A5022118501- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Effects and risks of endocrine disrupting chemicals
- Trace Elements in Health
- Child Nutrition and Water Access
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Chemical Analysis and Environmental Impact
- Urological Disorders and Treatments
- Prenatal Substance Exposure Effects
- Demographic Trends and Gender Preferences
- Pregnancy and Medication Impact
- Noise Effects and Management
- Folate and B Vitamins Research
- Infant Nutrition and Health
- Environmental Justice and Health Disparities
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Heavy metals in environment
- Chemokine receptors and signaling
- Mass Spectrometry Techniques and Applications
National Institute for Environmental Studies
2016-2025
Tohoku University
2011-2019
Yaroslavl State University
2019
Albert Einstein College of Medicine
2019
Kyorin University
2019
Japan Society for the Promotion of Science
2012-2015
The Japan Environment and Children's Study (JECS), known as Ecochil-Chosa in Japan, is a nationwide birth cohort study investigating the environmental factors that might affect children's health development. We report baseline profiles of participating mothers, fathers, their children.Fifteen Regional Centres located throughout were responsible for recruiting women early pregnancy living respective recruitment areas. Self-administered questionnaires medical records used to obtain such...
Numerous poly- and perfluoroalkyl substances (PFAS) have been manufactured distributed on the world market. Research PFAS has highlighted their global distribution impacts ecosystems human health. Following regulations public concern, production shifted toward novel molecules in recent years. New classes of identified environment are gaining worldwide attention. The development an efficient strategy for identification quantification emerging is essential risk assessment. This review presents...
The Japan Environment and Children's Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect environment on child health development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) selenium (Se) are considered be important co-exposures when examining other chemical substances levels these elements in blood 20,000 randomly selected mid/late-term pregnant women from whole JECS cohort were analysed using inductively coupled plasma-mass...
The effects of prenatal exposure to toxic elements on birth outcomes and child development have been an area concern. This study aimed assess the profile elements, arsenic (As), bismuth (Bi), cadmium (Cd), mercury (total (THg), methylmercury (MHg), inorganic (IHg)), lead (Pb), antimony (Sb) tin (Sn), essential trace copper (Cu), selenium (Se) zinc (Zn), using maternal blood, cord blood placenta in Tohoku Study Child Development Japan (N = 594–650). Inductively coupled plasma mass...
The hair-to-blood ratio and biological half-life of methylmercury in a one-compartment model seem to differ between past recent studies. To reevaluate them, 27 healthy volunteers were exposed at the provisional tolerable weekly intake (3.4 µg/kg body weight/week) for adults through fish consumption 14 weeks, followed by 15-week washout period after cessation exposure. Blood was collected every 1 or 2 hair cut 4 weeks. Total mercury (T-Hg) concentrations analyzed blood hair. T-Hg levels...
The Japan Environment and Children's Study (JECS) is a nation-wide birth cohort study investigating environmental effects on children's health development. In this study, the exposure characteristics of JECS participating mothers were summarized using two questionnaires administered during pregnancy.Women recruited early period their pregnancy. We intended to administer questionnaire first trimester (MT1) second/third (MT2). total number registered pregnancies was 103,099.The response rates...
Volatile organic compounds (VOCs) are major indoor air pollutants. Quantification of concentrations VOCs and identification factors associated with these can help manage quality. This study measured the inorganic gaseous pollutants in around 5000 households Japan utilised a random forest model to estimate identify important determinants. The homes 5017 randomly selected participants Environment Children's Study (JECS) were visited twice, when children aged 1.5 3 years. Twelve during 7 days...
Prenatal cadmium exposure has been associated with adverse neurodevelopmental outcomes. However, previous findings are contradictory, and little is known about the potential modifiers of cadmium-related risk. We investigated associations between prenatal neurodevelopment in 2-year-old children examined influence mother/child characteristics. recruited 3545 mother–child pairs from Japan Environment Children's Study. collected maternal blood during mid/late pregnancy cord at delivery, measured...
The Japan Environment and Children's Study (JECS) is a nationwide birth cohort study investigating environmental effects on children's health development. A Sub-Cohort has begun, conducting extended exposure outcome measurements by targeting subgroup randomly selected from the JECS Main Study. We report methodology participants' baseline profiles.Of 100,148 children in Study, born after April 1, 2013 who met eligibility criteria ([1] all questionnaire medical record data their mothers...
Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative urinary biomarkers. This study investigated cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in Japan Environment Children’s Study, a nationwide birth cohort study. Pregnant participants with measured (UCCs) completed on status were included (n = 89,895). The values (COVs) for active smokers calculated by fitting mixed...
Many studies have investigated the devastating health effects of heat waves, but less is known about risks related to cold spells, despite evidence that extreme may contribute a larger proportion deaths.We aimed systematically investigate association between spells and mortality in Japan.Daily data for weather conditions 12 common causes death during 1972-2015 seasons (November-March) were obtained from 47 Japanese prefectures. Cold defined as ≥2 consecutive days with daily mean temperatures...
Abstract Methylmercury selectively damages the central nervous system (CNS). The tumor necrosis factor (TNF) superfamily includes representative cytokines that participate in inflammatory response as well cell survival, and apoptosis. In this study, we found administration of methylmercury induced TNF-α expression brain mice. Although accumulated mercury concentration liver kidneys was greater than brain, to a extent brain. Thus, it is possible there may exist selective mechanism by which...
In 1952, the Japanese Society for Hygiene had once passed a resolution at its 22nd symposium on population control, recommending suppression of growth based idea cultivating healthier in area eugenics. Over half century has now since this recommendation; Japan is witnessing an aging (it estimated that over 65-year-olds made up 27.7% 2017) and decline birth rate (total fertility 1.43 births per woman unparalleled world; faced with "super-aging" society low rate. 2017, to encourage all...
Low-level lead exposure during childhood is associated with deficit in child IQ. However, the association between prenatal and IQ remains inconsistent. The objective of our study was to examine prenatal/postnatal at age 12. We obtained data pertaining cord-blood child-blood levels for 286 children from a prospective birth cohort (Tohoku Study Child Development). assessed using Wechsler Intelligence Scale Children-Fourth Edition. Simultaneously, Boston Naming Test (BNT) used assess children's...
Exposure to particulate matter (PM) is one of the important risk factors for morbidity and mortality. Although PM concentrations have been assessed using air quality monitoring stations or modelling, few studies measured indoor in large-scale birth cohorts. The Japan Environment Children's Study (JECS) outdoor approximately 5000 households when participating children were aged 1.5 3 years. was collected portable pumps 7 days (total 24 h), inside outside each home. Prediction models built...
Fish contain nutrients essential to the developing fetal brain, but they are contaminated with methylmercury. The Tohoku Study of Child Development, now underway in Sanriku coastal area Miyagi prefecture, Japan, follows mother-child pairs examine risks and benefits fish consumption during pregnancy, especially effects prenatal exposures methylmercury, selenium, docosahexaenoic acid (DHA) on child neurodevelopment. Children aged 18 months were administered Bayley Scales Infant Development...
The effects of prenatal exposures to polychlorinated biphenyls (PCBs), methylmercury, and lead on birth weight remain disputable. aim this study was investigate whether these chemicals affect Japanese newborns, with special emphasis determining differ between males females. subjects from Tohoku Study Child Development, which designed examine the developmental such hazardous chemicals, were 489 mother-newborn pairs complete data including smoking habit during pregnancy. mean all newborns 3083...
Poly- and perfluoroalkyl substances (PFAS) have been investigated in a number of cohort studies due to concern over their adverse health effects. The aim this study was develop reliable, high throughput cost-effective analytical method for broad range PFAS human serum. Protein precipitation, automatic solid phase extraction (SPE) pre-treatment column-switching LC-MS/MS were employed. optimised validated then used analyse the levels 28 339 maternal serum samples from Pilot Study Japan...
Exposure to several metallic elements has been suggested as a risk factor for gestational diabetes mellitus (GDM), but inconsistent findings have reported. This study aimed examine the association between maternal whole blood concentration of (Hg, Pb, Cd, Mn, and Se) GDM using dataset Japan Environment Children's Study (JECS), nationwide birth cohort study, which was designed adverse effects pre/post-natal exposure hazardous environment.The data 78,964 pregnant women who were participants...