A5101462457- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Nuclear Receptors and Signaling
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Effects of Radiation Exposure
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Prostate Cancer Treatment and Research
- Drug Transport and Resistance Mechanisms
- HER2/EGFR in Cancer Research
Kanagawa Cancer Center
2021-2024
National Institutes for Quantum Science and Technology
2013-2024
Kanagawa Prefectural Hospital Organization
2021-2024
Yokohama City University
2019-2023
GTx (United States)
2021
National Institute for Japanese Language and Linguistics
2020
University of Fukui
2005-2011
Hokkaido University
2009
University of Tsukuba
2002-2008
National Institute of Health Sciences
1996
Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression associated with poor prognosis. Inhibitors of FASN, such as orlistat, reportedly show antitumor effects against cancers that over-express making FASN a promising therapeutic target. However, large variations levels individual tumors have been observed, methods to predict FASN-targeted therapy outcome before treatment are required avoid unnecessary treatment. In addition, how inhibition affects...
Radioactive copper (II) (diacetyl-bis N4-methylthiosemicarbazone) (Cu-ATSM) isotopes were originally developed for the imaging of hypoxia in tumors. Because decay a 64 Cu atom is emitting not only positrons but also Auger electrons, this radionuclide has great potential as theranostic agent. However, success Cu-ATSM internal radiation therapy would depend on contribution electrons to tumor cell killing. Therefore, we designed culture system define contributions death from support or refute...
Despite advances in breast cancer imaging, reliable detection of sentinel lymph node (SLN) metastasis remains challenging. This study aimed to determine the ability immuno-positron emission tomography (PET) using 64Cu-labeled cetuximab detect SLN a model epidermal growth factor receptor (EGFR)-positive cancer. The was established EGFR-strongly-expressing MDA-MB-468 cell line. In this xenograft model, [64Cu]Cu-PCTA-cetuximab administered intravenously (5.8 ± 0.9 MBq; n = 12) or both...
Previously, we conducted the phase I study of 64Cu-ATSM, which is Cu-diacetyl-bis (N4-methylthiosemicarbazone) radiolabeled with Cu-64, for patients brain tumors and determined maximum tolerated dose. We started a subsequent multicenter, randomized, open-label III to evaluate efficacy 64Cu-ATSM as an investigator-initiated registration-directed trial recurrent or residual malignant glioma (protocol No. NCCH2301, STEP-64). Patients will be randomized either control arm (64Cu-ATSM). A...
Primary central nervous system lymphoma (PCNSL) is an isolated type of the and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations MYD88 CD79B in immunocompetent PCNSL, whereas LMP1 activation commonly observed Epstein-Barr virus (EBV)-positive PCNSL. However, lack clinically representative preclinical models hampered our understanding pathogenic mechanisms by which genetic aberrations drive PCNSL disease phenotypes. Here,...
Pancreatic cancer (PC) has a very poor prognosis. Surgery is the primary treatment for patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal dissemination often occur even after extensive surgery. Adjuvant chemotherapy, typically gemcitabine, been used clinically but only modest survival benefit. To achieve better outcome, we investigated efficacy of <sup>64</sup>Cu-intraperitoneal radioimmunotherapy (ipRIT) <sup>64</sup>Cu-labeled antiepidermal growth...
Glioblastoma is the most aggressive malignant brain tumor in humans and difficult to cure using current treatment options. Hypoxic regions are frequently found glioblastoma, increased levels of hypoxia associated with poor clinical outcomes glioblastoma patients. Hypoxia plays important roles progression recurrence because drug delivery deficiencies induction hypoxia-inducible factor-1α cells, which lead prognosis. We focused on a promising hypoxia-targeted internal radiotherapy agent,...
Purpose 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) is a promising theranostic agent that targets hypoxic regions in tumors related to malignant characteristics. Its diagnostic usefulness has been recognized clinical studies. Internal radiotherapy (IRT) with 64Cu-ATSM reportedly effective preclinical studies; however, for applications, improvements reduce radiation exposure non-target organs, particularly the liver, are required. We developed strategy doses critical organs...
Photosynthetic pigments were analyzed by HPLC for 27 samples of the Cladophorales (Ulvophyceae, Chlorophyta). The carotenoid compositions examined algae classified into three types based on final compound biosynthesis α‐carotene branch: lutein type, characterized containing as a major and lacking loroxanthin siphonaxanthin; siphonaxanthin siphonaxanthin. We constructed molecular phylogenetic tree species in present study using 18S rRNA gene sequences mapped onto tree. analysis divided two...
// Yukie Yoshii 1 , Mitsuyoshi Yoshimoto 2 Hiroki Matsumoto 3 Hideaki Tashima Yuma Iwao Hiroyuki Takuwa Eiji Yoshida Hidekatsu Wakizaka Taiga Yamaya Ming-Rong Zhang Aya Sugyo Sayaka Hanadate Atsushi B. Tsuji and Tatsuya Higashi National Institute of Radiological Sciences, Institutes for Quantum Science Technology, Chiba, Japan Division Functional Imaging, Cancer Center Hospital East, Research Center, Nihon Medi-Physics Co., Ltd., Correspondence to: Yoshii, email: yoshii.yukie@qst.go.jp...
Abstract Pancreatic cancer (PC) has a poor prognosis owing to difficulties in the diagnosis of resectable PC at early stages. Several clinical studies have indicated that detection and surgery small (<1 cm) can significantly improve survival; however, imaging accurate resection remain challenging. Here, we report feasibility “immuno-OpenPET” as novel approach enabling not only but also image-guided surgery, using orthotopic xenograft mouse model. For immuno-OpenPET, utilized our original...
Carotenoid compositions were analyzed for ten strains of Nephroselmis (Prasinophyceae) containing four described and three undescribed species. Based on the distribution pattern siphonaxanthin series, five carotenoid types recognized in examined strains/species: type I ( N . astigmatica Inouye et Pienaar, N. pyriformis (N. Carter) Ettl, sp1. MBIC 11158) had C12:1 C14:1 esters as well 6′‐OH esters, II sp2. 11149) C8:1 ester, III sp3. NIES 486, NIES‐PS 535, 10871) 19‐methoxy IV spinosa Suda)...
Malignant mesothelioma is a highly aggressive form of cancer. Curative surgery the only effective therapy for mesothelioma, and therefore early diagnosis important. However, difficult using current diagnostic imaging techniques, new method urgently required. We evaluated affinity radiolabeled monoclonal antibodies to C-terminal fragment ERC/mesothelin this purpose.In-labeled or I-labeled IgG against ERC its Fab were in vitro by cell binding, competitive inhibition, cellular internalization...
The photosynthetic pigment composition of Mesostigma viride Lauterborn, a primitive green alga, was determined. This alga contained chl and b , lycopene, lutein, siphonaxanthin, γ‐carotene, β‐carotene, antheraxanthin, violaxanthin, neoxanthin, two novel carotenoid fatty acid esters, siphonaxanthin C12:0 ester C14:0 ester. esters were saturated, whereas all previously identified loroxanthin have been mono‐unsaturated ( trans ‐Δ2). Neoxanthin the all‐ form. is first such case detected in...
The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined efficacy combination tetrameric cyclic Arg-Gly-Asp (cRGD) peptide-based radiopharmaceutical, 64Cu-cyclam-RAFT-c(-RGDfK-)4 (64Cu-RaftRGD, an αVβ3 integrin [αVβ3] tracer), and 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM, supposed tracer hypoxic metabolism) in small animal tumor model.Mice...
Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ an anticancer radiopharmaceuticals targeting copper requirement of cells. However, intravenously injected ions primarily accumulate liver. Ligand complexation would be promising method increasing tumor delivery by reducing liver uptake. Herein, we used three tripodal amine ligands [tris(2-aminoethyl)amine (Tren), diethylenetriamine (Dien), tris(2-pyridylmethyl)amine (TPMA)] to...
2052 Background: Malignant brain tumors such as glioblastoma have poor prognosis. Current standard therapies surgery, radiotherapy, and chemotherapy were frequently insufficient. Hypoxic tissue microenvironments induced by rapid cellular growth within tumor lesions lead to treatment resistance. Methods: Eligible patients had a histological diagnosis of grade III/IV glioma, primary central nervous system malignant lymphoma (PCNSL), or II/III meningioma based on the most recent pathological...
Carotenoid composition and spectroscopic characteristics were analyzed for Pterosperma cristatum Schiller, one of the most primitive known members green algae. This alga contained a substantial amount carotenoid esters, siphonaxanthin C14:1 trans ‐Δ2 ester 6′‐OH ester, but lacked lutein. is first report esters from phototrophic organisms. In vivo absorption spectra excitation cells revealed that these carotenoids absorbed blue‐green light could transfer energy to chl a. These concluded...
Actinium-225 (225Ac) is a promising radionuclide used in targeted alpha therapy (TAT). Although 225Ac labeling of bifunctional chelating ligands effective, previous vivo studies reported that free can be released from the drugs and such predominantly accumulated liver could cause unexpected toxicity. To accelerate clinical development TAT with variety drugs, preparing methods to deal any toxicity would valuable. The aim this study was evaluate feasibility various chelators for reducing...
Colon cancer is one of the leading causes death worldwide. Adjuvant chemotherapy following primary surgical treatment suggested to be beneficial in eradicating invisible disseminated small tumors colon cancer; however, an effective drug remains developed. Recently, we reported a novel screening system using nanoimprinting 3-dimensional (3D) culture that creates multicellular spheroids, which simulate vivo conditions and, thereby, predict drugs vivo. This study aimed perform selection our...