Kichiya Suzuki
A5042556561- Sperm and Testicular Function
- Genetic Associations and Epidemiology
- Reproductive Biology and Fertility
- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Birth, Development, and Health
- Retinoids in leukemia and cellular processes
- Cardiovascular Disease and Adiposity
- BRCA gene mutations in cancer
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Neonatal Respiratory Health Research
- Protein Hydrolysis and Bioactive Peptides
- Metabolism and Genetic Disorders
- Gout, Hyperuricemia, Uric Acid
- Biotin and Related Studies
- Kidney Stones and Urolithiasis Treatments
- Hormonal and reproductive studies
- Cellular transport and secretion
- Sodium Intake and Health
Tohoku Medical Megabank Organization
2013-2024
Tohoku University
2013-2024
Tohoku University Hospital
2009-2020
Tokai University
2017
Vanderbilt University
2002-2012
Yamagata University
1995-2009
Abstract The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070 healthy Japanese individuals and construction a population reference panel (1KJPN). Here we identify through this high-coverage sequencing (32.4 × on average), 21.2 million, including 12 million novel, single-nucleotide variants (SNVs) at an estimated false discovery rate <1.0%. This detailed analysis detected signatures for purifying selection regulatory elements as well coding regions. We also...
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Abstract Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were in European populations. We here performed a GWAS and replication study using large Japanese cohort (9,906 cases 83,943 male controls) to identify novel susceptibility PCa risk. found 12 for including rs1125927 ( TMEM17 , P = 3.95 × 10 −16 ), rs73862213 GATA2 5.87 −23 rs77911174 ZMIZ1 5.28 −20 rs138708 SUN2 1.13 −15 seven which had crucially low...
A bstract : Previous studies from our group have shown that Foxa1 is expressed in the prostate and interacts with androgen receptor (AR) to regulate prostate‐specific genes such as antigen (PSA) probasin (PB). We report here Foxa2 but not epididymis. Further, AR mouse epididymal retinoic acid binding protein (mE‐RABP) gene, an epididymis‐specific gene. Binding of mE‐RABP promoter was confirmed by gel‐shift chromatin immunoprecipitation (ChIP) assays. Overexpression suppresses activation...
The Tohoku Medical Megabank biobank (TMM biobank) is the first major population-based established in Japan. TMM was based on two population cohorts and a reconstruction program from Great East Japan Earthquake Tsunami of 2011. stores more than 3.4 million tubes biospecimens associated health analytic data obtained approximately 150,000 cohort participants between May 2013 December 2018, currently shares high-quality specimens data. Various biospecimens, including peripheral cord blood...
Abstract We report here a novel glycosylphosphatidyl-inositol (GPI)-anchored glycoprotein on human leukocytes. Treatment of neutrophils with mAb (3H9) to this molecule sequentially up-regulates and down-regulates β2 integrin-dependent adhesion these cells as well their transendothelial migration in vitro. In addition, simultaneously modulates the avidity integrin for its ligand, iC3b, kinetics similar those observed 3H9 modulation neutrophil adherence. This also induces cytoskeletal...
In the present study, we have isolated cDNA for mouse oviduct-specific glycoprotein (MOGP) by screening oviduct library with bovine (BOGP)-cDNA probe and 5′ rapid amplification of end (5′RACE). The total length was determined to be 2525 base pairs (bp) sequence analysis. coding region contained 2163 bp translating 721 amino acids. Based on comparisons N-terminal acid sequences purified-BOGP hamster (oviductin), it inferred that derived a signal peptide 21 acids mature MOGP (core protein) 700...
Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, genetics and prospective cohort studies develop a critical infrastructure for establishment PHC. To date, TMM CommCohort (adult general population) BirThree Cohort (birth+three-generation families) have conducted recruitments baseline surveys. Genome analyses as part will aid in...
Epididymal epithelium is well known as a site of secretion various proteins present in epididymal luminal fluid. Although there have been many reports primary cultures epithelial cells, their growth limited over time. We established immortalized cell lines from cells transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene order to study the regulatory mechanisms function, including specific factor secretion. These (PC1 proximal caput; and DC1, DC2, DC3 distal...
With the goal of realizing genome-based personalized healthcare, we have developed a biobank that integrates personal health, genome, and omics data along with biospecimens donated by volunteers 150,000. Such large-scale integration involves obvious risks privacy violation. The research use genome health information is topic global discussion regard to protection while promoting scientific advancement. present paper reports on our plans, current attempts, accomplishments in addressing...
Significance Statement Although there is evidence that genetic factors may play a substantial role in the risk of urolithiasis, basis for this condition remains largely unidentified. Previous genome-wide association studies (GWAS) have identified only six gene loci as risk-related. In work, authors performed GWAS using 11,130 cases and 187,639 controls from Japanese population, identifying 14 significant associated with which nine are novel. Ten showed one or more 16 quantitative traits,...
Abstract Lung function reflects the ability of respiratory system and is utilized for assessment diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) would be improved by adjustment with an indicator inflammation. Here, we performed a GWAS exhaled nitric oxide (FeNO) levels in two independent Japanese populations. Our genotype imputations revealed that RNF5/AGER locus including AGER rs2070600 SNP, which introduces G82S substitution...
To elucidate the differences in ocular biometric parameters by generation and gender to identify axial length (AL)-associated genetic variants Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data.We designed ToMMo Study, examined AL variations, conducted genome-wide association studies (GWASs).In total, 33 483 participants aged > 18 years who were recruited into community-based cohort (CommCohort) birth three-generation (BirThree Cohort) of...
Exposure to several metallic elements has been suggested as a risk factor for gestational diabetes mellitus (GDM), but inconsistent findings have reported. This study aimed examine the association between maternal whole blood concentration of (Hg, Pb, Cd, Mn, and Se) GDM using dataset Japan Environment Children's Study (JECS), nationwide birth cohort study, which was designed adverse effects pre/post-natal exposure hazardous environment.The data 78,964 pregnant women who were participants...
The purpose of this study was to report the basic profile Miyagi Prefecture part a repeated center-based survey during second period Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well participants' characteristics based on their participation type in baseline survey.
To show whether molecular motor dynein on a microtubule track, myosin Va, recruiter VIIa-Rab27a/b interacting protein (MyRIP), and vesicle receptor Rab27b an F-actin track were present during human monkey spermiogenesis involving intramanchette transport (IMT).Spermiogenic cells obtained from three men with obstructive azoospermia normal adult cynomolgus (Macaca fascicularis). Immunocytochemical detection reverse transcription-polymerase chain reaction (RT-PCR) analysis of the proteins...
Abstract The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) have diurnal and day-to-day variations. Therefore, we investigated number of days required yield a better association between morning uNa/K home BP (HBP) determined that can used as in participants who are not taking antihypertensive medication. This was cross-sectional study using data from Tohoku Medical Megabank...
There is growing evidence that the oviduct not a passive conduit for gamete and embryo transport but serves function gametes and/or embryos. The oviductal epithelium secretes one or more specific glycoproteins associate with egg after ovulation. Several published reports including our preliminary studies have suggested egg-associating glycoprotein(s) from exists in several mammalian species golden hamster. However, little almost no biochemical characterization of hamster oviduct-specific...
Many QTL analyses related to meat production and quality traits have been carried out using an F(2) resource population produced by crossing 2 genetically different breeds. This experiment was intended investigate whether these were segregating in a purebred Duroc that had selected for during 7 generations. Sus scrofa chromosome 7, which significant of intramuscular fat many other already reported, studied. The polymorphism 10 microsatellite markers arranged at about 20-cM intervals...