Kouichi Ozaki
A5053237195- Cancer Immunotherapy and Biomarkers
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Bioinformatics and Genomic Networks
- Cell Adhesion Molecules Research
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Enzyme Production and Characterization
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Glycosylation and Glycoproteins Research
- interferon and immune responses
- Kawasaki Disease and Coronary Complications
- Pancreatic function and diabetes
- RNA Research and Splicing
National Center for Geriatrics and Gerontology
2017-2025
RIKEN Center for Integrative Medical Sciences
2016-2025
Hiroshima University
2024
Juntendo University
2023
Shimane University
2023
Juntendo University Hospital
2023
Tokyo University of Agriculture and Technology
2023
Toray Industries, Inc. (Japan)
2022
Utsunomiya University
2015-2016
Toyohashi University of Technology
2009-2014
The emerging field of synthetic genomics is expected to facilitate the generation microorganisms with potential achieve a sustainable society. One approach towards this goal reduction microbial genomes by rationally designed deletions create simplified cells predictable behavior that act as platform build in various genetic systems for specific purposes. We report novel Bacillus subtilis strain, MBG874, depleted 874 kb (20%) genomic sequence. When compared wild-type cells, regulatory network...
Background— Genetic predisposition to life-threatening cardiac arrhythmias such as congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden death in young adults children. Recently, mutations calmodulin ( CALM1 , CALM2 ) have been associated with severe forms LQTS CPVT, occurring very early life. Additional mutation-positive cases are needed discern genotype–phenotype correlations mutations. Methods Results— We...
Kawasaki disease (KD; OMIM 611775) is an acute vasculitis syndrome which predominantly affects small- and medium-sized arteries of infants children. Epidemiological data suggest that host genetics underlie the pathogenesis. Here we report multiple variants in caspase-3 gene (CASP3) are linkage disequilibrium confer susceptibility to KD both Japanese US subjects European ancestry. We found a G A substitution one commonly associated SNP located 5' untranslated region CASP3 (rs72689236; P = 4.2...
Background: Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these were mainly performed in Europeans. diverse populations have the potential to advance our understanding of CAD. Methods: We conducted 2 genome-wide for CAD Japanese population, which included 12 494 cases and 28 879 controls 2808 7261 controls, respectively. Then, we transethnic meta-analysis using results replication plus 1000 Genomes with UK Biobank. then explored...
Abstract Innovations in sequencing technology have led to the discovery of novel mutations that cause inherited diseases. However, many patients with suspected genetic diseases remain undiagnosed. Long-read technologies are expected significantly improve diagnostic rate by overcoming limitations short-read sequencing. In addition, Oxford Nanopore Technologies (ONT) offers adaptive sampling and computationally driven target enrichment technology. This enables more affordable intensive...