disease Studies
Kanazawa University
2016-2025
Kanazawa Medical University
2020-2024
Environmental Restoration and Conservation Agency
2024
OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) is a phenotype of type 2 diabetes and obesity. Currently, the efficacy sodium–glucose cotransporter (SGLT2) inhibitors sulfonylureas in pathology hepatic gene expression profiles for with NAFLD are unknown. RESEARCH DESIGN AND METHODS We conducted 48 week, randomized, open-label, parallel-group trial involving participants biopsy-confirmed NAFLD. A total 40 were randomly assigned to receive once daily 20 mg tofogliflozin or 0.5 glimepiride....
Only a few studies have focused on the relationship between vitamin intake and depressive symptoms in Japanese individuals. This cross-sectional study investigated 1634 elderly individuals (65 years older). The consumption of fifteen vitamins including retinol, retinol equivalent, beta-carotene D, alpha-tocopherol, K, group B, C, cryptoxanthine was analyzed using brief-type self-administered diet history questionnaire (BDHQ). short version Geriatric Depression Scale (GDS) used to assess...
The aim of this cross-sectional study was to examine the relationship mineral intake, including sodium, potassium, calcium, magnesium, phosphorus, iron, zinc, copper and manganese, with depressive symptoms in both genders Japanese elderly population. A total 1423 participants who were older than 65 years old recruited study. Mineral intake analyzed using a validated brief self-administered diet history questionnaire. Depressive assessed short version Geriatric Depression Scale. logistic...
Abstract Hyperuricemia (HUA) is a symptom of high blood uric acid (UA) levels, which causes disorders such as gout and renal urinary calculus. Prolonged HUA often associated with hypertension, atherosclerosis, diabetes mellitus, chronic kidney disease. Studies have shown that gut microbiota (GM) affect these diseases. This study aimed to determine the relationship between GM. The microbiome 224 men 254 women aged 40 years was analyzed through next-generation sequencing machine learning. We...
Background/Objectives: Macronutrients (protein, fat, and carbohydrate) provide sources of energy play crucial roles in various physiological functions. However, sex differences the relationships between protein, carbohydrate intakes all-cause mortality remain unclear. The present study investigated using longitudinal epidemiological data. Methods: A total 3743 healthy residents (1666 men 2077 women) aged 40 years or older were followed up (men: 6.64 ± 1.51 years, women: 6.76 1.28 from 2013)...
Sedentary behaviors have recently become an important public health issue. We aimed to investigate the relationship between screen time and nutrient intake in children adolescents. The present study was conducted 2013. Data were collected from adolescents aged 6 15 years old Shika town. Questionnaires distributed 1459 subjects, 1414 of whom participated (96.9%). assessed based on participants' (television (TV) viewing, personal computer (PC) use, mobile phone (MP) use). main outcomes...
Understanding the mechanisms linking steatosis to fibrosis is needed establish a promising therapy against nonalcoholic fatty liver disease (NAFLD). The aim of this study was clarify clinical features and hepatic gene expression signatures that predict contribute development during long-term real-world histological course NAFLD in subjects with without diabetes. A pathologist scored 342 serial biopsy samples from 118 clinically diagnosed 3.8-year (SD 3.45 years, maximum 15 years) treatment....
Abstract We conducted a randomized, controlled trial to examine the effects of salt‐reduction and efficacy‐maintenance program on improvement maintenance self‐care self‐efficacy in reducing salt intake older people with high blood pressure. A total 51 participants hypertension/prehypertension Indonesia were randomly assigned control group or one two intervention groups: training efficacy‐maintenance. The received educational meeting; participants' knowledge, attitudes, practices,...
Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, IL-17 and on community-dwellers are few. The purpose this study was to investigate cytokine levels, especially IL-17A, among subjects high low depressive symptoms a general population. participants comprised 20 female aged 40 years or older who contributed Shika in Ishikawa, Japan. Ten showed higher ten lower 208 females assessed by the Japanese version Centre for...
The aim of this study was to examine the relationship between hypertension and health-related quality life (HRQoL) adjusted by chronic pain, other diseases, habits in general middle-aged population Japan. This is a population-based cross-sectional study. In study, 1117 participants aged 40–65 years living Shika Town completed self-administered questionnaire including Short Form-36 (SF-36). scores SF-36 among hypertensives were compared with those normotensives. independent association each...
n-3 polyunsaturated fatty acids (PUFAs) have been shown to preventive effects against depression. In this study, we aimed investigate the associations between intake of PUFAs and depression among people according sex weight status. We utilized cross-sectional data from Shika study in Japan. The was conducted 2013 2016. Data were collected adults older than 65 years. Invitation letters distributed 2677 individuals, 2470 whom participated (92.3%). assessed depressive states using Japanese...
The relationship between dietary n-6 fatty acids and hypertension is not clear. metabolic products of include those that control blood pressure, such as prostaglandin thromboxane, differ depending on the extent glucose tolerance. This cross-sectional study investigated association acid intake hypertension, effects glycated hemoglobin (HbA1c) value in 633 Japanese subjects aged 40 years older. Dietary was measured using a validated brief self-administered diet history questionnaire. We...
The relationship among dietary calcium, hypertension and vitamin D status currently remains unclear. This population-based cross-sectional study examined the association between calcium intake influence of serum concentrations 25-hydroxyvitamin [25(OH)D] in Japanese subjects. A total 619 subjects aged from 40 years were recruited. Dietary was measured using a validated brief self-administered diet history questionnaire. Hypertension defined as use antihypertensive medication or blood...
The aim of this study was to examine potential differences the associations between mental health and lifestyle factors across a wide range age.In August/September 2011, data were collected from 4693 males (age 51.6 ± 19.5) 5678 females 52.4 19.4) living in Kanazawa, Japan. A cross-sectional community-based survey conducted with self-administered questionnaire including General Health Questionnaire (GHQ) 12-item version, sociodemographic, factors. Associations GHQ scores other variables...
Increased food selectivity among children with autism spectrum disorder (ASD) may lead to nutritional inadequacy. The present study examined differences in nutrient intake between and adolescents without ASD. We utilized cross-sectional data from the ongoing population Shika Town rural Japanese study. participants were 1276 pupils students aged 7 15 years. ASD traits evaluated using Autism Spectrum Screening Questionnaire (ASSQ). Nutrient was assessed a frequency questionnaire. A one-way...
Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing causal relationship between gut microbiota (GM) and DL. In present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate GM A total 79 men 82 women aged 40 years or older living in Shika-machi, Ishikawa Prefecture, Japan were included analysis, their clinical information was investigated. DNA extracted from processed sequence 16S rRNA gene using next-generation sequencing....
Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the PA in general population. Therefore, we examined population including normotensive subjects.Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and ratio (ARR) were determined 309 subjects aged >40 years Horimatsu Higashi-Matsuho district, Shika-machi, Ishikawa, Japan.Among them, 195 (78 males, mean age: 62 ± 11 years) did not...
Selenoprotein P is a hepatokine with antioxidative properties that eliminate physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels selenoprotein are elevated during aging and in people type 2 diabetes, non-alcoholic fatty liver disease, hepatitis C. However, how serum full-length regulated largely remains unknown, especially the general population. To understand significance population, we evaluated intrinsic environmental factors...
Abstract Background Food allergy (FA) is a common disease in children, and its prevalence has increased developed countries. The impact of overweight on children health also becomes an important social problem. However, the relationship between FA still unclear. We examined association among Japanese children. Methods analyzed data obtained using self-administered questionnaire from 1772 Weight groups according to body mass index cutoff points proposed by International Obesity Task Force...
Despite a close relationship between chronic kidney disease (CKD) and uric acid level, few studies have examined the level fat intake by function status. Therefore, we investigated association dietary hyperuricemia with without decreased in males living Shika Town, Ishikawa Prefecture, Japan. This study included 361 mean age of 60.7 years. Dietary fatty intakes were evaluated using brief-type self-administered diet history questionnaire. Reduced was defined as an estimated glomerular...
The association between heavy metals exposure and respiratory diseases or allergic sensitization showing high serum immunoglobulin E (IgE) has been suggested. However, previous findings have inconsistent the mechanisms responsible remain unclear. We evaluated metal its with coughing, itchy eyes in chronic cough patients different IgE levels. Ninety outpatients Kanazawa University Hospital were recruited January-June 2011. Subjects whose total measured by radioimmunosorbent test asked to...